PRIME BRAIN CANCER DIABETES HEART NUTRITION
Aaa18-001	Health Benefits of Luteolin
	Quote:	Luteolin: A promising multifunctional natural flavonoid for human diseases Natural plant-based products are the original gifts of nature. It is noteworthy that LUT luteolin exhibits a variety of beneficial pharmacological properties and holds significant potential for clinical applications, particularly in antitumor, anti-convulsion, diabetes control, anti-inflammatory, neuroprotection, anti-oxidation, anti-cardiovascular, and other aspects. LUT is poised to emerge as one of the most promising candidates in the biomedical and pharmaceutical fields. -- Phytotherapy Research
	Article:	https://richardgoldberg.substack.com/p/health-benefits-of-luteolin
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DIABETES
Mep18-032	Early-life hallmarks of polygenic liability to adult internalizing-cardiometabolic multimorbidity
	Quote:	Orthogonal validation provided variable support: six demonstrated strong evidence of statistical colocalization; four replicated in an independent European proteomic dataset (deCODE, n 35,559); two replicated in an independent East Asian proteomic dataset (JCTF, n 1,384); and four were supported by polygenic-score analyses in the ancestrally diverse All of Us cohort (9,250 cases, 214,857 controls). These findings prioritize a high-confidence subset of plasma proteins, including LRRC25, PARK7, and LRRC37A2, for future mechanistic and translational investigation.
	Abstract:	https://www.medrxiv.org/content/10.64898/2026.05.01.26352146v1
	Full Text:	https://www.medrxiv.org/content/10.64898/2026.05.01.26352146v1.full-text
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	Search Authors:	Ruby S. M. Tsang Daniel Stow Ioanna K. Katzourou span classnlm-collab data-hwp-idcollab-1LINC Consortium Marianne B. M. van den Bree Golam M. Khandaker Nicholas J. Timpson,
DIABETES METABOLISM
Mep18-036	The Role of Type 2 Diabetes in Shaping Multimorbidity Progression: Evidence from the UK Biobank Cohort
	Quote:	Conclusion/interpretation Our study suggests that T2D is associated with accelerated development of subsequent multimorbidity, highlighting T2D as a critical contributor of chronic disease accumulation. The progression of disease accumulation is more pronounced in younger age groups, which suggests different underlying mechanisms of multimorbidity progression across age, warranting further investigation. The findings indicate the need for early intervention among younger people with T2D to slow multimorbidity progression.
	Abstract:	https://www.medrxiv.org/content/10.64898/2026.05.01.26352200v1
	Full Text:	https://www.medrxiv.org/content/10.64898/2026.05.01.26352200v1.full-text
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	Search Authors:	Jie Zhang Lasse Bjerg Susanne Boel Graversen Henrik Stvring Christina C. Dahm Bendix Carstensen Daniel Witte,
AGING COGNITION DIABETES HEART
Mge18-026	Evidence of Epistatic Interactive Effects of HK1 and GCK Genes on Circulating Hemoglobin A1c Levels
	Quote:	Background Hemoglobin A1c (HbA1c), an important diagnostic biomarker for type 2 diabetes (T2D), is also associated with aging, cognitive performance, and mortality. .... Conclusion The present study revealed that HK1 and GCK interact to contribute to regulating levels of HbA1c and are likely to be involved in molecular mechanisms underlying healthy aging processes.
	Abstract:	https://www.medrxiv.org/content/10.64898/2026.05.01.26352221v1
	Full Text:	https://www.medrxiv.org/content/10.64898/2026.05.01.26352221v1.full-text
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	Search Authors:	Lihua Wang Joseph H. Lee Bharat Thyagarajan Anatoliy I. Yashin E. Warwick Daw Thomas T. Perls Kaare Christensen Joseph M. Zmuda Michael A. Province Ping An,

Javilk's Research Links for Week 18
Updated 05/09/2026-12:26:41 AM
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Aaa18-001

Health Benefits of Luteolin

Mep18-032

Early-life hallmarks of polygenic liability to adult internalizing-cardiometabolic multimorbidity

Mep18-036

The Role of Type 2 Diabetes in Shaping Multimorbidity Progression: Evidence from the UK Biobank Cohort

Mge18-026

Evidence of Epistatic Interactive Effects of HK1 and GCK Genes on Circulating Hemoglobin A1c Levels