Research
Topics:
INDEX
AI-chat 7
PRIME 20
aging 9
brain 8
brainwave 2
cancer 5
censorship 1
climate 1
cognition 4
covid-19 1
culture 1
dental 1
diabetes 3
economy 5
exercise 1
gender 1
genetics 1
gut 1
heart 10
herbs 1
immune 4
kidneys 2
language 1
law 1
lungs 3
metabolism 1
microbiome 1
misc
nutrition 7
politics 5
pollution 1
population 1
psychology 1
reproduction 3
sleep 1
soc-media
space 1
unk
vaccine 2
virus 2
war-confl
 
Scanned: 2665
Evaluated: 236
Selected: 60
 
    PRIME    AGING    BRAIN    NUTRITION   

Aaa11-000

Health Benefits of Vitamin B 12

Quote:Low vitamin B12 impact on brain aging A recent study in the June 2025 issue of the journal Annals of Neurology researchers suggested that low blood levels of vitamin B12 are associated with increased risk for cognitive impairment and dementia. While it has b een generally accepted that there is an association between B12 deficiency and neurological dysfunction, this studys objective was to assess whether B12 levels within the current normal range in a cohort of healthy older adults may be associated with measurable evidence of neurological injury or dysfunction.
Article: https://richardgoldberg.substack.com/p/health-benefits-of-vitamin-b-12
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Search Authors: Richard Goldberg,  Felton Nutrition, 
    PRIME    AGING    BRAIN   

Aaa11-034

A brain-persistent DDR2-degrading antibody reverses Alzheimers pathologies by restoring brain fluid dynamics and metabolic clearance

Quote:CONCLUSION This study identifies DDR2 as a master regulator of multi-compartmental failure in AD, orchestrating dysfunction across cerebral vasculature, CSF dynamics, and the choroid plexus. We developed a monoclonal antibody that drives durable internalization and lysosomal degradation of DDR2; when delivered via a neuron-tropic AAV, it achieves sustained CNS expression and confers broad therapeutic efficacy against AD. A companion DDR2-targeted PET tracer enables noninvasive visualization of target engagement in vivo. Together, this integrated platform establishes a new paradigm for disease-modifying therapy in AD.
Abstract: https://www.medrxiv.org/content/10.64898/2026.03.17.26348575v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.03.17.26348575v1.full-text
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Search Authors: Penghui Yang xu chen jiuyang Ding yuzhou Peng zhixiang Lei Jin Su, 
    BRAIN    COGNITION   

Mne11-004

Predicting monopolar local field potential power from bipolar recordings in deep brain stimulation

Quote:This study demonstrates that monopolar LFP power can be accurately estimated from bipolar power using a linear regression model with strong generalizability across targets and validation sets. This approach offers a hardware-agnostic solution to spatially disambiguate signals and better inform DBS programming and adaptive stimulation in chronically implanted devices.
Abstract: https://www.medrxiv.org/content/10.64898/2026.03.13.26348345v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.03.13.26348345v1.full-text
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Search Authors: Chance Fleeting Griffin Lamp Kara A Johnson Jackson Cagle Coralie de Hemptinne Aysegul Gunduz Joshua Wong, 
    AGING    BRAIN    IMMUNE   

Mne11-014

Single-cell multi-omic profiling allows the dissection of peripheral immune phenotypes in Alzheimers Disease progression

Quote:Classical monocytes expanded in mild cognitive impairment and early AD dementia, acquiring a NF-kB/AP-1-mediated low-grade inflammation phenotype. Our findings link peripheral dysregulation in innate and adaptive immunity at cell frequency, transcriptional and epigenetic levels to the AD trajectory and provide insights into distinct phenotypes that define AD progression in contrast to healthy aging across cohorts.
Abstract: https://www.medrxiv.org/content/10.64898/2026.03.12.26348228v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.03.12.26348228v1.full-text
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Search Authors: Jannis B Spintge Karola Mai Caterina Carraro Martina van Uelft Francesco Elli Karoline Mauer Lisa Holsten Aleksej Frolov Janice Elangikal Emily Hinkley Jonas Schulte-Schrepping Mehrnoush H Shakiba Laura Lang Tarek Elmzzahi Doaa Hamada Sophie Mller Yuanfang Li Ioanna Gemnd Charlotte Krger Jacqueline Leidner Timo Zajac Jessica V Montgomery Celia Hartmann Bidour Hussein Maren Bttner Rainer Knoll Dina Hsson Rebekka Scholz Tobias Paschek Victoria Isakzai Nico Reusch Stefan Paulusch Anna Drews Michael Kraut Heidi Theis Marie Rthing Ulrike Strube Lukas Preis Daria Gref Eike J Spruth Maria Gemenetzi Klaus Fliessbach Niels Hansen Ayda Rostamzadeh Wenzel Glanz Enise I Incesoy Daniel Janowitz Sophia Stcklein Boris-Stephan Rauchmann Ingo Kilimann Doreen Goerss Sebastian Sodenkamp Marie Kronmller Sandra Roeske Anna Gamez Matthias Schmid Katharina Brger Julian Hellmann-Regen Christoph Laske Alfredo Ramirez Frederic Brosseron Jens Wiltfang Robert Perneczky Emrah Dzel Stefan Teipel Annika Spottke Gabor C Petzold Oliver Peters Josef Priller Susanne V Schmidt Michael Wagner Luca Kleineidam Frank Jessen Anja Schneider Lorenzo Bonaguro Elena De Domenico Anna C Aschenbrenner Matthias Becker Thomas Ulas Joachim L Schultze Marc D Beyer, 
    AGING    BRAIN    SLEEP   

Mne11-016

Vascular brain injury modifies the relationship between sleep duration, cognition, and white matter hyperintensity burden in the Alzheimers disease continuum

Quote:INTRODUCTION Self-reported sleep duration is associated with dementia-risk and vascular brain injury markers, including white matter hyperintensities WMHs, DISCUSSION Additional vascular brain injury modifies how sleep relates to WMH burden and cognition across the AD continuum, highlighting the importance of moving beyond WMHs alone.
Abstract: https://www.medrxiv.org/content/10.64898/2026.03.12.26348239v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.03.12.26348239v1.full-text
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Search Authors: Soraya Lahlou Zahinoor Ismail Eric E. Smith Thien Thanh Dang-Vu AmanPreet Badhwar, 
    PRIME    AGING    BRAIN    BRAINWAVE    COGNITION   

Mne11-018

Theta deep-brain stimulation improves cognitive performance in Parkinsons patients with cognitive impairments

Quote:Conclusions These data suggest that theta-frequency 4 Hz STN stimulation is effective in PD patients with cognitive impairments. Our findings will help guide new therapies targeted at improving cognitive dysfunction in PD and could broaden applications for low-frequency brain stimulation. ### Competing Interest Statement
Comment: I find that the Schuman frequency, the general frequency of the geomagnetic field oscillations averaging 7.83hz, is more more effective in improving memory, while anything below 5hz physiologically impares memory formation and induces sleep mode paralysis top prevent sleep-walking, etc.
Abstract: https://www.medrxiv.org/content/10.64898/2026.03.12.26348246v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.03.12.26348246v1.full-text
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Search Authors: Rachel C. Cole James F. Cavanagh Qiang Zhang Christopher L. Groth Juan Vivanco-Suarez Arturo I. Espinoza Jeremy D. Greenlee Nandakumar S Narayanan, 
    BRAIN   

Mpy11-004

A Novel Therapeutic Mechanism for Nicotine Craving in Schizophrenia

Quote:Default mode network DMN pathology is linked to tobacco use in schizophrenia, and transcranial magnetic stimulation TMS applied to the DMN affects craving in schizophrenia.
Abstract: https://www.medrxiv.org/content/10.64898/2026.03.14.26348404v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.03.14.26348404v1.full-text
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Search Authors: Heather Burrell Ward Jillian Connolly Sophia H Blyth Simon Vandekar Baxter P Rogers Mark A Halko Catie Chang Hilary A Tindle L Elliot Hong A Eden Evins Stephan Heckers Roscoe O Brady span classnlm-suffixJr., 
    PRIME    BRAIN    BRAINWAVE    PSYCHOLOGY   

Mpy11-010

Pilot Randomized Trial of Intermittent Theta-Burst Stimulation versus H-Coil Transcranial Magnetic Stimulation for Treatment-Resistant Depression

Quote:Conclusion: In this pilot trial, iTBS and H7-coil rTMS showed symptom improvement, with no clear between-group pattern. Exploratory findings suggest a potential signal involving executive functioning that warrants further investigation. These results inform the feasibility and design of larger comparative trials. ... Response rates were 40.0 for iTBS and 50.0 for H-coil p.60, and remission rates were identical across groups 20.0. Remitters showed higher baseline executive functioning than non-remitters in exploratory analyses, although these associations were not confirmed in adjusted models.
Comment: Even weak (20ma) current from an electronics type signal generator fed through a 20 turn magnet wire coil has physiological effectswhich depend on frequency. Other means include modulating a heat lampusing a solid state switch. My experiments on my non-depressed self show positive mood changes wen used at the Schuman (7.83Hz) frequency. These are things any tech-savy person can do for themselves. Email me at this site to discuss.
Abstract: https://www.medrxiv.org/content/10.64898/2026.03.13.26348335v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.03.13.26348335v1.full-text
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Search Authors: Veronique Desbeaumes Jodoin Emma Bousseau Francois Trottier-Duclos Didier Jutras-Aswad Francois Lesperance Dang Khoa Nguyen Elie Bou Assi Daniel M. Blumberger Martijn Arns Travis E. Bakert Zafiris Daskalakis Paul Lesperance Jean-Philippe Miron, 

  Javilk's Research Links for Week 11
Updated 03/20/2026-10:37:02 PM
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