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GENETICS
PSYCHOLOGY
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Mge06-002 | Genomic insights into substance use and disinhibitory disorders |
| Quote: | Our findings partially support a distress-fear genetic distinction, but show stronger evidence for an overarching genetic liability to internalising psychopathology driving comorbidity across anxiety disorders and depression.
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| Abstract:
| https://www.medrxiv.org/content/10.64898/2026.02.09.26344198v1 |
| Full Text:
| https://www.medrxiv.org/content/10.64898/2026.02.09.26344198v1.full-text |
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| Search Authors: |
Camille M. Williams Holly E. Poore Diego Londono-Correa Yuchen Ning Natasia S. Courchesne-Krak Maia Choi Justin D. Tubbs Matthew Rosenblatt Peter T. Tanksley Fazil Aliev Nathaniel Y. Bell Joseph D. Deak Jean Gonzalez Mariela Jennings Emma C. Johnson Tanya N. Phung Marijn Schipper Ronald de Vlaming Kai Yuan Hang Zhou Emily Balcke Sarah J. Brislin span classnlm-collab data-hwp-idcollab-1COGA Collaborators Javier de la Fuente Michael J. Gandal Tian Ge Joel Gelernter Danielle Posthuma Jordan W. Smoller Elliot M. Tucker-Drob Irwin D. Waldman Abraham A. Palmer Peter B. Barr Sandra Sanchez-Roige Richard Karlsson Linnr Danielle M. Dick K. Paige Harden Travis T. Mallard,
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CANCER
GENETICS
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Mge06-004 | Genome-wide association study meta-analysis identifies susceptibility loci informing Ewing sarcoma etiology and potential mechanisms of risk |
| Quote: | Integrative analyses of the EwS loci revealed enrichment of expanded GGAA microsatellites, with evidence for binding of the EWSR1::FLI1 chimeric oncogenic activator. EWSR1::ETS knockdown in EwS cell lines resulted in dysregulated genes at susceptibility loci related to skeletal/muscle development, RNA binding/processing, and chromatin regulation.
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| Abstract:
| https://www.medrxiv.org/content/10.64898/2026.02.06.26345779v1 |
| Full Text:
| https://www.medrxiv.org/content/10.64898/2026.02.06.26345779v1.full-text |
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Aubrey K. Hubbard Hlne Neyret-Kahn Martina Mller-Nurasiyd Dominik Lw Konstantin Strauch Olivia W. Lee Andrew R. Raduski Tianzhong Yang Weiyin Zhou Elliot W. Stratton Orson Jay Sandrine Grossette Andrew J. Song Diptavo Dutta Amy A. Hutchinson Belynda D. Hicks Michelle Manning Jia Liu Carrie Boyce Wolfgang Hartmann Uta Dirksen Andreas E. Kulozik Markus Metzler Manuela Krumbholz Alexander Teumer Henry Vlzke Uwe Vlker Joshua D. Schiffman Javed Khan Melissa M. Hudson Kirsten K. Ness Zhaoming Wang Katherine A. Janeway Philip J. Lupo Logan G. Spector Wen-Yi Huang Steven C. Moore Stephen J. Chanock Thomas G.P. Grnewald Olivier Delattre Mitchell J. Machiela,
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GENETICS
PSYCHOLOGY
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Mge06-006 | Genome-wide genetic overlap between fear-based disorders and generalised anxiety disorder |
| Quote: | Most complex traits had statistically similar genetic correlations with fear and GAD, including depression. Exceptions included general cognitive ability, educational attainment, and coronary artery disease, showing statistically stronger genetic correlations with fear than GAD, while bipolar disorder type I, anorexia nervosa, and neuroticism displayed the opposite pattern.
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| Abstract:
| https://www.medrxiv.org/content/10.64898/2026.02.06.26345742v1 |
| Full Text:
| https://www.medrxiv.org/content/10.64898/2026.02.06.26345742v1.full-text |
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Abigail R. ter Kuile Brittany L. Mitchell Sang Hyuck Lee Genevive Morneau-Vaillancourt Megan Skelton Jonathan R. I. Coleman Helena L. Davies Jessica Mundy Alicia J. Peel Christopher Hbel Molly R. Davies Anna E. Frtjes Zain Ahmad Yuhao Lin Brett N. Adey Thomas McGregor Alish Palmos Johan Zvrskovec Matthew Hotopf Gursharan Kalsi Ian R. Jones Daniel J. Smith David Veale James T. R. Walters Chrie Armour Colette R. Hirsch Andrew M. McIntosh Naomi R. Wray Sarah E. Medland Enda M. Byrne Nicholas G. Martin Nathalie Kingston John R. Bradley span classnlm-collab data-hwp-idcollab-1NIHR BioResource Gerome Breen Thalia C. Eley,
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GENETICS
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Mge07-034 | Distinguishing causal from tagging enhancers using single-cell multiome data |
| Abstract:
| https://www.medrxiv.org/content/10.64898/2026.02.15.26346353v1 |
| Full Text:
| https://www.medrxiv.org/content/10.64898/2026.02.15.26346353v1.full-text |
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Elizabeth Dorans Alkes L Price,
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BRAIN
GENETICS
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Mpy07-022 | Shared and distinct phenotypic profiles among neurodevelopmental disorder genes |
| Quote: | Gene Ontology enrichment analyses revealed distinct biological processes in each cluster, suggesting that coherent molecular mechanisms underlie the diYering NDD diagnostic profiles. Together these findings demonstrate that NDD genes fall into coherent clusters that consistently map onto characteristic phenotype profiles, providing a framework to inform future therapeutic strategies and support early prognostication for individuals with pathogenic variants in NDD genes.
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| Abstract:
| https://www.medrxiv.org/content/10.64898/2026.02.15.26346328v1 |
| Full Text:
| https://www.medrxiv.org/content/10.64898/2026.02.15.26346328v1.full-text |
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Hermela Shimelis Matthew T. Oetjens Bobbi McGivern Zhancheng Zhang Janelle E. Stanton Ian McSalley Shiva Ganesan Brenda M. Finucane Ingo Helbig Christa L. Martin Scott M. Myers David H. Ledbetter,
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