| Research Topics: |
| INDEX |
| AI-chat 2 |
| MCS 1 |
| PRIME 26 |
| aging 9 |
| brain 11 |
| brainwave 2 |
| cancer 4 |
| climate 4 |
| cognition 7 |
| covid-19 2 |
| diabetes 2 |
| diagnostics 2 |
| economy 2 |
| eyes 2 |
| genetics 5 |
| heart 2 |
| immune 6 |
| language 1 |
| law 1 |
| lungs 1 |
| metabolism 1 |
| microbiome 1 |
| misc |
| nutrition 4 |
| politics 3 |
| pollution 3 |
| psychology 6 |
| sleep 4 |
| vaccine 1 |
| virus 2 |
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Scanned: 2653 Evaluated: 237 Selected: 57 |
| GENETICS PSYCHOLOGY | |||||||||||||||||||
Mge06-002 | Genomic insights into substance use and disinhibitory disorders | ||||||||||||||||||
| Quote: | Our findings partially support a distress-fear genetic distinction, but show stronger evidence for an overarching genetic liability to internalising psychopathology driving comorbidity across anxiety disorders and depression. | ||||||||||||||||||
| Abstract: | https://www.medrxiv.org/content/10.64898/2026.02.09.26344198v1 | ||||||||||||||||||
| Full Text: | https://www.medrxiv.org/content/10.64898/2026.02.09.26344198v1.full-text | ||||||||||||||||||
| Search Similar: | Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho | ||||||||||||||||||
| Search Authors: | Camille M. Williams Holly E. Poore Diego Londono-Correa Yuchen Ning Natasia S. Courchesne-Krak Maia Choi Justin D. Tubbs Matthew Rosenblatt Peter T. Tanksley Fazil Aliev Nathaniel Y. Bell Joseph D. Deak Jean Gonzalez Mariela Jennings Emma C. Johnson Tanya N. Phung Marijn Schipper Ronald de Vlaming Kai Yuan Hang Zhou Emily Balcke Sarah J. Brislin span classnlm-collab data-hwp-idcollab-1COGA Collaborators Javier de la Fuente Michael J. Gandal Tian Ge Joel Gelernter Danielle Posthuma Jordan W. Smoller Elliot M. Tucker-Drob Irwin D. Waldman Abraham A. Palmer Peter B. Barr Sandra Sanchez-Roige Richard Karlsson Linnr Danielle M. Dick K. Paige Harden Travis T. Mallard, | ||||||||||||||||||
| GENETICS PSYCHOLOGY | |||||||||||||||||||
Mge06-006 | Genome-wide genetic overlap between fear-based disorders and generalised anxiety disorder | ||||||||||||||||||
| Quote: | Most complex traits had statistically similar genetic correlations with fear and GAD, including depression. Exceptions included general cognitive ability, educational attainment, and coronary artery disease, showing statistically stronger genetic correlations with fear than GAD, while bipolar disorder type I, anorexia nervosa, and neuroticism displayed the opposite pattern. | ||||||||||||||||||
| Abstract: | https://www.medrxiv.org/content/10.64898/2026.02.06.26345742v1 | ||||||||||||||||||
| Full Text: | https://www.medrxiv.org/content/10.64898/2026.02.06.26345742v1.full-text | ||||||||||||||||||
| Search Similar: | Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho | ||||||||||||||||||
| Search Authors: | Abigail R. ter Kuile Brittany L. Mitchell Sang Hyuck Lee Genevive Morneau-Vaillancourt Megan Skelton Jonathan R. I. Coleman Helena L. Davies Jessica Mundy Alicia J. Peel Christopher Hbel Molly R. Davies Anna E. Frtjes Zain Ahmad Yuhao Lin Brett N. Adey Thomas McGregor Alish Palmos Johan Zvrskovec Matthew Hotopf Gursharan Kalsi Ian R. Jones Daniel J. Smith David Veale James T. R. Walters Chrie Armour Colette R. Hirsch Andrew M. McIntosh Naomi R. Wray Sarah E. Medland Enda M. Byrne Nicholas G. Martin Nathalie Kingston John R. Bradley span classnlm-collab data-hwp-idcollab-1NIHR BioResource Gerome Breen Thalia C. Eley, | ||||||||||||||||||
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| IMMUNE PSYCHOLOGY | |||||||||||||||||||
Mpy06-004 | Genetic evidence for repurposing immunomodulatory drugs for major depressive disorder | ||||||||||||||||||
| Quote: | Conclusion We provide genetic evidence supporting the repurposing of immunomodulatory drugs for MDD, including compounds acting on novel therapeutic targets. Effects differ across depressive symptoms, suggesting that symptoms respond to different drug mechanisms. These findings highlight the importance of considering individual symptoms, rather than MDD as a unitary condition, when developing treatments with a broad spectrum of action or targeting specific symptom profiles. | ||||||||||||||||||
| Abstract: | https://www.medrxiv.org/content/10.64898/2026.02.07.26345798v1 | ||||||||||||||||||
| Full Text: | https://www.medrxiv.org/content/10.64898/2026.02.07.26345798v1.full-text | ||||||||||||||||||
| Search Similar: | Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho | ||||||||||||||||||
| Search Authors: | Jehanita Jesuthasan Abigail R ter Kuile Jonathan Roiser Livia A Carvalho Alexandra Pitman Sandesh Chopade Chris Finan Amand Floriaan Schmidt Jean-Baptiste Pingault, | ||||||||||||||||||
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| PRIME AGING BRAIN COGNITION PSYCHOLOGY | |||||||||||||||||||
Mpy06-020 | Functional MRS uncovers age-related alterations in cerebral lactate dynamics during emotional-cognitive engagement, revealing metabolic vulnerability in the dACC | ||||||||||||||||||
| Quote: | Introduction Lactate plays dual roles in neuronal energy metabolism and signalling. The dorsal anterior cingulate cortex dACC, a region with high baseline glycolytic activity implicated in psychiatric disorders, may exhibit dynamic lactate responses to graded cognitive-emotional demands. Because mitochondrial function declines with age, aging may model whether fMRS-derived lactate dynamics can detect latent neurometabolic vulnerabilities. ... establishes a metabolic stress-testing paradigm for detecting latent neuroenergetic vulnerabilities, supporting fMRS utility for probing mitochondrial function in health and psychiatric disorders. | ||||||||||||||||||
| Abstract: | https://www.medrxiv.org/content/10.64898/2026.02.05.26345665v1 | ||||||||||||||||||
| Full Text: | https://www.medrxiv.org/content/10.64898/2026.02.05.26345665v1.full-text | ||||||||||||||||||
| Search Similar: | Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho | ||||||||||||||||||
| Search Authors: | Edward Caddye Joel Patchitt Anouk Schrantee William T Clarke Itamar Ronen Alessandro Colasanti, | ||||||||||||||||||
| AI-CHAT PRIME PSYCHOLOGY | |||||||||||||||||||
Mpy07-026 | Reproducible symptom subtypes of depression identified using unsupervised machine learning | ||||||||||||||||||
| Quote: | Clusters aligned with the existing clinical subtypes, atypical and melancholic depression, alongside other potentially novel clusters reflecting a range of different symptom profiles. Atypical clusters hypersomnia with weight gain appeared in both Q1 and Q2 and were associated with younger age and higher body mass index. Distinct clusters combining insomnia, weight gain, and having thoughts of death were associated with asthma, suggesting potential inflammatory dysregulation. Further clusters were characterised by psychomotor changes and showed strong associations with Parkinsons disease, both before and after the mental health questionnaire was conducted. | ||||||||||||||||||
| Abstract: | https://www.medrxiv.org/content/10.64898/2026.02.13.26346271v1 | ||||||||||||||||||
| Full Text: | https://www.medrxiv.org/content/10.64898/2026.02.13.26346271v1.full-text | ||||||||||||||||||
| Search Similar: | Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho | ||||||||||||||||||
| Search Authors: | David M. Howard Francisco Diego Rabelo-da-Ponte Maria Viejo-Romero Evangelos Vassos Cathryn M. Lewis, | ||||||||||||||||||
| PSYCHOLOGY | |||||||||||||||||||
Mpy07-028 | Biological embedding of the pyscho-social environment; an Epigenetic Analysis of Adversity from Early-life to Adulthood | ||||||||||||||||||
| Quote: | Pathway enrichment analysis of the combined dataset showed potential associations with oxytocin signalling, regulation of nervous system development, and calcium signalling in relation to the later-life phenotype of the adversity exposed individuals. | ||||||||||||||||||
| Abstract: | https://www.medrxiv.org/content/10.64898/2026.02.13.26345039v1 | ||||||||||||||||||
| Full Text: | https://www.medrxiv.org/content/10.64898/2026.02.13.26345039v1.full-text | ||||||||||||||||||
| Search Similar: | Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho | ||||||||||||||||||
| Search Authors: | Megan Buchanan Jeanne Le Clach Sophie B. Mriaux Jonathan D. Turner Archibold Mposhi, | ||||||||||||||||||
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02/20/2026-11:39:18 PM
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