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Mrh06-002

NHAPL analysis of glycoRNA reveals sialic acid-containing glycosylated mRNA 3UTRs and enables sensitive SLE diagnostics

Quote:we identify glycoRNA signatures highly specific to systemic lupus erythematosus SLE. In particular, glycoY5 and glycoU1 achieve near-complete discrimination between patients and healthy controls area under the curve AUC 1.00 and 0.9977, whereas conventional total RNA analysis fails to capture these differences, highlighting RNA glycosylation modification as a distinct regulatory layer. Its simplicity and flexibility make it well suited for clinical glycoRNA profiling and biomarker discovery.
Abstract: https://www.medrxiv.org/content/10.64898/2026.02.05.26345357v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.02.05.26345357v1.full-text
Search Similar: Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho 
Search Authors: Jie Gui Meng Zhang Ziwei Kan Xiaojuan He Meipei Gao Jian Han Qiongfang Wang Shengyao Zhang Junyi Hu Wenyi Qin Zi Bi Boyue Huang Zhongjun Wu Jianhua Ran, 

  Updated weekly. 02/20/2026-11:39:18 PM
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