Research
Topics:
INDEX
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PRIME 13
aging 5
body 2
brain 6
cancer 5
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covid-19 3
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vaccine 3
virus 2
 
Scanned: 2656
Evaluated: 168
Selected: 44

 
    IMMUNE    VIRUS   

Aac09-001

Scientists create universal nasal spray vaccine that protects against COVID, flu, and pneumonia

Quote:Instead of copying part of a virus or bacterium, this new vaccine imitates the communication signals immune cells exchange during infection. By doing so, it links the bodys two main defense systems -- innate and adaptive immunity -- into a coordinated and longer lasting response. ..., The new formulation, currently called GLA-3M-052-LS OVA, is designed to replicate the T cell signals that stimulate innate immune cells in the lungs. It also includes a harmless antigen, an egg protein known as ovalbumin or OVA, which draws T cells into the lungs and helps sustain the boosted innate response for weeks to months.
Article: https://www.sciencedaily.com/releases/2026/02/260222092258.htm
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    GENETICS    HEART    IMMUNE   

Mhe09-022

Genetic insights into immunothrombosis: from shared loci to repurposed drugs for autoimmune and thrombotic diseases

Quote:Colocalization confirmed that shared genetic susceptibility is primarily driven by expression in arterial tissues aorta and coronary rather than exclusively in immune cells. Furthermore, the lead SNP rs4129267 was identified as a potential predictor for VTE in rheumatoid arthritis patients, and drug prioritization nominated TNF inhibitors as promising candidates for mitigating thrombotic burden. Conclusion This study establishes the first genomic atlas of the autoimmune-thrombotic axis, demonstrating that vasculature-specific gene regulation drives immunothrombosis.
Abstract: https://www.medrxiv.org/content/10.64898/2026.02.28.26346627v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.02.28.26346627v1.full-text
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Search Authors: Yichen Long Yang Ou Guangxiang Huang Xin Tan Shengyan Zhao Lang Min Chunyan Sun Zeyu Luo Hui Pan, 
    BRAIN    IMMUNE   

Mpt09-024

Robust Immunohistochemical Detection of -Synuclein, Tau, and -Amyloid in Human Brain Tissue Archived for up to 78 Years

Quote:Conclusion Human brain tissue preserved as paraffin-embedded blocks or stored in fixative for up to 78 years remains suitable for immunohistochemical analyses. Adequate-to-good detection of aggregated of -synuclein, hyperphosphorylated tau and amyloid- is achievable, indicating preserved pathological hallmarks of Lewy Body Disease and Alzheimers Disease in archival tissue.
Abstract: https://www.medrxiv.org/content/10.64898/2026.02.26.26345861v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.02.26.26345861v1.full-text
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Search Authors: Mie Kristine Just Kristina Bang Christensen Martin Wirenfeldt Torben Steiniche Laura Parkkinen Liisa Myllykangas Per Borghammer, 
    GENETICS    IMMUNE   

Mrh09-022

Phenotype-specific associations of mosaic chromosomal alterations in systemic sclerosis

Quote:Conclusions Loss and mLOX were significantly and differentially associated with SSc and its subtypes, underscoring potential phenotype-specific contributions of mCAs.
Abstract: https://www.medrxiv.org/content/10.64898/2026.03.02.26347384v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.03.02.26347384v1.full-text
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Search Authors: Yuki Nishio Yuki Ishikawa Shunsuke Uchiyama Xiaoxi Liu Seiya Takada Tomoki Kuroshima hajime Yoshifuji Masanari Kodera Mitsuteru Akahoshi Hiroaki Niiro Sei-ichiro Motegi Minoru Hasegawa Yoshihide Asano Shingo Nakayamada Yoshiya Tanaka Yuriko N Koyanagi Keitaro Matsuo Yasushi Kawaguchi Masataka Kuwana Issei Imoto Yukie Yamaguchi Chikashi Terao, 
    IMMUNE   

Mrh09-024

Expanding the clinical spectrum of autoimmune inflammatory myopathies with prominent B cell aggregates: a case series

Abstract: https://www.medrxiv.org/content/10.64898/2026.03.01.26347357v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.03.01.26347357v1.full-text
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Search Authors: barath ramanathan Hao Cheng Shen Marie Hudson Yves Troyanov Oceane Landon-Cardinal Genevieve Gyger Erin OFerrall Benjamin Ellezam Jason Karamchandani Celia Del Carmen Crespo Dominique Jean Zoe Gerber Marilyne Labrie Valerie Leclair Hugues Allard-Chamard, 
    IMMUNE   

Mrh09-026

Airborne particulate matter enhances with monosodium urate crystals the secretion of IL-1 by human immune cells

Quote:A substantial number of gout patients do not report a dietary trigger, and observational studies associate airborne particulate matter with incident gout and flares. Airborne particulate matter contains LPS and airborne-derived particulate matter stimulates IL-1#946; secretion in cell culture.
Abstract: https://www.medrxiv.org/content/10.64898/2026.02.26.26347218v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.02.26.26347218v1.full-text
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Search Authors: Atefeh Razazan Marilyn E Merriman Nandi Burden Richard J Reynolds Leo AB Joosten Salik Hussain Tony R Merriman, 
    PRIME    CULTURE    IMMUNE   

Zza09-006

Tattoos Are Filthy With Toxins, And A Health Risk

Quote:The immune system perceives tattoo ink as a foreign substance because it is. Macrophages the scavenger cells of the immune system engulf the pigment particles. Then they die and release the particles again. ... The November 2025 PNAS study provided the mechanistic link: tattoo ink parks inside lymph node macrophages, the macrophages die in an inflammatory cascade, and the dying cells trigger long-term immune disruption.
Article: https://principia-scientific.com/tattoos-are-filthy-with-toxins-and-a-health-risk/
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  Javilk's Research Links for Week 09
Updated 03/07/2026-12:02:44 AM
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