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Min06-010

The interaction between influenza vaccination and nasal pneumococcal colonization alters airway T cell responses and alveolar macrophage activation

Quote:Conclusions Our findings define how influenza vaccination and pneumococcal colonization converge in the human lung to reprogram AM-T cell crosstalk, enhancing local immune responses and protective immunity. By uncovering conserved macrophage modules and mechanisms that shape mucosal defense, this study provides a framework for designing next-generation respiratory vaccines and strategies to mitigate post-viral bacterial pneumonia.
Abstract: https://www.medrxiv.org/content/10.64898/2026.02.05.26345662v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.02.05.26345662v1.full-text
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Search Authors: Yuzhou Evelyn Tong Sergio Triana Daniela D. Russo Jesus Reine Jamie Rylance Simon P. Jochems Oluwasefunmi Akeju Pardis C. Sabeti Alex K. Shalek Daniela M. Ferreira Elena Mitsi, 

  Updated weekly. 02/20/2026-11:39:18 PM
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