Research
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Scanned: 1397
Evaluated: 447
Selected: 78

 
    DIABETES    GENETICS   

Mdb17-002

PADI4 minor haplotype as risk factor for excessive NET formation and associated wound healing disorders in diabetes mellitus

Quote: Clinically, patients with DM carrying the minor haplotype had the highest rates of delayed wound healing and infections. Together, these results demonstrate that PADI4 genetic variation influences neutrophil behavior and clinical outcomes. PADI4 haplotyping may provide a clinically actionable biomarker to identify patients with DM at high risk for wound healing complications and guide early preventive strategies.
Abstract: https://www.medrxiv.org/content/10.1101/2024.11.28.24318124v2
Full Text: https://www.medrxiv.org/content/10.1101/2024.11.28.24318124v2.full-text
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Search Authors: Sabrina Ehnert Philipp Hemmann Christoph Ihle Caren Linnemann Jonas Mck Panagiota-Georgia Anastasiou Ralf Lobmann Gunnar Blumenstock Stefan Pscherer Andreas Fritsche Heiko Baumgartner Tina Histing Mika F. Rollmann Andreas K. Nussler, 
    DIABETES    OBESITY   

Mdb17-008

A systematic review and meta-analysis of the efficacy and safety of pharmacological treatments for obesity in adults: 2026 Update

Quote: . Semaglutide reduced major adverse cardiovascular events and all-cause mortality. In dedicated complication-specific trials, semaglutide and tirzepatide showed benefit on heart-failure-related outcomes; tirzepatide was associated with improved obstructive sleep apnoea syndrome and semaglutide with knee osteoarthritis pain remission. Tirzepatide and semaglutide were associated with improvements in metabolic dysfunction-associated steatohepatitis remission, and semaglutide with improvement in liver fibrosis. No OMMs were associated with an increased risk of serious adverse events. These updated results reinforce the need to individualize OMMs selection according to weight-loss efficacy, complication profile and safety.
Abstract: https://www.medrxiv.org/content/10.64898/2026.04.19.26351196v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.04.19.26351196v1.full-text
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Search Authors: Andreea Ciudin Jennifer L. Baker Andrej Belani Luca Busetto Dror Dicker ubomra Fbryov Gema Frhbeck Gijs H. Goossens Jason Gordon Matteo Monami Paolo Sbraccia Borja Martinez-Tellez Volkan Yumuk Barbara McGowan, 
    DIABETES   

Mdb17-010

Coregulated metabolite networks associated with global protein crotonylation are central pathophysiological processes in prediabetes and diabetes

Quote: Notably, short-chain organic acids, particularly crotonic acid, emerged as hubs of the diabetes-associated networks, accumulating progressively with disease severity. Reanalysis of extracellular vesicle proteomics from the same cohort showed that 16.5 of circulating proteins were crotonylated, with 47.6 correlated with crotonic acid and other hub metabolites, establishing a metabolome-crotonylome axis as a novel mechanism in diabetes development.
Abstract: https://www.medrxiv.org/content/10.64898/2026.04.19.26351178v2
Full Text: https://www.medrxiv.org/content/10.64898/2026.04.19.26351178v2.full-text
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Search Authors: Dhruv Dubey Tumpa Dutta Anna Casu Anton Iliuk Stephen J. Gardell Richard E. Pratley Yury O. Nunez Lopez, 
    DIABETES   

Mdb17-016

CGM glycemic persistence reflects OGTT dysglycemia

Abstract: https://www.medrxiv.org/content/10.64898/2026.04.22.26351476v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.04.22.26351476v1.full-text
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Search Authors: Ren Zhang, 
    AGING    DIABETES   

Mgr17-006

Prediabetes and glycemic transitions as determinants of frailty and functional decline in adults aged 50 years and older: A longitudinal analysis from five multinational aging cohorts

Quote: Interpretation Prediabetes is associated with increased risk of functional decline, frailty, and deficit accumulation in older adults, independent of progression to diabetes. Regression to normoglycemia was associated with higher risk of functional deterioration. These findings suggest that prediabetes reflects a state of metabolic vulnerability linked to biological aging rather than solely a precursor to diabetes and highlights a need to reframe its clinical significance in older populations.
Abstract: https://www.medrxiv.org/content/10.64898/2026.04.22.26351540v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.04.22.26351540v1.full-text
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Search Authors: Andrea Malagon-Liceaga Martn Roberto Basile-Alvarez Carlos A. Fermn-Martnez Diana Laura Ramrez-Rivera Jernimo Perezalonso-Espinosa Juan Pablo Daz-Snchez Sara Berenice Garca-Gonzlez Karime Berenice Carrillo-Herrera Leslie Alitzel Cabrera-Quintana Neftali Eduardo Antonio-Villa Natalia Gomes Gonalves Carmen Garcia-Pea Omar Yaxmehen Bello-Chavolla, 
    DIABETES    EYES   

Mop17-004

The Utility of Optical Coherence Tomography Angiography Biomarkers in Detecting Diabetic Retinopathy

Quote: Conclusion VD and PD from the superficial plexus are independently associated with DR and show superior discrimination versus conventional clinical factors alone, supporting OCT-A as an adjunct for earlier DR detection.
Abstract: https://www.medrxiv.org/content/10.64898/2026.04.22.26351527v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.04.22.26351527v1.full-text
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Search Authors: Kieran Kumanan Abolfazl Hassani Muhammad Husnain Elias Papaefstratiou Jose J. Estevez, 
    BRAIN    DIABETES    GUT    MICROBIOME    NUTRITION    PSYCHOLOGY   

Sda171-014

Harvard Scientists Link Gut Bacteria to Depression Through Hidden Inflammation Trigger Diabetes Diet and Weight Loss Diseases and Conditions

Quote: A gut bacterium may be quietly fueling depression through an unexpected chemical twist. Researchers found that when Morganella morganii interacts with a common pollutant, it produces a molecule that triggers inflammationsomething strongly linked to depression. This finding helps explain how gut microbes can influence brain health at a molecular ...
Article: https://www.sciencedaily.com/releases/2026/04/260425091216.htm
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    DIABETES    HEART   

Sda171-045

Two Common Drugs May Reverse Fatty Liver Disease, Study Finds Diabetes Diet and Weight Loss Cholesterol

Quote: Scientists have discovered that combining two existing drugs can dramatically reduce liver fat linked to a common and often silent disease. The treatment not only improved liver health in animal models but also showed potential to lower heart-related risks. Interestingly, using lower doses of both drugs together worked just as well as higher doses alone. While promising, the findings still need ...
Article: https://www.sciencedaily.com/releases/2026/04/260422003024.htm
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    DIABETES   

Sda172-009

Scientists Discover Enzyme That Could Supercharge Ozempic

Quote: Researchers have found an enzyme that can turn fragile drug molecules into durable ring shapes. This could help medications like Ozempic last longer and work more effectively. The process is simpler and more precise than traditional methods, even ...
Article: https://www.sciencedaily.com/releases/2026/04/260427050620.htm
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  Javilk's Research Links for Week 17
Updated 05/02/2026-01:34:02 AM
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