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Mpy26-010

Cognitive-emotional responses to ultrasonic neuromodulation of anterior cingulate cortex

Quote: the largest effects (Cohens d #8764; 0.8) observed in pregenual and subgenual ACC in subjects with chronic pain and depression, respectively. These rapid trial-by-trial responses to ACC stimulation predicted subsequent improvements in pain and depression severity at 24 hours. Collectively, these findings reveal that transcranial ultrasound can robustly evoke immediate, target-specific, clinically meaningful changes in cognitive-emotional state, demonstrating the potential of ultrasonic neuromodulation as a tool for individualized probing of circuit function and dysfunction.
Abstract: https://www.medrxiv.org/content/10.64898/2026.06.22.26356085v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.06.22.26356085v1.full-text
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Search Authors: Brandon S. Cooper Vincent Koppelmans Thomas S. Riis Daniel A. Feldman Sarah Kwon Patrick Brashear Michael Guynn Akiko Okifuji Jan Kubanek Brian J. Mickey, 

  Javilk's Research Links for Week 26
Updated 07/04/2026-03:43:26 AM
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