| Research Topics: |
| INDEX |
| AI-chat 1 |
| MCS 1 |
| PRIME 29 |
| aging 11 |
| arts 1 |
| brain 10 |
| brainwave 2 |
| cancer 6 |
| climate 1 |
| cognition 3 |
| covid-19 1 |
| crime 1 |
| culture 1 |
| dental 1 |
| diabetes 4 |
| disease 1 |
| economy 2 |
| exercise 1 |
| eyes 2 |
| gender 1 |
| genetics 2 |
| gut 2 |
| heart 4 |
| immune 6 |
| lungs 1 |
| metabolism 1 |
| microbiome 2 |
| nutrition 1 |
| obesity 1 |
| politics 8 |
| pollution 1 |
| practice 1 |
| privacy 1 |
| psychology 5 |
| reproduction 2 |
| sleep 1 |
| soc-media |
| unk |
| vaccine 1 |
| virus 2 |
| war-confl |
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Scanned: 2706 Evaluated: 166 Selected: 52 |
| PRIME AGING BRAIN IMMUNE | |||||||||||||||||||||||||||||||||||||||||
Aaa06-005 | The Amazing Benefits of Spermidine | ||||||||||||||||||||||||||||||||||||||||
| Quote: | In recent years, spermidine has emerged as a compound of interest in longevity and nutrition science, largely due to its role in autophagy, the bodys cellular cleanup system. However, spermidines importance extends well beyond general anti-aging mechanisms. In the brain, spermidine belongs to a class of molecules called polyamines, which play a critical role in regulating how brain cells communicate, adapt, and remain resilient over time. What are polyamines? Understanding spermidines neurological relevance begins with understanding what polyamines are and how they function in the nervous system. | ||||||||||||||||||||||||||||||||||||||||
| Article: | https://richardgoldberg.substack.com/p/the-amazing-benefits-of-spermidine | ||||||||||||||||||||||||||||||||||||||||
| Search Similar: | Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho | ||||||||||||||||||||||||||||||||||||||||
| Search Authors: | Richard Goldberg, Felton Nutrition, | ||||||||||||||||||||||||||||||||||||||||
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| AGING IMMUNE | |||||||||||||||||||||||||||||||||||||||||
Mep06-014 | Circulating Cell Type Senescence Signatures Reveal High-Resolution Health Status and Trajectories in Human Longitudinal Studies | ||||||||||||||||||||||||||||||||||||||||
| Quote: | Notably, pooled senescence proteins outperformed non-senescence proteins in predicting many clinical parameters such as age and hypertension, and in many instances cell type senescence signatures mapped most strongly to their corresponding health domain. Importantly, the immune cell senescence signature is associated with future onset of several diseases such as diabetes. This study demonstrates that circulating cell type-specific biomarkers of senescence can reveal higher resolution health status than previously attained. | ||||||||||||||||||||||||||||||||||||||||
| Abstract: | https://www.medrxiv.org/content/10.64898/2026.02.06.26345739v1 | ||||||||||||||||||||||||||||||||||||||||
| Full Text: | https://www.medrxiv.org/content/10.64898/2026.02.06.26345739v1.full-text | ||||||||||||||||||||||||||||||||||||||||
| Search Similar: | Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho | ||||||||||||||||||||||||||||||||||||||||
| Search Authors: | Bradley Olinger Carlos Anerillas Allison B. Herman Dimitrios Tsitsipatis Reema Banarjee Toshiko Tanaka Julian Candia Manolis Maragkakis Stefania Bandinelli Keenan A. Walker Eleanor M. Simonsick Yue A Qi Luigi Ferrucci Myriam Gorospe Nathan Basisty, | ||||||||||||||||||||||||||||||||||||||||
| IMMUNE LUNGS VACCINE VIRUS | |||||||||||||||||||||||||||||||||||||||||
Min06-010 | The interaction between influenza vaccination and nasal pneumococcal colonization alters airway T cell responses and alveolar macrophage activation | ||||||||||||||||||||||||||||||||||||||||
| Quote: | Conclusions Our findings define how influenza vaccination and pneumococcal colonization converge in the human lung to reprogram AM-T cell crosstalk, enhancing local immune responses and protective immunity. By uncovering conserved macrophage modules and mechanisms that shape mucosal defense, this study provides a framework for designing next-generation respiratory vaccines and strategies to mitigate post-viral bacterial pneumonia. | ||||||||||||||||||||||||||||||||||||||||
| Abstract: | https://www.medrxiv.org/content/10.64898/2026.02.05.26345662v1 | ||||||||||||||||||||||||||||||||||||||||
| Full Text: | https://www.medrxiv.org/content/10.64898/2026.02.05.26345662v1.full-text | ||||||||||||||||||||||||||||||||||||||||
| Search Similar: | Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho | ||||||||||||||||||||||||||||||||||||||||
| Search Authors: | Yuzhou Evelyn Tong Sergio Triana Daniela D. Russo Jesus Reine Jamie Rylance Simon P. Jochems Oluwasefunmi Akeju Pardis C. Sabeti Alex K. Shalek Daniela M. Ferreira Elena Mitsi, | ||||||||||||||||||||||||||||||||||||||||
| IMMUNE PSYCHOLOGY | |||||||||||||||||||||||||||||||||||||||||
Mpy06-004 | Genetic evidence for repurposing immunomodulatory drugs for major depressive disorder | ||||||||||||||||||||||||||||||||||||||||
| Quote: | Conclusion We provide genetic evidence supporting the repurposing of immunomodulatory drugs for MDD, including compounds acting on novel therapeutic targets. Effects differ across depressive symptoms, suggesting that symptoms respond to different drug mechanisms. These findings highlight the importance of considering individual symptoms, rather than MDD as a unitary condition, when developing treatments with a broad spectrum of action or targeting specific symptom profiles. | ||||||||||||||||||||||||||||||||||||||||
| Abstract: | https://www.medrxiv.org/content/10.64898/2026.02.07.26345798v1 | ||||||||||||||||||||||||||||||||||||||||
| Full Text: | https://www.medrxiv.org/content/10.64898/2026.02.07.26345798v1.full-text | ||||||||||||||||||||||||||||||||||||||||
| Search Similar: | Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho | ||||||||||||||||||||||||||||||||||||||||
| Search Authors: | Jehanita Jesuthasan Abigail R ter Kuile Jonathan Roiser Livia A Carvalho Alexandra Pitman Sandesh Chopade Chris Finan Amand Floriaan Schmidt Jean-Baptiste Pingault, | ||||||||||||||||||||||||||||||||||||||||
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| MCS PRIME IMMUNE | |||||||||||||||||||||||||||||||||||||||||
Mrh06-002 | NHAPL analysis of glycoRNA reveals sialic acid-containing glycosylated mRNA 3UTRs and enables sensitive SLE diagnostics | ||||||||||||||||||||||||||||||||||||||||
| Quote: | we identify glycoRNA signatures highly specific to systemic lupus erythematosus SLE. In particular, glycoY5 and glycoU1 achieve near-complete discrimination between patients and healthy controls area under the curve AUC 1.00 and 0.9977, whereas conventional total RNA analysis fails to capture these differences, highlighting RNA glycosylation modification as a distinct regulatory layer. Its simplicity and flexibility make it well suited for clinical glycoRNA profiling and biomarker discovery. | ||||||||||||||||||||||||||||||||||||||||
| Abstract: | https://www.medrxiv.org/content/10.64898/2026.02.05.26345357v1 | ||||||||||||||||||||||||||||||||||||||||
| Full Text: | https://www.medrxiv.org/content/10.64898/2026.02.05.26345357v1.full-text | ||||||||||||||||||||||||||||||||||||||||
| Search Similar: | Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho | ||||||||||||||||||||||||||||||||||||||||
| Search Authors: | Jie Gui Meng Zhang Ziwei Kan Xiaojuan He Meipei Gao Jian Han Qiongfang Wang Shengyao Zhang Junyi Hu Wenyi Qin Zi Bi Boyue Huang Zhongjun Wu Jianhua Ran, | ||||||||||||||||||||||||||||||||||||||||
| PRIME IMMUNE | |||||||||||||||||||||||||||||||||||||||||
Mrh06-004 | Pan-disease blood protein profiles of rheumatic autoimmune diseases | ||||||||||||||||||||||||||||||||||||||||
| Quote: | Systemic autoimmune rheumatic diseases SARDs are a heterogeneous group of autoimmune conditions characterized by immune system dysregulation leading to chronic inflammation and tissue damage. The overlapping clinical manifestations make differential diagnosis challenging, ... This explorative cross-sectional study demonstrates the importance of a pan-disease approach to biomarker identification within and between the five SARDs. NPX boxplots from this study are available open-access through the Human Protein Atlas, facilitating further plasma-proteome research on autoimmune diseases. | ||||||||||||||||||||||||||||||||||||||||
| Abstract: | https://www.medrxiv.org/content/10.64898/2026.02.05.26345462v1 | ||||||||||||||||||||||||||||||||||||||||
| Full Text: | https://www.medrxiv.org/content/10.64898/2026.02.05.26345462v1.full-text | ||||||||||||||||||||||||||||||||||||||||
| Search Similar: | Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho | ||||||||||||||||||||||||||||||||||||||||
| Search Authors: | Josefin Kenrick Charlotta Preger Mara Bueno lvez Alejandra Ulloa Gran Bergstrm Antonella Notarnicola Begum Horuluoglu Anna Smed-Srensen Anna Frnert Anna Norrby-Teglund Iva Gunnarsson Marie Wahren-Herlenius Marie Holmqvist Leonid Padyukov Karine Chemin Lina Marcela Diaz-Gallo Ingrid E. Lundberg Elisabet Svenungsson Vivianne Malmstrm Lars Klareskog Sofia Bergstrm Mathias Uhln Peter Nilsson Fredrik Edfors Elisa Pin, | ||||||||||||||||||||||||||||||||||||||||
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02/13/2026-07:20:23 PM
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