AGING DIABETES HERBS NUTRITION
Aab20-002	45 Herbal leaves
	Quote:	Olive Leav extract reduces inflammation. Mulberry leaf, blood sugar pre-diabetic help. Lemon Balm Leaf, mitochondria support and cortisol reduction. Maringa leaf, muscle support. Bay leaf,. synergistic effect on jpoints, blood sugar, .
	Article:	http://youtube.com/watch?v=nNNj5wG4yYM
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AGING CANCER DIABETES HEART METABOLISM
Aab20-006	What Are Sirtuins and How Do They Affect Aging and Longevity?
	Quote:	Sirtuins are NAD -dependent enzymes that regulate metabolism, oxidative stress, mitochondrial function, and genomic stability to influence aging and healthspan. Their tissue-specific activities have made them promising but complex therapeutic targets for metabolic, cardiovascular, neurodegenerative, and age-related diseases.... Sirtuins facilitate adaptive metabolic responses during periods of fasting, caloric restriction, and exercise. For example, SIRT1 acts as an autophagy modulator through the deacetylation of major transcription factors like peroxisome-activated receptor coactivator 1-#945; (PGC-1#945;) and forkhead box O3 (FoxO3) proteins, thereby enhancing fatty acid oxidation and glucose production in the liver. In skeletal muscles, SIRT1 has been associated with mitochondrial biogenesis and improved insulin sensitivity to support systemic metabolic health. Skeletal-muscle sirtuins also regulate glucose uptake, fatty acid oxidation, mitochondrial dynamics, autophagy, myogenesis, fiber-type switching, regeneration, and exercise adaptation, although these effects remain isoform- and context-dependent.
	Article:	https://www.news-medical.net/health/What-Are-Sirtuins-and-How-Do-They-Affect-Aging-and-Longevity.aspx
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PRIME AGING IMMUNE NUTRITION
Aac20-000	Scientists boosted one protein and aging mice became stronger and healthier
	Quote:	"These age-related changes, known as immunosenescence, lead to a decline in immune resilience and an increased susceptibility to age-related chronic inflammatory diseases," Kirkwood explains. Kirkwood recently led a long running study focused on reducing frailty in older mice. The research centered on tristetraprolin (TTP), an RNA binding protein that helps control inflammation by breaking down inflammatory signals before they can build up.
	Article:	https://www.sciencedaily.com/releases/2026/05/260518041436.htm
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AGING
Mre20-030	Wearable Vibration Neuromodulation for Freezing of Gait: A Randomised Controlled Trial
	Quote:	Conclusions Cadence-linked, localised vibration neuromodulation plus motor-learning training was feasible and was associated with clinically meaningful within-intervention group reductions in FOG.
	Comment:	FOG: Freezing of Gate, a Parkinsons Disease issue.
	Abstract:	https://www.medrxiv.org/content/10.64898/2026.05.14.26352486v1
	Full Text:	https://www.medrxiv.org/content/10.64898/2026.05.14.26352486v1.full-text
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	Search Authors:	Rajesh Benny Amey Desai Anil Venkitachalam Vicky Thakkar Ria Rajput Samit Chakrabarty,
AGING NUTRITION
Sda201-007	Eating Grapes Daily Could Unlock Powerful Skin Protection
	Quote:	Scientists discovered that eating grapes can actually change how your skin behaves at the genetic level. After just two weeks of daily grape consumption, volunteers showed signs of improved skin protection and reduced oxidative stress from UV ...
	Article:	https://www.sciencedaily.com/releases/2026/05/260517211427.htm
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AGING
Sda201-013	Scientists Reverse Alzheimers in Mice With Breakthrough
	Quote:	A new nanotechnology treatment reversed Alzheimers symptoms in mice by restoring the brains natural cleanup system. The specially engineered nanoparticles helped clear toxic amyloid proteins from the brain and repair the blood-brain barrier, which normally protects and regulates the brains environment. In one striking experiment, elderly mice treated with the therapy later behaved like ...
	Article:	https://www.sciencedaily.com/releases/2026/05/260517030326.htm
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AGING BRAIN
Sda201-015	Scientists Reversed Memory Loss by Recharging the Brains Tiny Engines
	Quote:	Researchers have shown for the first time that malfunctioning mitochondria the cells energy generators may directly cause cognitive decline in neurodegenerative diseases. By creating a new tool that temporarily boosts mitochondrial activity in the brain, scientists restored memory performance in mouse models of dementia. The discovery hints that energy failure inside neurons could ...
	Article:	https://www.sciencedaily.com/releases/2026/05/260515234803.htm
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AGING
Sda201-026	A Grad Students Wild Idea Sparks a Major Aging Breakthrough
	Quote:	A casual conversation between graduate students helped spark a breakthrough in aging research at Mayo Clinic. Researchers discovered that tiny synthetic DNA molecules called aptamers can selectively attach to senescent zombie cells, which are ...
	Article:	https://www.sciencedaily.com/releases/2026/05/260515001733.htm
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AGING GUT
Sda201-045	Scientists Discover Tiny Gut Particles That May Drive Aging and Chronic Disease
	Quote:	A new study suggests microscopic particles from the gut may actively drive inflammation and chronic diseases associated with aging. Remarkably, gut particles from young animals appeared to counter some aging-related damage in older animals, hinting at new possibilities for future ...
	Article:	https://www.sciencedaily.com/releases/2026/05/260515233322.htm
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AGING
Sda204-013	Scientists Discover Why Alzheimers Risk Hits Women So Much Harder
	Article:	https://www.sciencedaily.com/releases/2026/05/260519224312.htm
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AGING BRAIN
Sda204-014	Scientists Found a Hidden Alzheimers Trigger and Shut It Down
	Quote:	Hande Karahan, PhD, assistant research professor of medical and molecular genetics, said deleting IDOL in neurons not only lowered plaque levels but also reduced levels of apolipoprotein E (APOE), a protein strongly associated with Alzheimers disease. One form of the protein, APOE4, is considered the greatest genetic risk factor for late onset Alzheimers disease. APOE is also important for regulating lipid metabolism in the brain. Researchers also found increased levels of receptors involved in regulating APOE and amyloid plaques after the enzyme was removed from neurons. These receptors are important for maintaining healthy communication between neurons and supporting lipid metabolism.
	Article:	https://www.sciencedaily.com/releases/2026/05/260519224334.htm
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PRIME AGING COGNITION
Sda204-031	Your Um and Pauses Could Reveal Early Dementia Risk
	Quote:	The little pauses, ums, and moments when you struggle to find the right word may reveal far more about your brain than anyone realized.
	Article:	https://www.sciencedaily.com/releases/2026/05/260512202333.htm
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AGING CANCER
Sda204-034	New Drugs Could Wipe Out the Zombie Cells Linked to Cancer and Aging
	Quote:	Researchers found a new way to kill harmful zombie cells that linger after chemotherapy and help cancers become more aggressive. These senescent cells survive by relying on a protective protein called GPX4
	Article:	https://www.sciencedaily.com/releases/2026/05/260509210646.htm
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AGING
Sda204-035	Scientists Make Old Blood Stem Cells Young Again in Major Anti-aging Breakthrough
	Quote:	Scientists at the Icahn School of Medicine at Mount Sinai have successfully reversed aging in blood-forming stem cells in mice by repairing defects in structures known as lysosomes. The findings, published in Cell Stem Cell, point to lysosomal dysfunction and overactivity as major causes of stem cell aging and show that restoring proper lysosomal activity can rejuvenate old stem cells and improve their ability to regenerate blood and immune cells.
	Article:	https://www.sciencedaily.com/releases/2026/05/260511213204.htm
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AGING
Sda204-038	Breakthrough Drug Reverses Aging in Skin and Dramatically Speeds Healing
	Article:	https://www.sciencedaily.com/releases/2026/05/260519003215.htm
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AGING
Sda204-086	Scientists Successfully Transfer Longevity Gene and Extend Lifespan
	Quote:	Scientists at the University of Rochester pulled off a remarkable experiment: they transferred a longevity-related gene from the famously long-lived naked mole rat into mice, and the mice ended up healthier and lived longer. The special gene boosts production of a substance called high molecular weight hyaluronic acid, which appears to protect against cancer, reduce inflammation, and support ...
	Article:	https://www.sciencedaily.com/releases/2026/05/260510030948.htm
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PRIME AGING IMMUNE PAIN
Sda205-006	Scientists Discover Simple Way to Relieve Arthritis Pain Without Pills or Surgery
	Quote:	In the yearlong randomized controlled trial, people with knee osteoarthritis were trained to make a small, personalized change in the angle of their foot while walking. The result was striking. Participants who received the real gait retraining reported pain relief comparable to medication, and MRI scans suggested they had less knee cartilage deterioration than people in the placebo group.... But there is a key challenge: the best walking adjustment is not the same for everyone. Some people reduce knee loading by turning their toes slightly inward. Others benefit more from pointing them outward. For some, the wrong change can fail to help or even increase stress on the painful part of the knee.
	Comment:	Outward is what my podiatrist favored many decades ago. Dr. Cathcart suggested this is more prevalent when the body is being stressed by lack of adequate antioxidants, often caused by either poor diet or hidden allergies. But he too, spoke of walking right. My knees healed two weeks after I moved out of a damp, ocean side environment.
	Article:	https://www.sciencedaily.com/releases/2026/05/260522031135.htm
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AGING PAIN
Sda205-009	Popular Weight Loss Drugs Like Wegovy May Also Target Arthritis Inflammation
	Quote:	Researchers have discovered that the GLP-1 hormone targeted by drugs like Wegovy is present in very low amounts inside the joints of arthritis patients. That finding suggests high-dose GLP-1 medications could potentially reach the joints and influence inflammation directly, not just help through weight loss. Scientists say this could open the door to a completely new approach to arthritis treatment. ,,, The researchers caution that patients should not expect GLP-1 drugs to become arthritis treatments anytime soon. Much more research is needed before doctors can determine whether these medications can actually reduce inflammation or relieve symptoms inside the joints.
	Article:	https://www.sciencedaily.com/releases/2026/05/260521072408.htm
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PRIME AGING
Sda205-010	Zombie cells arent always bad and that could transform anti-aging medicine
	Quote:	Aging research is entering a new phase as scientists rethink one of the bodys most mysterious cell types: senescent cells, often nicknamed "zombie cells." While these aging cells have long been viewed as harmful drivers of inflammation and disease, new findings suggest the story is far more complicated. In some cases, senescent cells may actually help protect and repair the body.
	Article:	https://www.sciencedaily.com/releases/2026/05/260521072402.htm
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AGING CANCER
Sda205-037	Scientists Discover a Two-Stage Aging Process That May Cause Cancer and Arthritis
	Quote:	A new theory suggests many age-related diseases may actually start decades before symptoms appear. Researchers say early-life damage from infections, injuries, or genetic mutations can remain hidden until aging weakens the body;s ability to keep it under control.
	Article:	https://www.sciencedaily.com/releases/2026/05/260521072420.htm
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Javilk's Research Links for Week 20
Updated 05/22/2026-09:49:18 PM
What interests you? What have you found? Tell me!
Drop me a note to subscribe or submit something.

Aab20-002

45 Herbal leaves

Aab20-006

What Are Sirtuins and How Do They Affect Aging and Longevity?

Aac20-000

Scientists boosted one protein and aging mice became stronger and healthier

Mre20-030

Wearable Vibration Neuromodulation for Freezing of Gait: A Randomised Controlled Trial

Sda201-007

Eating Grapes Daily Could Unlock Powerful Skin Protection

Sda201-013

Scientists Reverse Alzheimers in Mice With Breakthrough

Sda201-015

Scientists Reversed Memory Loss by Recharging the Brains Tiny Engines

Sda201-026

A Grad Students Wild Idea Sparks a Major Aging Breakthrough

Sda201-045

Scientists Discover Tiny Gut Particles That May Drive Aging and Chronic Disease

Sda204-013

Scientists Discover Why Alzheimers Risk Hits Women So Much Harder

Sda204-014

Scientists Found a Hidden Alzheimers Trigger and Shut It Down

Sda204-031

Your Um and Pauses Could Reveal Early Dementia Risk

Sda204-034

New Drugs Could Wipe Out the Zombie Cells Linked to Cancer and Aging

Sda204-035

Scientists Make Old Blood Stem Cells Young Again in Major Anti-aging Breakthrough

Sda204-038

Breakthrough Drug Reverses Aging in Skin and Dramatically Speeds Healing

Sda204-086

Scientists Successfully Transfer Longevity Gene and Extend Lifespan

Sda205-006

Scientists Discover Simple Way to Relieve Arthritis Pain Without Pills or Surgery

Sda205-009

Popular Weight Loss Drugs Like Wegovy May Also Target Arthritis Inflammation

Sda205-010

Zombie cells arent always bad and that could transform anti-aging medicine

Sda205-037

Scientists Discover a Two-Stage Aging Process That May Cause Cancer and Arthritis