Research
Topics:
INDEX
AI-chat 5
PRIME 20
aging 9
brain 12
brainwave 2
cancer 8
catastrophy 1
cognition 8
covid-19 3
crime 1
culture 3
dental 3
diabetes 3
diagnostics 3
economy 5
exercise 1
eyes 1
genetics 6
gut 2
heart 5
herbs 1
immune 3
kidneys 1
language 2
law 3
lung 1
metabolism 2
microbiome 1
nutrition 7
pain 4
physical 3
politics 1
pollution 1
practice 1
privacy 2
psychology 13
radiation 1
religion 1
rights 1
sleep 2
soc-media
stress 2
unk
virus 1
war-confl
 
Scanned: 2629
Evaluated: 248
Selected: 73
 
    PRIME    BRAIN    COGNITION    PSYCHOLOGY   

Aaa12-004

Oxidative Stress May Drive Repetitive Behaviors Linked to Autism, OCD

Quote:Summary: A new study shows that oxidative stressan imbalance between damaging molecules and antioxidantsmay contribute to repetitive behaviors observed in mice, similar to those seen in autism spectrum disorder and schizophrenia. Researchers found that higher levels of oxidative stress biomarkers, including glutathione and specific proteins, were linked to more severe stereotypies in young mice. These protein profiles were consistent across different mouse strains, suggesting a robust biological connection. The findings reveal new potential biomarkers and therapeutic targets for repetitive behavior disorders, though more research is needed to confirm whether antioxidant treatments could help.
Comment: The brain concentrates C in the body. The first things I noticed when taking vitamin C at near bowel tolerance levels, is improved brain function, deeper perception and better memory.
Article: https://neurosciencenews.com/oxidative-stress-asd-ocd-29902/
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See Also:
  • http://mall-net.com/cathcart/titrate.html
    •     AGING    COGNITION   

    Mge12-038

    Biological age acceleration measured by DunedinPACE associates most consistently with cognitive decline in elderly individuals

    Quote:Results: Among all tested DNAm clocks, DunedinPACE a third-generation clock showed the strongest and most consistent associations with cognitive performance. In addition, the fifth-generation SystemsAge framework also demonstrated robust associations with cross-sectional and longitudinal cognitive outcomes. In contrast, second-generation clocks GrimAge v2, PhenoAge showed occasional nominal associations, while first-generation clocks Horvath v1, Hannum and the causally-informed, fourth-generation clocks e. g. YingCausAge, YingDamAge showed no noteworthy signals. Likewise, telomere length estimated from DNAm was not strongly associated with cognitive performance in this dataset. Conclusions: Our findings highlight DunedinPACE as a particularly informative biomarker for various aspects of cognitive aging, while other DNAm aging measures showed no consistent associations.
    Abstract: https://www.medrxiv.org/content/10.64898/2026.03.23.26349074v1
    Full Text: https://www.medrxiv.org/content/10.64898/2026.03.23.26349074v1.full-text
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    Search Authors: Anna Marit Weissenburg Marit Philine Junge Jan Homann Valerija Dobricic Valentin Max Vetter Ulman Lindenberger Christina M Lill Ilja Demuth Sandra Duezel Lars Bertram, 
        AGING    BRAIN    COGNITION    HEART   

    Mne12-010

    Middle aged carotid plaque and cognitive functions in later life: a population-based study. Middle aged carotid plaque and cognitive functions in later life: a population-based study.

    Quote:Discussion: In this large cohort study, carotid plaque status at baseline was independently associated with in cognitive function decline, especially in non-verbal memory and executive functioning over 8-year follow-up period in the general population. Therefore, it may be important for earlier intervention on carotid plaque to preserve neurological health in middle-aged to older population.
    Abstract: https://www.medrxiv.org/content/10.64898/2026.03.23.26349039v1
    Full Text: https://www.medrxiv.org/content/10.64898/2026.03.23.26349039v1.full-text
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    Search Authors: Gisung Shin Ali Tanweer Siddiquee Min-Hee Lee June Christoph Kang Yoonho Hwang Seungku Lee Bongjo Kim Youngjin Kim Chol Shin Nanhee Kim Gisung Shin Ali Tanweer Siddiquee Min-Hee Lee June Christoph Kang Yoonho Hwang Seungku Lee Bongjo Kim Youngjin Kim Chol Shin Nanhee Kim, 
        AGING    BRAIN    COGNITION   

    Mne12-020

    The Case Against the S: Is Functional Neurological Disorders One Condition or Many? The Case Against the S: Is Functional Neurological Disorders One Condition or Many?

    Quote:Our results suggest that the symptom structure of FND is the result of a single pathophysiological process, either as a single entity, or a common pathway preceded by multiple causative processes where the common pathway is solely responsible for the phenotype of the condition.
    Abstract: https://www.medrxiv.org/content/10.64898/2026.03.19.26348846v1
    Full Text: https://www.medrxiv.org/content/10.64898/2026.03.19.26348846v1.full-text
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    Search Authors: David D. G. Palmer Mark J. Edwards Jason Mattingley David D. G. Palmer Mark J. Edwards Jason Mattingley, 
        COGNITION    PAIN   

    Mpa12-024

    Working memory in chronic pain: evidence for task-specific rather than global differences

    Quote:Diffusion modelling showed no evidence for sensory/motor slowing, but rather greater response caution in the auditory-temporal task and small efficiency drift rate reductions in low-load visual conditions. The results do not support a global working-memory capacity loss account in this mixed chronic pain sample. Rather, they suggest task-specific performance differences, most evident in auditory-temporal processing, with response caution as a plausible contributor.
    Abstract: https://www.medrxiv.org/content/10.64898/2026.03.20.26348805v1
    Full Text: https://www.medrxiv.org/content/10.64898/2026.03.20.26348805v1.full-text
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    Search Authors: Monika Halicka Meike Scheller Christopher A Brown, 
        AGING    COGNITION    PSYCHOLOGY   

    Mpy12-036

    Invisible by Design: Three Mechanisms That Render Dementia Undetectable in Correctional Statistics Across Four High-Income Countries

    Quote:Interpretation Correctional mental health statistics across four high-income countries are structurally incapable of detecting dementia not through clinical ignorance but by design: systems built for younger populations that have not been updated as prison demographics have changed. Japans ageing female theft offender profile 39.4 aged 60 or older, 35.0 with low cognitive scores represents a potential sentinel population for undetected cognitive impairment. Targeted interventions cognitive screening at admission in the United States and Australia, introduction of a dementia classification category in Japan, and routine mental health data publication in the United Kingdom are feasible with existing infrastructure. As prison populations continue to age, the statistical invisibility of dementia constitutes an escalating failure of health surveillance with direct consequences for clinical care, sentencing, and human rights.
    Abstract: https://www.medrxiv.org/content/10.64898/2026.03.20.26348939v1
    Full Text: https://www.medrxiv.org/content/10.64898/2026.03.20.26348939v1.full-text
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    Search Authors: Hiroki Fukui, 
        COGNITION    PSYCHOLOGY   

    Mpy12-038

    Supporting women who have served in the Armed Forces with a smartphone app to reduce alcohol consumption: A Randomized Controlled Trial

    Quote:Conclusions DrinksRation reduced alcohol consumption and hazardous drinking among women who have served in the UK Armed Forces. Engagement was strong, usability was high, and no safety concerns were identified. These findings support the potential of tailored digital interventions to address alcohol misuse in women who have served in the UK Armed Forces. Registration ClinicalTrials.gov1 trial registration: NCT059704842.
    Abstract: https://www.medrxiv.org/content/10.64898/2026.03.22.26349029v1
    Full Text: https://www.medrxiv.org/content/10.64898/2026.03.22.26349029v1.full-text
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    Search Authors: Grace Williamson Ewan Carr Rhea Varghese Simon Dymond Kate King Amos Simms Laura Goodwin Dominic Murphy Daniel Leightley, 
        COGNITION    IMMUNE   

    Mrh12-002

    Autoimmunity and Arthritis in Youth with Autism and Suspected Post-Infectious Deteriorations

    Quote:In this cohort study of 43 patients with autism spectrum disorder ASD and suspected post-infectious deteriorations, more than half had laboratory markers of immune activation using a limited panel, one-third had joint inflammation confirmed by ultrasound, and additional autoimmune conditions were observed in 21. From this, we conclude that patients with ASD who experience a suspected post-infectious neuropsychiatric deterioration may have underlying inflammation which may contribute to neuropsychiatric and behavioral regressions, highlighting the importance of immunologic and rheumatologic evaluation in clinical assessment.
    Abstract: https://www.medrxiv.org/content/10.64898/2026.03.19.26348838v1
    Full Text: https://www.medrxiv.org/content/10.64898/2026.03.19.26348838v1.full-text
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    Search Authors: Meiqian Ma Noelle Schlenk Jesse Sandberg Zadie Schaffer Kate Miles Cindy Manko Bahare Farhadian Kayla Azad Christy Capestany Abhinay Aeruva Yuhuan Xie Paula Tran Melissa Silverman Kevin W Hoffman Margo Thienemann Jennifer Frankovich, 

      Javilk's Research Links for Week 12
    Updated 03/27/2026-11:59:04 PM
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