AGING BRAIN GENETICS LUNGS
Mge09-006	Genome-wide cross-trait analysis of vascular dementia and Alzheimers disease highlights novel loci and lung-brain axis
	Quote:	A multi-omics integrative analysis identified 619 genes. 241 genes were significantly differentially expressed in VD cells and 21 exhibited strong evidence of interaction with FDA-approved drugs. Collectively, our findings provide valuable insights into the potential underlying mechanisms of VD.
	Abstract:	https://www.medrxiv.org/content/10.64898/2026.02.27.26345967v1
	Full Text:	https://www.medrxiv.org/content/10.64898/2026.02.27.26345967v1.full-text
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	Search Authors:	Guiyou Liu span classnlm-suffixSr. Shan Gao Shiyang Wu Fengzhen Liu Ping Zhu Yijie He Shuyuan Hu Ruibai Wang Jin Yang Lu Zhao Xuman Liu Zhifa Han Tao Wang Yan Zhang Kun Wang Yan Chen Keshen Li,
AGING BRAIN COGNITION
Mgr09-024	Linking Modifiable Risk Factors to Vascular and Neurodegenerative Brain Changes
	Quote:	RESULTS Higher burden was associated with poorer global cognition, greater clinical severity, worse memory and fluency, and higher odds of WMHs, infarcts, and hippocampal atrophy. Structural equation models identified hippocampal atrophy as the primary mediator, with smaller effects for WMHs and infarcts.
	Abstract:	https://www.medrxiv.org/content/10.64898/2026.02.28.26347178v1
	Full Text:	https://www.medrxiv.org/content/10.64898/2026.02.28.26347178v1.full-text
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	Search Authors:	Tamara Khudair Shima Raeesi Farooq Kamal Mahsa Dadar Cassandra morrison,
BRAIN SLEEP
Mgr09-026	Dissociating the Nocturnal Physiological Drivers of Agitation Occurrence and Severity in Dementia: An Explanatory Study Using Contactless Sleep Sensing
	Quote:	RESULTS Lower nocturnal respiratory rate and greater activity instability independently predicted higher odds of next-day agitation occurrence. Associations were stronger for motor than verbal agitation. Respiration-related predictors were validated externally. Conversely, no nocturnal features significantly predicted agitation severity. DISCUSSION Passive sleep monitoring identified reproducible, physiologically interpretable markers of next-day agitation occurrence, supporting the potential of under-mattress sensing for short-term risk stratification and more proactive dementia care.
	Abstract:	https://www.medrxiv.org/content/10.64898/2026.02.27.26346707v1
	Full Text:	https://www.medrxiv.org/content/10.64898/2026.02.27.26346707v1.full-text
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	Search Authors:	Zhen Liu Marta Bono Ajda Flisar Robbe Decloedt Maarten De Vos Maarten Van Den Bossche,
BRAIN COGNITION PHYSICAL
Mne09-030	Cognition, Lifestyles, and Environments: Quantifying the Roles of Body Physiology and the Brain
	Quote:	A model integrating all lifestyle and environment domains explained 23 of the variance in cognition at an out-of-sample r0.48, comparable to models based on body and brain measures. Physical activity, together with diet, alcohol consumption, sun exposure, and local environmental characteristics, emerged as the strongest predictors of cognitive functioning.
	Abstract:	https://www.medrxiv.org/content/10.64898/2026.02.26.26347222v1
	Full Text:	https://www.medrxiv.org/content/10.64898/2026.02.26.26347222v1.full-text
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	Search Authors:	Irina Buianova Narun Pat,
BRAIN IMMUNE
Mpt09-024	Robust Immunohistochemical Detection of -Synuclein, Tau, and -Amyloid in Human Brain Tissue Archived for up to 78 Years
	Quote:	Conclusion Human brain tissue preserved as paraffin-embedded blocks or stored in fixative for up to 78 years remains suitable for immunohistochemical analyses. Adequate-to-good detection of aggregated of -synuclein, hyperphosphorylated tau and amyloid- is achievable, indicating preserved pathological hallmarks of Lewy Body Disease and Alzheimers Disease in archival tissue.
	Abstract:	https://www.medrxiv.org/content/10.64898/2026.02.26.26345861v1
	Full Text:	https://www.medrxiv.org/content/10.64898/2026.02.26.26345861v1.full-text
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	Search Authors:	Mie Kristine Just Kristina Bang Christensen Martin Wirenfeldt Torben Steiniche Laura Parkkinen Liisa Myllykangas Per Borghammer,
BRAIN EXERCISE
Mre09-028	Aerobic exercise improves executive function after traumatic brain injury via changes to the functional connectivity of the anterior cingulate cortex
	Abstract:	https://www.medrxiv.org/content/10.64898/2026.02.27.26347275v1
	Full Text:	https://www.medrxiv.org/content/10.64898/2026.02.27.26347275v1.full-text
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	Search Authors:	Emma M. Tinney Mark C. Nwakamma Goretti Espaa-Irla Madeleine L. Perko Lauren Kong Colette Chen Jeremy Hwang Amanda OBrien Ryan Luke Sodemann Jacqueline Caefer Julia Manczurowsky Charles H. Hillman Alexandra Stillman Timothy P. Morris,

Javilk's Research Links for Week 09
Updated 03/07/2026-12:02:44 AM
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Mge09-006

Genome-wide cross-trait analysis of vascular dementia and Alzheimers disease highlights novel loci and lung-brain axis

Mgr09-024

Linking Modifiable Risk Factors to Vascular and Neurodegenerative Brain Changes

Mgr09-026

Dissociating the Nocturnal Physiological Drivers of Agitation Occurrence and Severity in Dementia: An Explanatory Study Using Contactless Sleep Sensing

Mne09-030

Cognition, Lifestyles, and Environments: Quantifying the Roles of Body Physiology and the Brain

Mpt09-024

Robust Immunohistochemical Detection of -Synuclein, Tau, and -Amyloid in Human Brain Tissue Archived for up to 78 Years

Mre09-028

Aerobic exercise improves executive function after traumatic brain injury via changes to the functional connectivity of the anterior cingulate cortex