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DIABETES
KIDNEYS
METABOLISM
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Mcr13-024 | Association of Modified Cardiometabolic Index with Cardiovascular-Kidney-Metabolic Syndrome Staging, All-Cause Mortality, and Cardiovascular Mortality: A Population-Based Cohort Study |
| Quote: | Objective To investigate the association of the modified cardiometabolic index MCMI with cardiovascular-kidney-metabolic CKM syndrome staging, all-cause and cardiovascular mortality, and compare its predictive performance with traditional indices. ... Conclusions MCMI is an independent predictor of CKM progression and mortality. Its cardiovascular mortality risk is predominantly mediated by diabetes.
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| Abstract:
| https://www.medrxiv.org/content/10.64898/2026.03.30.26349722v1 |
| Full Text:
| https://www.medrxiv.org/content/10.64898/2026.03.30.26349722v1.full-text |
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Yuqi Qin, Yibo Yan,
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PRIME
AGING
COGNITION
GENETICS
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Mge13-012 | Genetic and epigenetic regulation of SLC6A4 shapes vulnerability to cognitive decline and depressive tendency in later life |
| Quote: | DNA methylation at a functional promoter CpG site increased with age and partially mediated age-related cognitive decline specifically among low-activity genotypes. In contrast, the high-activity genotype was associated with relative resistance to these functional declines, partly mediated by a protective effect on hippocampal volume during aging. Notably, genotype-dependent effects on hippocampal volume were absent in adolescence, indicating that the influence of SLC6A4 emerges in an aging-specific manner. Together, these findings identify SLC6A4 promoter activity as a key genetic factor modulating vulnerability and resilience in later life.
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| Abstract:
| https://www.medrxiv.org/content/10.64898/2026.03.26.26349121v1 |
| Full Text:
| https://www.medrxiv.org/content/10.64898/2026.03.26.26349121v1.full-text |
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The+Japan+Prospective+Studies+Collaboration+for+Aging+and+Dementia+(JPSC-AD)+study+group&t=50" TARGET=auth>Yutaro Yanagida, Yutaka Nakachi, Naoto Kajitani, Satoshi Kikkawa, Tempei Ikegame, Shinsuke Koike, Norihide Maikusa, Naohiro Okada, Izumi Naka, Jun Ohashi, Hiroko Sugawara, Kazuhiro Yoshiura, Ayaka Fujii, Emi Kiyota, Risa Watanabe, Yui Murata, Yasuyuki Taki, Yasuko Tatewaki, Benjamin Thyreau, Yuji Takano, Manabu Makinodan, Norio Sakai, Tomohisa Ishikawa, Yosuke Hidaka, Mamoru Hashimoto, Yoshihiko Furuta, Tomoyuki Ohara, Toshiharu Ninomiya, Kiyoto Kasai, Minoru Takebayashi, Miki Bundo, Kazuya Iwamoto, span class="nlm-collab" data-hwp-id="collab-1">The Japan Prospective Studies Collaboration for Aging and Dementia (JPSC-AD) study group,
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AGING
IMMUNE
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Min13-038 | Streptococcus agalactiae, a frequent but not so well-known cause of bone and joint infections: a Multicentric observational study 2014-23 |
| Quote: | Conclusion S. agalactiae emerges as a prominent and distinct pathogen in complex streptococcal BJIs, with specific risk factors such as arteriopathy, obesity and diabetes mellitus, and more chronic infections.
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| Abstract:
| https://www.medrxiv.org/content/10.64898/2026.03.30.26349534v1 |
| Full Text:
| https://www.medrxiv.org/content/10.64898/2026.03.30.26349534v1.full-text |
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Simon Jamard, gwenael Le Moal, chloe Plouzeau-Jayle, Cedric Arvieux, Sophie Ressier, raphael Lecomte, Stephane Corvec, Severine Ansart, Claudie Lamoureux, Pierre Abgueguen, Rachel Chenouard, Marie Frederique Lartigue, Adrien Lemaignen,
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AGING
LANGUAGE
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Mne13-010 | Cognitive and brain reserve in bilingual speakers with clinical AD variants |
| Quote: | Cognitive performance in monolinguals and bilinguals was comparable within variants. DISCUSSION: Bilingualism may support cognitive reserve preserved cognition despite reduced GMV in both AD variants, with additional brain reserve in lvPPA.
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| Abstract:
| https://www.medrxiv.org/content/10.64898/2026.03.27.26349575v1 |
| Full Text:
| https://www.medrxiv.org/content/10.64898/2026.03.27.26349575v1.full-text |
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Nicoletta Biondo, John Matthew Suntay, Muskaan Sandhu, Jeanine Sandra Estaban, Janhavi Pillai, Maria Luisa Mandelli, Eugenie Mamuyac, Rochelle-Jan Dionisio Reyes, Ariel Guevarra, Maya L Henry, Nina F. Dronkers, Stephanie Grasso, Jessica de Leon,
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AGING
BRAIN
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Mne13-012 | Predicting long term clinical outcomes in Parkinsons Disease using short term rating scales |
| Quote: | Conclusions: We have demonstrated how a treatment effect in a trial specified in terms of a progression change of a rating scale can be contextualised into a long-term reduction in the probability of clinically relevant milestones.
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| Abstract:
| https://www.medrxiv.org/content/10.64898/2026.03.27.26349548v1 |
| Full Text:
| https://www.medrxiv.org/content/10.64898/2026.03.27.26349548v1.full-text |
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Matthew Burnell, Cristina Gonzalez-Robles, Marie-Louise Zeissler, Michele Bartlett, Caroline S Clarke, Carl Counsell, Michele T Hu, Tom Foltynie, Camille Carroll, Michael Lawton, Yoav Ben-Shlomo, James Carpenter,
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AGING
GENETICS
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Mne13-016 | Bridging Genetics and Precision Medicine in Parkinsons Disease through GP2 |
| Quote: | GP2s unified framework supports equitable recruitment for gene-targeted therapeutic studies and helps address critical gaps in Parkinsons disease genetics and future therapeutic development.
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| Abstract:
| https://www.medrxiv.org/content/10.64898/2026.03.26.26349418v1 |
| Full Text:
| https://www.medrxiv.org/content/10.64898/2026.03.26.26349418v1.full-text |
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the+Global+Parkinson's+Genetics+Program+(GP2)&t=50" TARGET=auth>Kajsa Atterling Brolin, Lara M Lange, Emily Navarro-Jones, Simona Jasaityte, Yuan Ye Beh, Zih-Hua Fang, Hirotaka Iwaki, Lietsel Jones, Christine Klein, Teresa Kleinz, Hampton L Leonard, Ignacio Mata, Alastair Noyce, Njideka U Okubadejo, Paula Saffie Awad, Laurel Screven, Ai Huey Tan, Marco Toffoli, Dan Vitale, Andrew Singleton, Cornelis Blauwendraat, Mike A Nalls, Huw Morris, span class="nlm-collab" data-hwp-id="collab-1">the Global Parkinson's Genetics Program (GP2),
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AGING
BRAIN
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Mne13-018 | Plasma pTau217 as a Prognostic, Monitoring, and Risk-Stratification Biomarker of Clinical Progression in Lewy Body Disease |
| Abstract:
| https://www.medrxiv.org/content/10.64898/2026.03.26.26349399v1 |
| Full Text:
| https://www.medrxiv.org/content/10.64898/2026.03.26.26349399v1.full-text |
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S. A. Lorkiewicz, C. Abdelnour, M. Bolen, A. M. Smith, M. Shahid-Besanti, D. Hemachandra, E. M. Müller-Oehring, N. Siddiqui, L. Montoliu-Gaya, B. Arslan, N. J. Ashton, E. N. Wilson, L. Tian, K. I. Andreasson, E. C. Mormino, V. W. Henderson, H. Zetterberg, K. L Poston,
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AGING
BRAIN
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Mne13-022 | Abnormalities in core AD biomarkers precede inflammatory and glial markers in CSF in Autosomal Dominant Alzheimers Disease |
| Quote: | INTERPRETATION: Our results suggest that the main CSF proteomic landscape changes in ADAD are due to the presence of a pathogenic mutation and occur prior to symptom onset. Improved performance of multi-protein composite to predict EYO compared to single biomarker values highlights the added value of multiplex proteomic signatures for biomarker panel development.
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| Abstract:
| https://www.medrxiv.org/content/10.64898/2026.03.31.26349851v1 |
| Full Text:
| https://www.medrxiv.org/content/10.64898/2026.03.31.26349851v1.full-text |
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Wenjing Lin, Aleksandra Beric, Julie K Wisch, Bryce Baker, Gina Jerome, Matthew Minton, Sam Preminger, Jennifer Stauber, Suzanne E Schindler, Jeff Dage, Ricardo Allegri, David Aguillon, Tammie Benzinger, Jasmeer Chhatwal, Alisha Daniels, Gregory Day, Emma Devenney, Nick Fox, Alison Goate, Brian Gordon, Jason Hassenstab, Edward Huey, Takeshi Ikeuchi, Suman Jayadev, Mathias Jucker, Takanobu Ishiguro, Jae-Hong Lee, Allan Levey, Johannes Levin, John C Morris, Richard Perrin, Alan Renton, Jee Hoon Roh, Chengjie Xiong, Randall J Bateman, Beau Ances, Carlos Cruchaga, Celeste Karch, Charlene Supnet-Bell, Jorge J Llibre-Guerra, Eric McDade, Laura Ibanez,
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AGING
BRAIN
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Mne13-024 | NeuroFM: Toward Precision Neuroimaging with Foundation Models for Individualized Brain Health Estimation |
| Quote: | Evaluated on 136,361 multi-cohort volumes, NeuroFM generalizes across domains and enables individual-level brain health profiling, estimating future dementia risk years before diagnosis. Together, these findings establish a disease-naive foundation model for precision neuroimaging with potential to support quantitative brain health assessments across settings.
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| Abstract:
| https://www.medrxiv.org/content/10.64898/2026.03.27.26349489v2 |
| Full Text:
| https://www.medrxiv.org/content/10.64898/2026.03.27.26349489v2.full-text |
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Austin Dibble, Connor Dalby, Michele Sevegnani, Alessio Fracasso, Donald M Lyall, Monika Harvey, Michele Svanera,
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AGING
DISEASE
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Mne13-028 | Design-induced artifacts when disease clocks are plugged into second-stage analyses of symptom onset |
| Quote: | Conclusion: The apparent predictive ability of plasma p-tau217 disease clocks is driven largely by structural age relationships rather than independent biomarker signal.
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| Abstract:
| https://www.medrxiv.org/content/10.64898/2026.03.26.26349230v1 |
| Full Text:
| https://www.medrxiv.org/content/10.64898/2026.03.26.26349230v1.full-text |
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Philip Insel, Michael C Donohue,
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AGING
NUTRITION
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Mnu13-026 | Ultra-processed food consumption and frailty in older adults: a systematic review and meta-analysis |
| Quote: | Meta-analysis showed that higher consumption of UPFs was significantly associated with an increased risk of frailty
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| Abstract:
| https://www.medrxiv.org/content/10.64898/2026.03.29.26349639v1 |
| Full Text:
| https://www.medrxiv.org/content/10.64898/2026.03.29.26349639v1.full-text |
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Min Pu, Qianying Ma,
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PRIME
AGING
COGNITION
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Zzb13-000 | Is Methylene Blue the Secret Weapon for Fighting Alzheimers and Keeping Your Brain Young? |
| Comment:
| Works for some peoople, others say they have not had much success with it. there are some interesting youtube videos on the subject.
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| Article:
| https://www.thegatewaypundit.com/2026/03/is-methylene-blue-secret-weapon-fighting-alzheimers-keeping-17/ |
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