Research
Topics:
INDEX
AI-chat 1
PRIME 11
aging 12
body 1
brain 14
brainwave 1
cancer 11
climate 1
cognition 4
covid-19 2
culture 6
dental 6
diabetes 9
disease 1
emergency 1
energy 1
eyes 1
genetics 4
gut 2
heart 8
herbs 1
immune 2
kidneys 3
lungs 2
metabolism 3
microbiome 4
nutrition 6
obesity 3
pain 1
politics 4
pollution 4
psychology 9
radiation 1
religion 1
rights 1
unk
virus 3
war-confl
 
Scanned: 1397
Evaluated: 447
Selected: 78
 
    AGING    PSYCHOLOGY   

Mep17-006

Trajectories of Depressive Symptoms Across the Menopause Transition: A Longitudinal Analysis from a Prospective UK Cohort Study

Quote: Conclusions Overall, reproductive ageing appears to contribute relatively little to long-term changes in depressive symptoms beyond the broader effects of chronological ageing. The odds of depression were highest in the perimenopause and did not persist into postmenopause, indicating that this stage may represent a window of vulnerability for a subgroup of women. Identifying such subgroups could help inform targeted prevention and support strategies.
Abstract: https://www.medrxiv.org/content/10.64898/2026.04.27.26351577v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.04.27.26351577v1.full-text
Search Similar: Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho 
Search Authors: Rochelle Knight Carol Joinson Abigail Fraser Ana Gonalves Soares, 
    AGING    BODY    EMERGENCY   

Mep17-012

Inequality in healthy lifespan following surgery: a longitudinal population study

Quote: 5 of elective surgical patients and 2 of emergency surgical patients developed new long-term disease within three years of surgery. Accounting for differences in age, people from the most deprived decile experienced 11 higher rates of elective and 54 higher rates of emergency surgery compared to the least deprived.
Abstract: https://www.medrxiv.org/content/10.64898/2026.04.25.26351729v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.04.25.26351729v1.full-text
Search Similar: Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho 
Search Authors: Yize I Wan Rupert M Pearse John R Prowle, 
See Also:
  • https://www.medrxiv.org/content/10.64898/2026.04.25.26351727v1
    •     AGING    BRAIN    COGNITION   

    Mge17-020

    Behavioral and psychological symptoms of dementia: insights from a multivariate and network-based brain proteome-wide study

    Quote: Behavioral and psychological symptoms of dementia (BPSD) are common, profoundly troubling to patients and caregivers, and difficult to treat, yet their molecular underpinnings remain poorly understood. Here, we generated a large brain proteomic dataset with nine BPSD domains assessed in life from 376 donors from three cohorts.
    Abstract: https://www.medrxiv.org/content/10.64898/2026.04.23.26351110v1
    Full Text: https://www.medrxiv.org/content/10.64898/2026.04.23.26351110v1.full-text
    Search Similar: Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho 
    Search Authors: Selina M. Vattathil Duc M. Duong Marla Gearing Nicholas T. Seyfried Robert S. Wilson David A. Bennett Randall L. Woltjer Thomas S. Wingo Aliza P. Wingo, 
        AGING    DIABETES   

    Mgr17-006

    Prediabetes and glycemic transitions as determinants of frailty and functional decline in adults aged 50 years and older: A longitudinal analysis from five multinational aging cohorts

    Quote: Interpretation Prediabetes is associated with increased risk of functional decline, frailty, and deficit accumulation in older adults, independent of progression to diabetes. Regression to normoglycemia was associated with higher risk of functional deterioration. These findings suggest that prediabetes reflects a state of metabolic vulnerability linked to biological aging rather than solely a precursor to diabetes and highlights a need to reframe its clinical significance in older populations.
    Abstract: https://www.medrxiv.org/content/10.64898/2026.04.22.26351540v1
    Full Text: https://www.medrxiv.org/content/10.64898/2026.04.22.26351540v1.full-text
    Search Similar: Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho 
    Search Authors: Andrea Malagon-Liceaga Martn Roberto Basile-Alvarez Carlos A. Fermn-Martnez Diana Laura Ramrez-Rivera Jernimo Perezalonso-Espinosa Juan Pablo Daz-Snchez Sara Berenice Garca-Gonzlez Karime Berenice Carrillo-Herrera Leslie Alitzel Cabrera-Quintana Neftali Eduardo Antonio-Villa Natalia Gomes Gonalves Carmen Garcia-Pea Omar Yaxmehen Bello-Chavolla, 
        AGING    BRAIN   

    Mne17-002

    Spatiotemporal Tau Accumulation and Its Clinical Impact on PSP: Longitudinal Florzolotau (18F) PET

    Quote: Conclusions This study provides in vivo evidence of the spatiotemporal progression of tau pathology in PSP. In the GP, tau accumulation emerges early and continues to rise with clinical deterioration. These findings support the utility of florzolotau PET for monitoring disease progression and as a biological outcome measure in tau-targeted therapeutic trials.
    Abstract: https://www.medrxiv.org/content/10.64898/2026.04.26.26350467v1
    Full Text: https://www.medrxiv.org/content/10.64898/2026.04.26.26350467v1.full-text
    Search Similar: Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho 
    Search Authors: Yoshikazu Chishiki Kenji Tagai Yuko Kataoka Ryoji Goto Kenta Osawa Asaka Oyama Hideki Matsumoto Masanori Ichihashi Yuki Momota Tetsuji Kamada Chie Seki Kiwamu Matsuoka Kosei Hirata Shin Kurose Sho Moriguchi Yuki Komatsu Hideo Kato Yasuharu Yamamoto Yoshikazu Nakano Shigeki Hirano Hitoshi Shinotoh Hitoshi Shimada Tokahiko Tokuda Kazunori Kawamura Ming-Rong Zhang Keisuke Takahata Makoto Higuchi Hironobu Endo, 
    Search Words:
    progressive supranuclear palsy (PSP) Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho 
        AGING    BRAIN    PSYCHOLOGY   

    Mne17-008

    BETA: Resting-state fMRI Biotypes for tDCS Efficacy in Anxiety Among Older Adults At Risk For Alzheimers Disease

    Quote: . Crucially, one cluster is resistant to frontal-lobe tDCS, whereas two clusters demonstrate significant anxiety reduction following stimulation. The responsive subtypes are defined by strengthened connectivity between the lateral occipital cortex-superior division (sLOC) and medial frontal cortex (MedFC), and between sLOC and the intracalcarine cortex (ICC).
    Abstract: https://www.medrxiv.org/content/10.64898/2026.04.24.26351493v1
    Full Text: https://www.medrxiv.org/content/10.64898/2026.04.24.26351493v1.full-text
    Search Similar: Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho 
    Search Authors: Skylar E. Stolte Junfu Cheng Chintan Acharya Lin Gu Andrew OShea Aprinda Indahlastari Adam J. Woods Ruogu Fang, 
        AGING    BRAIN    BRAINWAVE   

    Mne17-016

    Targeted memory reactivation during sleep modulates spindle and slow wave density, but not motor memory consolidation, in Parkinsons disease

    Quote: Results showed no effect of TMR on motor retention or dual-tasking, with no difference between the groups. However, the TMR intervention did increase slow-wave density and decreased spindle density in both groups, and slow-wave amplitude during the presentation of the auditory cues was positively associated with performance in HOA. In conclusion, TMR applied during a 2 hour nap did not enhance motor retention, but the changes in sleep physiological features could be linked to a possible underlying effect on memory processing that warrants further investigation.
    Abstract: https://www.medrxiv.org/content/10.64898/2026.04.22.26351552v1
    Full Text: https://www.medrxiv.org/content/10.64898/2026.04.22.26351552v1.full-text
    Search Similar: Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho 
    Search Authors: Letizia Micca Genevieve Albouy Bradley R King Alice Nieuwboer Wim Vandenberghe Pascal Borze Bertien Buyse Dries Testelman Judith Nicolas Moran Gilat, 
        AGING    METABOLISM   

    Mph17-004

    A Systems Pharmacology Model of Ageing Identifies Optimal Combination Therapies With Secondary Benefits on Weight Loss and Metabolic Health

    Quote: Results The model reproduced semaglutide efficacy and tolerability dynamics and supported distinct drug-class profiles across metabolic and ageing axes. Rapamycin showed minimal glycaemic effect but emerged as a dominant driver of repair-related ageing outcomes. Combination simulations predicted two distinct optima: one favouring metabolic improvement and one favouring ageing-related benefit.
    Abstract: https://www.medrxiv.org/content/10.64898/2026.04.22.26351392v1
    Full Text: https://www.medrxiv.org/content/10.64898/2026.04.22.26351392v1.full-text
    Search Similar: Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho 
    Search Authors: Igor Goryanin Bob Damms Irina Goryanin, 
        AGING    PSYCHOLOGY   

    Mpy17-010

    Psychomotor retardation and risk of Parkinsons disease in unipolar depression: a retrospective cohort study

    Quote: Results Among 6327 patients with depression, 2402 (38.0) had psychomotor retardation. The adjusted hazard ratio for development of Parkinsons in those with psychomotor retardation was 1.43 (95 CI 1.02 - 2.01, p 0.04). Secondary analyses demonstrated a significant difference in psychomotor retardation incidence at least 10 years before Parkinsons diagnosis.
    Abstract: https://www.medrxiv.org/content/10.64898/2026.04.26.26351763v1
    Full Text: https://www.medrxiv.org/content/10.64898/2026.04.26.26351763v1.full-text
    Search Similar: Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho 
    Search Authors: Hamilton Morrin James B. Badenoch Ella Burchill Aurore Fayosse Archana Singh-Manoux Paul Shotbolt Michael S. Zandi Anthony S. David Glyn Lewis Jonathan P. Rogers, 
        AGING   

    Sda171-010

    This One Change to Your Exercise Routine Could Add Years to Your Life

    Quote: Mixing up your workouts might be the real secret to a longer life. Long-term research tracking over 100,000 people for more than three decades suggests that doing a variety of physical activitiesrather than just more of the samecan ...
    Article: https://www.sciencedaily.com/releases/2026/04/260426012305.htm
    Search Similar: Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho 
        AGING    BRAIN   

    Sda171-016

    These 80-Year-Olds Have the Memory of 50-Year-Olds. Scientists Now Know Why Dementia Personalized Medicine Intelligence

    Quote: A rare group of adults over 80, known as SuperAgers, are rewriting what we thought was possible for the aging brain. With memory abilities comparable to people decades younger, their brains either resist or withstand the damage typically linked to Alzheimers disease. Decades of research reveal that their social lifestyles and unique brain biology may hold the key to preserving cognitive ...
    Article: https://www.sciencedaily.com/releases/2026/04/260423022006.htm
    Search Similar: Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho 
        AGING    COGNITION   

    Sda171-043

    Doing This Throughout Life May Cut Alzheimers Risk by 38 Dementia Social Psychology Alzheimers

    Quote: A lifetime of mental stimulationlike reading, writing, and learning new skillsmay help protect the brain as we age. People with the highest levels of cognitive enrichment had a much lower risk of Alzheimers and experienced symptoms years later than those with the lowest ...
    Article: https://www.sciencedaily.com/releases/2026/04/260414075648.htm
    Search Similar: Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho 

      Javilk's Research Links for Week 17
    Updated 05/02/2026-01:34:02 AM
    What interests you? What have you found? Tell me!
    Drop me a note to subscribe or submit something.