Research
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Scanned: 2656
Evaluated: 168
Selected: 44
 
    AGING    BRAIN    GENETICS    LUNGS   

Mge09-006

Genome-wide cross-trait analysis of vascular dementia and Alzheimers disease highlights novel loci and lung-brain axis

Quote:A multi-omics integrative analysis identified 619 genes. 241 genes were significantly differentially expressed in VD cells and 21 exhibited strong evidence of interaction with FDA-approved drugs. Collectively, our findings provide valuable insights into the potential underlying mechanisms of VD.
Abstract: https://www.medrxiv.org/content/10.64898/2026.02.27.26345967v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.02.27.26345967v1.full-text
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Search Authors: Guiyou Liu span classnlm-suffixSr. Shan Gao Shiyang Wu Fengzhen Liu Ping Zhu Yijie He Shuyuan Hu Ruibai Wang Jin Yang Lu Zhao Xuman Liu Zhifa Han Tao Wang Yan Zhang Kun Wang Yan Chen Keshen Li, 
    GENETICS   

Mge09-012

De novo variants in LDB1 are linked to distinct neurodevelopmental phenotypes determined by variant location and differing pathomechanisms

Abstract: https://www.medrxiv.org/content/10.64898/2026.02.26.26347174v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.02.26.26347174v1.full-text
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Search Authors: Rebecca Fluri Mireia Coll-Tan Theresa Brunet Benjamin Cogne Solene Conrad Mathilde Nizon Francesco Nicita Lorena Travaglini Antonio Novelli Margie Glissmeyer Amanda Peterson Jillian G. Buchan Dan Serber Kolja Meier Jutta Grtner Susann Diegmann Veronique Pingault Tania Attie-Bitach Thomas Courtin Michael C. Schneider Wing Hung Inderneel Sahai Lauren OGrady Katharina Steindl Sarju G. Mehta Christel Depienne Delphine Heron Boris Keren Solveig Heide Shane McKee Franco Laccone Lisa M. Dyer Catherine Melver Connie Motter Wendy D. Jones Zoey Trueblood Wilson Divya Vats Kristina Hu Christiane Zweier Heinrich Sticht Anne Gregor, 
    GENETICS    HEART    IMMUNE   

Mhe09-022

Genetic insights into immunothrombosis: from shared loci to repurposed drugs for autoimmune and thrombotic diseases

Quote:Colocalization confirmed that shared genetic susceptibility is primarily driven by expression in arterial tissues aorta and coronary rather than exclusively in immune cells. Furthermore, the lead SNP rs4129267 was identified as a potential predictor for VTE in rheumatoid arthritis patients, and drug prioritization nominated TNF inhibitors as promising candidates for mitigating thrombotic burden. Conclusion This study establishes the first genomic atlas of the autoimmune-thrombotic axis, demonstrating that vasculature-specific gene regulation drives immunothrombosis.
Abstract: https://www.medrxiv.org/content/10.64898/2026.02.28.26346627v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.02.28.26346627v1.full-text
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Search Authors: Yichen Long Yang Ou Guangxiang Huang Xin Tan Shengyan Zhao Lang Min Chunyan Sun Zeyu Luo Hui Pan, 
    GENETICS    IMMUNE   

Mrh09-022

Phenotype-specific associations of mosaic chromosomal alterations in systemic sclerosis

Quote:Conclusions Loss and mLOX were significantly and differentially associated with SSc and its subtypes, underscoring potential phenotype-specific contributions of mCAs.
Abstract: https://www.medrxiv.org/content/10.64898/2026.03.02.26347384v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.03.02.26347384v1.full-text
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Search Authors: Yuki Nishio Yuki Ishikawa Shunsuke Uchiyama Xiaoxi Liu Seiya Takada Tomoki Kuroshima hajime Yoshifuji Masanari Kodera Mitsuteru Akahoshi Hiroaki Niiro Sei-ichiro Motegi Minoru Hasegawa Yoshihide Asano Shingo Nakayamada Yoshiya Tanaka Yuriko N Koyanagi Keitaro Matsuo Yasushi Kawaguchi Masataka Kuwana Issei Imoto Yukie Yamaguchi Chikashi Terao, 

  Javilk's Research Links for Week 09
Updated 03/07/2026-12:02:44 AM
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