Research
Topics:
INDEX
MCS 3
PRIME 37
aging 18
brain 25
brainwave 4
cancer 20
climate 1
cognition 12
covid-19 3
crime 4
culture 4
dental 7
diabetes 7
diagnostics 4
disease 2
drugs 5
economy 2
exercise 2
eyes 1
genetics 7
gut 2
heart 11
immune 4
kidneys 2
language 3
lungs 2
metabolism 4
microbiome 4
misc 1
music 1
nutrition 16
obesity 2
pain 6
physical 1
politics 5
pollution 2
practice 2
privacy 2
psychology 12
reproduction 4
rights 1
sleep 5
soc-media
stress 1
tech 3
unk
vaccine 2
virus 2
war-confl
 
Scanned: 4202
Evaluated: 821
Selected: 129
 
    PRIME    MISC   

Bbc25-002

Discovery of CDK4-selective molecular glue degraders by high-throughput proteomics

Quote: Molecular glue degraders (MGDs) are proximity-inducing molecules that promote the destruction of disease-causing proteins by stabilizing novel interfaces between E3 ubiquitin ligases and target proteins....

This workflow led to the discovery of NE26394, a first-in-class MGD that selectively eliminates cyclin-dependent kinase 4 (CDK4), a critical oncogenic driver of cell cycle progression.

Article: https://www.biorxiv.org/content/10.64898/2026.06.19.733443v1
Search Similar: Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho 
Search Authors: Patrick R.A. Zanon Bachuki Shashikadze Denise Winkler Ines Scheller Anastasia Bednarz Denis Bartoschek Sophie Machata Tobias Graef Uli Ohmayer Bjoern Schwalb Martin Steger Henrik Daub, 
    MISC   

Mca25-002

Hyperleukocytosis and outcomes in pediatric B-cell acute lymphoblastic leukemia: A report from the REDIAL Consortium

Abstract: https://www.medrxiv.org/content/10.64898/2026.06.16.26355715v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.06.16.26355715v1.full-text
Search Similar: Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho 
Search Authors: Josiah J. Kim Austin L. Brown M. Monica Gramatges Thanh Hoang Pagna Sok Veronica Garcia-Morales Olga A. Taylor Van Huynh Kathleen Ludwig Laura J. Klesse Kenneth M. Heym Timothy Griffin Rodrigo Erana John Carlos Bernini M. Brooke Bernhardt Philip J. Lupo Karen R. Rabin Michael E. Scheurer Mark Zobeck, 

  Javilk's Research Links for Week 25
Updated 06/27/2026-03:36:32 AM
What interests you? What have you found? Tell me!
Drop me a note to subscribe or submit something.