Research
Topics:
INDEX
MCS 3
PRIME 37
aging 18
brain 25
brainwave 4
cancer 20
climate 1
cognition 12
covid-19 3
crime 4
culture 4
dental 7
diabetes 7
diagnostics 4
disease 2
drugs 5
economy 2
exercise 2
eyes 1
genetics 7
gut 2
heart 11
immune 4
kidneys 2
language 3
lungs 2
metabolism 4
microbiome 4
misc 1
music 1
nutrition 16
obesity 2
pain 6
physical 1
politics 5
pollution 2
practice 2
privacy 2
psychology 12
reproduction 4
rights 1
sleep 5
soc-media
stress 1
tech 3
unk
vaccine 2
virus 2
war-confl
 
Scanned: 4202
Evaluated: 821
Selected: 129

 
    PRIME    METABOLISM    MICROBIOME    NUTRITION   

Aaa25-001

The Health Benefits of Papaya

Quote: In traditional medicine, different parts of C. papaya L. (leaves, stem, roots, fruits and seeds) are utilized to treat various diseases... In vitro and in vivo studies on papaya showed various pharmacological activities such as anti-cancer, anti-inflammatory, antimicrobial, antidiarrheal, wound healing, larvicidal, anxiolytic, neuroprotective, hepatoprotective, anti-diabetic, anti-hyperlipidemic, anti-obesity, antiulcer, antithrombocyt openic, anthelminthic and contraceptive activities. These pharmacological activities may be due to numerous bioactive compounds in different parts of papaya.Pharmacological Research Jun 2023
Article: https://richardgoldberg.substack.com/p/the-health-benefits-of-papaya
Search Similar: Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho 
    PRIME    AGING    NUTRITION   

Aaa25-003

Scientists say most people need more protein than current guidelines suggest

Quote: A new review suggests that doing more exercise and eating more protein than current minimum recommendations may help people stay stronger, sharper, and more independent as they age. The goal isnt building a beach bodyits extending healthspan and maintaining the ability to fully enjoy life for decades longer.
Article: http://www.sciencedaily.com/releases/2026/06/260622091429.htm
Search Similar: Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho 
    PRIME    MICROBIOME    POLLUTION   

Aaa25-006

Fog is Alive, a floating ecosystem

Quote: "When you take all of the droplets together, the concentration of bacteria is the same as in the ocean," says Garcia-Pichel, also a Regents Professor in the ASU School of Life Sciences. A thimbles worth of fog water has some 10 million bacteria. One group of bacteria stood out: methylobacteria. Samples of dry air collected before fog events contained less of these bacteria than samples collected immediately after. That suggests fog briefly boosts their numbers. Methylobacteria eat simple carbon compounds, which include nasty chemicals like formaldehyde. Formaldehyde is a common pollutant that adds to ozone smog and harms human health.
Comment: I thought that fog having life was obvious to anyone with mold allergies.
Article: https://news.asu.edu/20260514-environment-and-sustainability-fog-alive-researchers-discover-bacteria-fog-droplets-clear
Search Similar: Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho 
    PRIME    DISEASE   

Aab25-004

Disrupted Mitochondrial Copper Homeostasis Promotes Ferroptotic Stress, Senescence and MASLD Progressionb

Quote: Conclusions Mitochondrial copper deficiency is a mechanistically actionable driver of MASLD that promotes bioenergetic failure, ferroptosis, senescence and fibroinflammatory damage in the liver and other organs. Targeting copper-centered mitochondrial regulation represents a novel biomarker and therapeutic strategy for MASLD and its systemic complications.
Article: https://www.biorxiv.org/content/10.64898/2026.06.15.731916v1
Search Similar: Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho 
Search Words:
metabolic dysfunction associated steatotic liver disease (MASLD) Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho 
    PRIME    POLITICS    RIGHTS    SOC-MEDIA   

Aac25-000

Newsguard Wants to Empower AI Censorship, Rates Chinese Propaganda as More Reliable than Conservative Media

Quote: Breitbart News reported that GDI claimed that the top ten outlets at most risk of spreading disinformation included center-right outlets such as the Federalist and the New York Post, while those labeled as the least likely to spread disinformation included HuffPost and ProPublica. Newsguard reportedly encouraged AI companies to use its data during the "supervised learning" process, a technique that influences how AI models analyze information and coordinates AI outputs with developer preferences.
Comment: This is not just information warfare against opur citizens, it is also economic warfare against those who represent the very values which built this nation.
Article: https://www.breitbart.com/politics/2026/06/22/newsguard-wants-to-empower-ai-censorship-rates-chinese-propaganda-as-more-reliable-than-conservative-media/
Search Similar: Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho 
Search Words:
infocracy Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho 
hydraulic empire Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho 
    PRIME    CULTURE   

Aac25-001

Europeans Visiting U.S. for World Cup Fall in Love with America: The Most Wonderful People in the World

Quote: Europeans visiting the United States for the 2026 World Cup have found themselves pleasantly surprised by small-town America, Buc-ees, Target, large portion sizes, and unlimited soda refills, according to footage circulating on social media. "We owe America a huge apology, because America is nothing like the media tells us," one World Cup fan said. "Everyone is so friendly Ive honestly had the best time."
Article: https://www.breitbart.com/sports/2026/06/22/europeans-visiting-u-s-for-world-cup-fall-in-love-with-america-the-most-wonderful-people-in-the-world/
Search Similar: Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho 
    PRIME    CULTURE    VIRUS   

Aac25-002

Ebola Spreads in Congo Refugee Camps, Cases Top 1,000

Quote: The families of many of the dead refused to cooperate with Ebola protocols for burial, a sadly familiar trend in the Congo that has helped Ebola spread by bringing unprotected people into contact with infected bodies. "Our team tried to persuade people to accept doctors to inspect the bodies. They completely refused," said Justin Zanamuzi, director of the Catholic aid group Caritas.
Comment: Sr. Cathcart said the early survivors of Ebola were taking vitamin C. Vitamin C is a potent anti-viral, helps rebuild the connective tissue Ebola destroys, etc.
Article: https://www.breitbart.com/africa/2026/06/22/ebola-spreads-in-congo-refugee-camps-cases-top-1000/
Search Similar: Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho 
    PRIME    CRIME   

Aac25-003

FBI Busts Multimillion Dollar Fraud Schemes Across the Country

Quote: FBI Cleveland, for instance, disrupted a Chinese phishing platform "linked to the theft of millions of credit card numbers and nearly 1.9 billion dollars in losses worldwide," Patel revealed. As a result of the efforts of the FBI in Charlotte, two individuals were convicted for operating a business email compromise scheme that stole 25 million from U.S. companies. "Thanks to FBI Boston, our Cyber Division, and international partners, we helped dismantle a VPN service used by ransomware groups around the world,
Article: https://www.breitbart.com/politics/2026/06/22/fbi-busts-multimillion-dollar-fraud-schemes-across-the-country/
Search Similar: Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho 
    PRIME    MISC   

Bbc25-002

Discovery of CDK4-selective molecular glue degraders by high-throughput proteomics

Quote: Molecular glue degraders (MGDs) are proximity-inducing molecules that promote the destruction of disease-causing proteins by stabilizing novel interfaces between E3 ubiquitin ligases and target proteins....

This workflow led to the discovery of NE26394, a first-in-class MGD that selectively eliminates cyclin-dependent kinase 4 (CDK4), a critical oncogenic driver of cell cycle progression.

Article: https://www.biorxiv.org/content/10.64898/2026.06.19.733443v1
Search Similar: Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho 
Search Authors: Patrick R.A. Zanon Bachuki Shashikadze Denise Winkler Ines Scheller Anastasia Bednarz Denis Bartoschek Sophie Machata Tobias Graef Uli Ohmayer Bjoern Schwalb Martin Steger Henrik Daub, 
    PRIME    GENETICS    PRIVACY   

Bmo25-005

Temporal persistence of vertebrate airborne environmental DNA in a natural open-air setting

Quote: Airborne environmental DNA (eDNA) is a promising tool for detecting a wide range of terrestrial taxa, including threatened and invasive species, from trace genetic material shed into the air.
Comment: Animals, and humans exhail
Article: https://www.biorxiv.org/content/10.64898/2026.04.20.719767v2
Search Similar: Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho 
Search Authors: Gracie C Kroos Kristen Fernandes Philip Seddon Travis Ashcroft Neil J Gemmell, 
    PRIME    DIABETES   

Mbr25-002

Diabetes is associated with increased nocturnal respiratory rate

Quote: Conclusions Clinically stable outpatients with elevated NRR have an increased prevalence of DM. Additional studies are needed to investigate whether the mechanism is autonomic neuropathy and whether monitoring NRR can detect early complications of DM.
Abstract: https://www.medrxiv.org/content/10.64898/2026.06.16.26355548v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.06.16.26355548v1.full-text
Search Similar: Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho 
Search Authors: Keshav S. Gupta Raimon Padrs-Valls Nicholas Harrington David Torres Barba Kevin R. King, 
    PRIME    LUNGS    MUSIC   

Mbr25-010

A Pilot Study of the EMPOWER Music-based Intervention to Reduce Pulmonary Air Trapping in COPD

Quote: Main Results All five adult participants with COPD who enrolled completed the study and reported strong interest in continuing with a similar program. Additionally, we observed trends toward improvement in qCT-measured fSAD, six-minute walk distance, and patient-reported symptoms on the COPD Assessment Test.
Abstract: https://www.medrxiv.org/content/10.64898/2026.05.26.26350616v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.05.26.26350616v1.full-text
Search Similar: Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho 
Search Authors: Jasmine M. Taylor Jiwoong Choi Asma Abdolijomoor Melissa C. Brunkan Amy L. Wilson Mario Castro Nancy H. Stewart Deanna Hanson-Abromeit Rebecca J. Lepping, 
    PRIME    NUTRITION   

Mbr25-011

The CRAC channel inhibitor Auxora interrupts inflammatory circuits between alveolar macrophages and T cells in patients with viral pneumonia

Quote: we show that Auxora directly targets T cells to inhibit the transcription of CCL8 and PDGFA in monocyte-derived macrophages, supporting a mechanism for its effects and a potential intermediate biomarker of efficacy.
Comment: Dr. Cathcart cured a number of anorexia cases using zinc suppliments in just a few days of treatment. He said anorexia appears to be a symptom of zinc deficiency.
Abstract: https://www.medrxiv.org/content/10.64898/2026.05.27.26354034v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.05.27.26354034v1.full-text
Search Similar: Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho 
Search Authors: S. Marina Casalino Matsuda Vijeeth Guggilla Catherine A. Gao Kaitlyn E. Demeulenaere Luisa Cusick Samuel W. Fenske Zhan Yu Ziyan Lu Suchitra Swaminathan Rogan A. Grant Maxwell J. Schleck Murali Prakriya Sudarshan Hebbar Kenneth Stauderman Helen K. Donnelly Chiagozie I. Pickens Luisa Morales-Nebreda span classnlm-collab data-hwp-idcollab-1The NU SCRIPT Study Investigators Richard G. Wunderink Alexander V. Misharin Benjamin D. Singer G.R. Scott Budinger, 
    PRIME    AGING    CANCER   

Mca25-008

A Poisson Process Life Expectancy framework for optimising patient lifetime during chemotherapy

Quote: Mortality is modelled as a Poisson processes, a framework that enables the patients expected lifetime to be computed. The model and objective are biologically interpretable and can in principle be calibrated using clinical data. We demonstrate the approach for a logistic tumour growth model, illustrating the trade-offs between tumour control and toxicity.
Abstract: https://www.medrxiv.org/content/10.64898/2026.06.15.26354436v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.06.15.26354436v1.full-text
Search Similar: Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho 
Search Authors: Byron D. E. Tzamarias Nigel J. Burroughs, 
    PRIME   

Mca25-009

AI-assisted continuous-time modelling of metastatic breast cancer reveals subtype-specific spatiotemporal organ interactions

Quote: Together, these findings define a clinically relevant spatiotemporal architecture of metastatic progression in breast cancer. This framework enables refined mechanism-informed risk stratification and provides a data-driven rationale for targeted and risk-adapted rather than symptom-triggered surveillance strategies.
Abstract: https://www.medrxiv.org/content/10.64898/2026.06.15.26355684v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.06.15.26355684v1.full-text
Search Similar: Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho 
Search Authors: Marc Vaisband Gabriel Rinnerthaler Simon Peter Gampenrieder Nadine Binder Christian Fridolin Singer Thamer Sliwa Florian Roitner Christopher Hager Petra Pichler Simon Udovica Rupert Bartsch Sonja Heibl Daniel Egle Clemens A. Schmitt August Felix Zabernigg Margit Sandholzer Johannes Andel Renate Pusch Richard Greil Jan Hasenauer, 
    MCS    PRIME    POLLUTION   

Mep25-013

AI-Assisted Causal Inference and Mediation Analyses of Environmental and Psychosocial Determinants of Subjective Cognitive Difficulties in the All of Us Research Program

Quote: These findings suggest that short-term environmental perturbations may have limited associations with cognitive outcomes after accounting for within-location variation, whereas psychosocial factors appear to be more consistently associated with subjective cognitive burden.
Comment: they have no idea. but also, the locality they refer to is related to people seeking out othes with similar issues.
Abstract: https://www.medrxiv.org/content/10.64898/2026.06.18.26355982v2
Full Text: https://www.medrxiv.org/content/10.64898/2026.06.18.26355982v2.full-text
Search Similar: Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho 
Search Authors: Shuangge Ma Cong Cao, 
    PRIME    AGING    BRAIN   

Mge25-003

A TAD-informed aging-brain xQTL atlas of multi-modal and cell-type-resolved regulatory variation

Quote: Understanding the regulatory consequences of genetic variation in the aging human brain requires molecular maps that span brain regions, cell types and regulatory modalities. We present the Alzheimers Disease Sequencing Project Functional Genomics (FunGen-AD) xQTL Atlas, a harmonized resource of molecular quantitative trait loci from four postmortem brain studies, ROSMAP, MSBB, Knight-ADRC and MiGA. The atlas integrates histone acetylation, DNA methylation, gene expression, splicing and protein abundance QTLs across 14 brain regions, 7 major cell types and 17,566 samples, with standardized association, significance-filtered and fine-mapping outputs.
Abstract: https://www.medrxiv.org/content/10.64898/2026.05.21.26353713v2
Full Text: https://www.medrxiv.org/content/10.64898/2026.05.21.26353713v2.full-text
Search Similar: Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho 
Search Authors: Jeffrey Cifello Ru Feng Francis P. Grenn Luke Carter Anjing Liu Hao Sun Ruixi Li Jenny Anak Empawi Emily Greenfest-Allen Zivadin Katanic Otto Valladares Amanda B. Kuzma Heather White Lindsay A. Farrer Alison M. Goate Towfique Raj Minghui Wang Carlos Cruchaga Li-San Wang Hans Klein Han Chen span classnlm-collab data-hwp-idcollab-1ADSP Functional Genomics Consortium Philip L. De Jager Edoardo Marcora Julia TCW Xiaoling Zhang Pavel P. Kuksa Gao Wang Yuk Yee Leung, 
    PRIME    DIABETES    VACCINE   

Mim25-011

PRV-101 Coxsackievirus B vaccine elicits protective T follicular helper immunity while avoiding cytotoxic T-cell responses in humans: implications for type 1 diabetes prevention

Quote: We conclude that PRV-101 elicits a CVB-protective immune profile, dominated by Tfh responses supporting durable humoral immunity and devoid of potentially diabetogenic cytotoxic T-cell responses. This profile invites further investigations in vaccine trials for type 1 diabetes prevention.
Abstract: https://www.medrxiv.org/content/10.64898/2026.05.19.26352997v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.05.19.26352997v1.full-text
Search Similar: Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho 
Search Authors: Federica Vecchio Margot Petit Orlando Burgos-Morales Jutta E. Laiho Mika Scheinin Mikael Knip Francisco Len Miguel Sanjuan Heikki Hyty Sylvaine You Roberto Mallone, 
    PRIME    CRIME   

Mmx25-010

Drug company payments to Australian healthcare professionals

Abstract: https://www.medrxiv.org/content/10.1101/2025.09.10.25335461v1
Full Text: https://www.medrxiv.org/content/10.1101/2025.09.10.25335461v1.full-text
Search Similar: Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho 
Search Authors: Malcolm Forbes Kane Harvey Spencer Schien Ashleigh Hooimeyer Adrian Pokorny, 
    PRIME    AGING    BRAIN    BRAINWAVE   

Mne25-003

Entrainment of cortical gamma oscillations predicts improved bradykinesia and dyskinesia in Parkinsons disease

Quote: Background Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is hypothesized to improve motor symptoms in Parkinsons disease (PD) by suppressing pathologically elevated beta activity and promoting "prokinetic" gamma activity in the cortico-basal ganglia-thalamo-cortical loop. Advances in bidirectional DBS devices have revealed that stimulation can modify gamma oscillations via subharmonic entrainment
Abstract: https://www.medrxiv.org/content/10.64898/2026.06.10.26354720v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.06.10.26354720v1.full-text
Search Similar: Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho 
Search Authors: Maria Shcherbakova Stephanie Cernera Amelia G. Hahn Simon Little Philip A. Starr, 
    PRIME    BRAIN   

Mne25-009

Targeted Proteomic Profiling of Nasal Fluid from the Brain-Nose Interface

Quote: Numerous disease-relevant proteins were observed in nasal fluid, including brain-derived tau species, phosphorylated tau, #945;-synuclein, axonal and synaptic markers, and glial-microglial mediators. To our knowledge, this is the first neurology-focused characterization of the nasal proteome from the vicinity of brain-nose interface using targeted multiplex platforms and the first to profile matched nasal fluid, CSF, and plasma, supporting nasal fluid from brain-nose interface as an additional source for biomarker development.
Abstract: https://www.medrxiv.org/content/10.64898/2026.06.16.26355519v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.06.16.26355519v1.full-text
Search Similar: Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho 
Search Authors: Mohammad Bashiri Maria Babu Gunter Weiss Stefan Kotschote Richard Metzler Hilary Wunderlich Agnese Petrera Elena De Domenico Heidi Theis Katrin Lehmann Frederik Heinrich Mir-Farzin Mashreghi Marion San Nicol Mareike Albert Sabine Mertzig, 
    PRIME    AGING    BRAIN    SLEEP   

Mne25-011

Preserved Medial Temporal Lobe Flexibility Predicts Memory Generalization Only in the Context of Good Sleep Quality among Older African Americans

Abstract: https://www.medrxiv.org/content/10.64898/2026.06.15.26355704v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.06.15.26355704v1.full-text
Search Similar: Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho 
Search Authors: Payton White Miray Budak Soodeh Moallemian Bernadette A. Fausto Mark A. Gluck, 
    PRIME    BRAIN    PAIN   

Mne25-016

Anterior-superior hypothalamic enlargement as specific marker in episodic migraine: converging evidence from an independent discovery-replication design

Quote: Conclusions These findings provide evidence for subunit-specific hypothalamic structural alterations in migraine localized in the left anterior hypothalamic subunit. The stability of these differences over time and their absence in other chronic pain conditions suggest a migraine-specific structural organisation of hypothalamic circuitry.
Abstract: https://www.medrxiv.org/content/10.64898/2026.06.12.26355501v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.06.12.26355501v1.full-text
Search Similar: Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho 
Search Authors: Dan Liu Shengkun Peng Longlin Yin Xueyang Wen Bin Huang Keith Maurice Kendrick Benjamin Becker Dezhong Yao Stefania Ferraro, 
    PRIME    BRAIN    BRAINWAVE   

Mne25-017

Between Patterns and Predictions: Interpretable Latent EEG Representations for Clinical Insights

Abstract: https://www.medrxiv.org/content/10.64898/2026.06.12.26355536v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.06.12.26355536v1.full-text
Search Similar: Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho 
Search Authors: Laura Krumm Robert Terziev Dominik D. Kranz M. Brandon Westover Christian Meisel, 
    PRIME    PSYCHOLOGY   

Moc25-011

Living Environments and Mental Health: the environMAP database

Quote: We present environMAP, a harmonised set of analysis-ready environmental exposure layers derived from open, global sources. environMAP spans the built environment, green and blue spaces, light exposure (solar radiation and night-time light), terrain, weather and extremes, and air pollution.
Abstract: https://www.medrxiv.org/content/10.64898/2026.05.15.26353275v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.05.15.26353275v1.full-text
Search Similar: Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho 
Search Authors: Paul Renner Elli Polemiti Marcel Jentsch Jamie R. Banks Dennis Cleff Sebastian Siehl Marco Dallavalle Tristram Lett Christoph Buck Stefanie Castell Jonas Frost Hans Grabe Thomas Keil Volker Harth Robyn Kettlitz Lilian Krist Michael Leitzmann Rafael Mikolajczyk Nour Naaouf Nadia Obi Annette Peters Alexandra Schneider Kathrin Wolf Frauke Nees Sven Olaf Twardziok Andr Marquand Sren Hese Kerstin Schepanski Gunter Schumann span classnlm-collab data-hwp-idcollab-1the environMENTAL consortium, 
    MCS    PRIME   

Mpc25-014

Mapping the Symptom Profile and Burden of Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome (ME/CFS): Insights from the TIMES Survey

Quote: Conclusions ME/CFS causes a heavy multi-system symptom burden. Although most individual symptoms were mild-moderately troublesome, the cumulative effect was severe or very severe. Fatigue was the most common and troublesome problem followed by cognitive symptoms, sleep disturbance and pain. Women experienced a greater symptom burden than men, and there was a moderate relationship between symptom burden and disease severity.
Abstract: https://www.medrxiv.org/content/10.64898/2026.06.17.26355870v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.06.17.26355870v1.full-text
Search Similar: Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho 
Search Authors: Sarah F Tyson Russell Fleming, 
    PRIME    DRUGS    PRACTICE   

Mph25-005

The Third Dimension of Pharmacokinetic"Pharmacodynamic Theory: Adaptive Rate Capacity as a Conserved Constraint on Biological Tolerability

Quote: Pharmacokineticpharmacodynamic theory describes drug action in two dimensions, magnitude and time, yet rate-dependent toxicity recurs across unrelated therapies without a unifying principle. We propose the Human Adaptive Rate Limit (HARL): every physiological system tolerates a maximum velocity of state change
Abstract: https://www.medrxiv.org/content/10.64898/2026.06.02.26354717v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.06.02.26354717v1.full-text
Search Similar: Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho 
Search Authors: Cornelis H Kleinbloesem Cornelis L Braal, 
    PRIME    NUTRITION    SLEEP   

Mph25-010

Consumer Opinions, Lot-to-Lot Variability, and Pharmacokinetics of Transdermal Melatonin Products: A Randomized, Crossover Clinical Trial

Quote: Oral (n11) and lotion formulations (n12) caused maximum salivary melatonin levels within 30 minutes after administration, but bath immersion did not cause increases in saliva melatonin (n17)....

Melatonin lotion may pose a risk to consumers who assume it is safe and less effective than oral tablets, when in fact it may be very potent and remain at high physiological levels into the following day.

Abstract: https://www.medrxiv.org/content/10.64898/2026.05.27.26354234v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.05.27.26354234v1.full-text
Search Similar: Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho 
Search Authors: Kathy Bonilla Vanessa M. Sherman Alba S. Arbaiza Mason Dougherty Lisa E. Olson, 
    PRIME    BRAIN    NUTRITION   

Mpy25-005

The relationship between serotonin transporter occupancy and extracellular serotonin concentration is hyperbolic, not linear: implications for safely tapering antidepressants

Quote: Conclusions Our model predicts a hyperbolic relationship between SERT occupancy and extracellular serotonin concentrations, suggesting that changes in occupancy may not map proportionally onto serotonergic effect. These findings provide a potential mechanistic explanation for dose-dependent clinical effects of SRIs despite plateauing transporter occupancy and generate testable hypotheses regarding antidepressant tapering strategies. Empirical validation is warranted.
Abstract: https://www.medrxiv.org/content/10.64898/2026.06.09.26355019v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.06.09.26355019v1.full-text
Search Similar: Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho 
Search Authors: Daniel Cohrs Bryan Shapiro, 
    PRIME    BRAIN    HEART    PHYSICAL    PRIVACY    PSYCHOLOGY   

Mpy25-008

Cardiac rhythm development: A wearable device index of risk for physical and mental illness in adolescence

Quote: Conclusions The 24-hour cardiac rhythm is a passively measurable substrate of adolescent autonomic development that indexes transdiagnostic risk for psychiatric and cardiometabolic illness. ...
Comment: Amazing. Yet it should not be, as everything is interconnected and a build-up of bio- brain errors and resulting questionable interpretations eventually drifts a person away from realistic interpretations.
Abstract: https://www.medrxiv.org/content/10.64898/2026.06.12.26355405v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.06.12.26355405v1.full-text
Search Similar: Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho 
Search Authors: Eugenia Giampetruzzi Katharina Kircanski Daniel S. Pine Ian H. Gotlib, 
    PRIME    BRAIN    COGNITION    PSYCHOLOGY    SLEEP   

Mpy25-013

Associations Between Social Responsiveness and Sleep disturbance are Modulated by Chronotype in Early Adolescence: Cross-Sectional and Prospective Findings from 10,108 Participants of the Adolescent Brain and Cognitive Development (ABCD) Study

Quote: Conclusions Social responsiveness assessed in early adolescence (age 11) were associated with sleep disturbance independent of multiple confounding factors and were prospectively associated with sleep disturbance at age 13 years. These findings contribute to the evidence that disruption of sleep and circadian timing may have a primary role in the mechanisms that mediate autistic traits.
Abstract: https://www.medrxiv.org/content/10.64898/2026.06.20.26356092v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.06.20.26356092v1.full-text
Search Similar: Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho 
Search Authors: Cathy Wyse Mailton Vasconcelos AungMyat Phyo Enya Nordon Lorna M. Lopez, 
    PRIME    CRIME    CULTURE   

Zza25-000

Citizen Vigilante Review: Cathartic Rebuttal to the Amoral One Battle After Another

Quote: Citizen Vigilante is a briskly-paced (at 89 minutes) low-budget exploitation movie told by a director who was long ago written off as a joke (Uwe Boll), using an unjustly disgraced star (Armie Hammer). The result? Despite the best efforts of left-wing censors, a brilliant guerrilla campaign has already driven it into the national conversation. Elon Musk then did what he does best: overturned the whole enchilada by releasing it to everyone for free on X. Basically, Citizen Vigilante is angry that European governments agree with One Battle After Another in that they refuse to enforce the law against the millions of unvetted migrants they imported who have brought their appalling and dangerous Third World values with them.
Comment: Shades of Bronson in Death Wish. Not that I watch that kind of stuff. I am, after all, a law abiding, civilized person.
Article: https://www.breitbart.com/entertainment/2026/06/26/citizen-vigilante-review-cathartic-rebuttal-to-the-amoral-one-battle-after-another/
Search Similar: Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho 
    PRIME    POLITICS   

Zzb25-003

Immigration: New Southern Border Caravan Spotlights Democrats Open Border Future

Quote: This reporting, the formation of still more "migrant" caravans heading north, should come as a stark warning for everyone and anyone who cares about the territorial integrity of the United States, for anyone who cares about the rule of law, specifically, our immigration laws. Mexico may be cooperating with the United States on border enforcement now, but that could very easily change the moment Democrats return to power and once more throw the floodgates open. If a Democrat, any Democrat, walks into the Oval Office in January of 2029, thats precisely what will happen.
Article: https://redstate.com/wardclark/2026/06/26/new-southern-border-caravan-spotlights-democrats-open-border-future-n2203751
Search Similar: Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho 
    PRIME    POLITICS   

Zzc25-000

Biden-Appointed Judge Blocks Trumps New Verification System to Remove Foreign Nationals from Voter Rolls

Quote: On Monday, Judge Sparkle Sooknanan, appointed to the United States District Court for the District of Columbia by Biden, issued an order to prevent the Trump administration from using a streamlined version of the federal governments SAVE program to combat voter fraud. The update to SAVE allowed states to more quickly verify that only American citizens are voting in federal elections by no longer requiring that all nine digits of a voter registrants Social Security Number have to be entered to verify eligibility.
Comment: Gioven the combined data is not legally combined, one can argue both ways on this issue. However, election integrity is logically of Primary Importance to our ability to govern our government as is the whole intent of our having The Constitution.
Article: https://www.breitbart.com/politics/2026/06/22/biden-judge-blocks-trump-from-using-verification-system-to-get-foreigners-off-voter-rolls/
Search Similar: Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho 
    PRIME    CRIME    POLITICS   

Zzc25-001

Elon Musk Is Now Taking Action After Ro Khanna Vows to Investigate Him for His USAID Actions

Quote: Sec. Rubio reveals USAID not only helped NGOs commit fraud but PURPOSEFULLY UNDERMINED and CONTRADICTED US State Department directives and interests in foreign nations THAT IS DE FACTO TREASON "It operated almost as an independent State Department, and often times pic.twitter.com/QuYbViADL1 Joni Job (jj_talking) June 22, 2026
Comment: Intersting things that Dept of Government Efficiency uncovered... And of course, the left wants to make sure it never happens again. That is, is never uncovered again.
Article: https://redstate.com/nick-arama/2026/06/22/elon-musk-reply-to-ro-khanna-n2203593
Search Similar: Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho 
    PRIME    WAR-CONFL   

Zzc25-002

Russia preparing hybrid attacks on NATOs eastern flank, intelligence warns

Quote: Putin is really worried about Ukrainian drone strikes: National security expert Lexington Institute vice president Dr. Rebecca Grant discusses the impact of Ukraines drone strikes on Russia and Moscows parade on Fox Report. NEWYou can now listen to Fox News articles Listen to this article 5 min Latvian intelligence is warning that Russia is preparing possible provocations against the Baltic states or Poland, including drones or any other hybrid attacks, in an effort to pressure NATO countries to stop supporting Ukraine. "We see indications that Russia is preparing military provocations against the Baltic countries or Poland not a conventional war, because Russia is not capable of that right now, but hybrid attacks, such as missiles, drones or other actions designed to send a signal: stop supporting Ukraine, or you will have your own problems," Latvian intelligence told Fox News Digital.
Article: https://www.foxnews.com/world/russia-preparing-hybrid-attacks-natos-eastern-flank-intelligence-warns
Search Similar: Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho 
    PRIME    POLITICS   

Zzc25-008

Something Weird Keeps Happening Now That Trump Neutered USAID

Quote: Center-right and conservative presidential candidates have swept to victory in Bolivia, Chile, Honduras, Costa Rica, Peru, and Colombia since Trump ordered the cancellation of the bulk of USAIDs programs. While its normal to see some political pendulum swinging, the speed and uniformity of the recent shift, coinciding with President Donald Trump neutering USAIDs democracy and governance funding apparatus, raise uncomfortable questions.
Article: https://dailycaller.com/2026/06/22/rooke-trump-usaid-funding-ngo-latin-america-elections-right-wing/
Search Similar: Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho 

  Javilk's Research Links for Week 25
Updated 06/27/2026-03:36:32 AM
What interests you? What have you found? Tell me!
Drop me a note to subscribe or submit something.