Research
Topics:
INDEX
AI-chat 7
PRIME 20
aging 5
brain 8
cancer 12
climate 3
cognition 5
covid-19 2
crime 2
dental 2
diabetes 6
disease 2
economy 3
eyes 1
gender 1
genetics 7
heart 6
kidneys 1
language 1
lungs 2
metabolism 4
microbiome 1
nutrition 7
obesity 1
pain 4
physical 1
politics 2
pollution 1
privacy 1
psychology 7
radiation 1
reproduction 4
rights 1
sleep 1
soc-media
stress 1
virus 2
war-confl
 
Scanned: 1426
Evaluated: 167
Selected: 66

 
    PRIME    BRAIN    CLIMATE    NUTRITION    PSYCHOLOGY   

Aaa14-002

The Molecule You were Taught was Waste is what your Brain needs Most

Quote: The Bohr Effect releases more oxygen to brain tissue where needed....

Cerebral hypoxia from too much breathing creates lightheadedness, tingling, sense of unreality...

driven by CO2 driven off by rapid breathing.

Comment: If you watch one video, watch this one.

This works. The clarity and the warmth from the Bohr effect is readily felt. CO2 is a potent vasodilator and triggers the release of O2 from the blood where needed. This is why drinking soda gives you a boost. We evolved with several times higher CO2 levels than we have now. It is not just plants that need more CO2, it is all life that needs more CO2.

Article: https://youtube.com/watch?v=co54vGnEHWU
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    BRAIN    MICROBIOME   

Aaa14-003

Exploring the Connection Between Gut Health and Meditation

Quote: The human gut microbiome, comprising trillions of microorganisms, is a cornerstone of every persons physical and mental health. These microorganisms produce neurotransmitters and neuroactive compounds, such as serotonin and gamma-aminobutyric acid (GABA), which help to support our mood and cognitive functioning....

Stress is a well-known aggravator of gut dysfunction, impacting gut motility, barrier function, and the microbiome. Meditation, through its stress-reducing effects, can positively influence gut health by modulating these stress-related changes. It helps to restore the balance of gut bacteria, improving gut barrier function and reducing inflammation.

Comment: Calm reflective thought on the experiences of the day may be better than meditation for ability of the mind to build strategies that encourage relaxation during daily events. Works for me.
Article: https://www.news-medical.net/health/Exploring-the-Connection-Between-Gut-Health-and-Meditation.aspx
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    BRAIN    CANCER   

Mca14-008

PINK1 Expression as a Prognostic Biomarker in Glioblastoma Multiforme: An Observational Multicenter Study

Abstract: https://www.medrxiv.org/content/10.64898/2026.04.03.26350127v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.04.03.26350127v1.full-text
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Search Authors: Luis Alejandro Garcia Rairan span classnlm-suffixSr. valentina Corpus Gutierrez span classnlm-suffixJr. maria alexandra Del castillo span classnlm-suffixJr. Willian Riveros Castillo Javier Saavedra Gerena Andres David Turizo Smith Jaime Arias Guatibonza, 
    BRAIN    GENETICS   

Mge14-004

DNM1-related disorder is characterized by recurrent variants and phenotypic homogeneity

Quote: Results: Disease-causing variants in DNM1 cluster in mutational hotspots within the gene, which achieve Strong and Moderate evidence for pathogenicity based on ACMG guidelines. The overall DNM1 phenotype was homogeneous compared to other genetic epilepsy conditions: SCN2A, SCN8A, STXBP1, and SYNGAP1. The p. R237W (n15) variant was associated with bilateral tonic-clonic seizures, infantile spasms, and dystonia. The p. I398_R399insCR (n14) variant was associated with severe hypotonia, profound global delay, and cortical visual impairment. Five individuals with homozygous loss-of-function variants were clinically similar to dominant-negative DNM1-related disorder, but microcephaly and brain MRI abnormalities were more common in this group.
Abstract: https://www.medrxiv.org/content/10.64898/2026.04.05.26350183v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.04.05.26350183v1.full-text
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Search Authors: Alicia G Harrison Shiva Ganesan Hongbo M Xie Shridhar Parthasarathy Jillian L McKee Jan H Magielski Kim Thalwitzer Rohit Lobo Manuela Pendziwiat Andreas van Baalen Hildtrud Muhle Annapurna Poduri Alisa Mo Gert Wiegand Katrin Ounap Ange-Line Bruel Marcello Scala Valeria Capra Sarah M Ruggiero Ingo Helbig, 
    AGING    BRAIN    COGNITION   

Mne14-006

Beyond Motor Fluctuations: Understanding the Clinical Correlates of OFF burden in Parkinsons Disease

Quote: Results: Clinical features explained more variance in OFF impact than OFF time (25. 9 vs 8. 1). OFF time was primarily linked to OFF state motor severity/freezing, with levodopa responsiveness important early. For OFF impact, predictability produced the largest increment in marginal R squared beyond the core motor model (pooled and Late). Within the core motor model, tremor was the largest contributor to OFF impact. Conclusions: Predictability is a prominent correlate of OFF impact
Comment: OFF is a symptoms flair when the body has used up available dopamine in Parkinsons.
Abstract: https://www.medrxiv.org/content/10.64898/2026.04.04.26350175v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.04.04.26350175v1.full-text
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Search Authors: David Ledingham Sahana Sathyanarayana Robyn Iredale Charlotte Bernadette Stewart Victoria Foster Debra Galley Mark R Baker Nicola Pavese, 
See Also:
  • https://www.healthline.com/health/parkinsons-disease/off-episodes-in-parkinsons-disease-faqs
  •     AGING    BRAIN    COGNITION   

    Mne14-020

    Tau pathological activity in plasma before the onset of symptomatic Alzheimer s disease

    Quote: VeraBIND Tau demonstrated 94.2 sensitivity and 96.1 specificity for predicting tau-PET positivity (AUC0.97). It outperformed plasma pTau217 in CU individuals (PPV85.9), regardless of the pTau217 threshold used (maximal PPV of 57.5 using the 0.256pg/mL pTau217 threshold)....

    These findings highlight the strong potential of VeraBIND Tau as a scalable and accurate screening tool to detect AD tau pathology in the general population. The assay may also help enrich clinical trials with tau-PET positive CU individuals, enhance clinical diagnostic workflows and support monitoring of tau-targeted therapies.

    Abstract: https://www.medrxiv.org/content/10.64898/2026.04.03.26350110v1
    Full Text: https://www.medrxiv.org/content/10.64898/2026.04.03.26350110v1.full-text
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    Search Authors: Bernard J. Hanseeuw Lisa Quenon Jean-Louis Bayart Emilien Boyer Lise Colmant Yasmine Salman Thomas Gerard Lara Huyghe Vincent Malotaux Pascal Kienlen-Campard Flo Blondiaux Pirson Renaud Lhommel Laurence Dricot Adrian Ivanoiu Kavya Shamsundar Winnie Pak Joshua Soldo Khalid Iqbal, 
        BRAIN    PAIN    PSYCHOLOGY   

    Mpy14-014

    Structural brain characteristics of current co-occurring chronic pain and depression: a cross-sectional analysis of UK Biobank

    Quote: Conclusion These results provide a robust characterisation of brain structure alterations in comorbid chronic pain and depression, highlighting a distinct neuroanatomical profile and advancing understanding of its underlying neurobiology.
    Abstract: https://www.medrxiv.org/content/10.64898/2026.04.02.26350033v1
    Full Text: https://www.medrxiv.org/content/10.64898/2026.04.02.26350033v1.full-text
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    Search Authors: Hannah Casey Mark J Adams Andrew M McIntosh Marie T Fallon Daniel J Smith Rona J Strawbridge Heather C Whalley, 
        AGING    BRAIN    PHYSICAL   

    Zza14-007

    Why Walking Backwards FIXES what Forward Walking Breaks

    Quote: Walking backwards revitalizes the brain
    Comment: This stimulates the brain in many ways, increasing coordination for many other actions as well.
    Article: http://youtube.com/watch?=vbUF1mry7i_k
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      Javilk's Research Links for Week 14
    Updated 04/11/2026-01:28:16 AM
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