| Research Topics: |
| INDEX |
| AI-chat 2 |
| MCS 2 |
| PRIME 35 |
| PRIO 1 |
| aging 10 |
| brain 12 |
| brainwave 2 |
| cancer 10 |
| climate 6 |
| cognition 7 |
| covid-19 1 |
| culture 2 |
| dental 1 |
| diabetes 5 |
| disease 2 |
| drugs 1 |
| economy 1 |
| election 1 |
| exercise 1 |
| gender 2 |
| genetics 3 |
| gut 5 |
| heart 6 |
| immune 5 |
| kidneys 3 |
| language 1 |
| metabolism 1 |
| microbiome 3 |
| misc 1 |
| nutrition 12 |
| obesity 1 |
| poison 1 |
| politics 5 |
| pollution 3 |
| privacy 3 |
| psychology 2 |
| reproduction 1 |
| rights 3 |
| sleep 1 |
| space 2 |
| unk |
| virus 1 |
|
Scanned: 1782 Evaluated: 279 Selected: 72 |
| MCS PRIME POISON POLLUTION | ||||||||
Bbc28-004 | A covalent irreversible inhibitor binds in two mutually exclusive conformations to the active-site cysteine residue of human aldehyde dehydrogenase 1A3 | |||||||
| Quote: | Biochemical and biophysical tests confirmed that Z34 acts as a time-dependent, covalent, and irreversible binder to the active-site cysteine. In this work, we determined the Cryo-EM structure of the ALDH1A3-Z34 complex at 2.26 resolution, confirming the covalent attachment to the catalytic cysteine of Z34. Notably, two mutually exclusive covalent binding modes were observed: one occupying the substrate-binding pocket and the other the cofactor-binding region. Z34 displayed unexpected binding modes within the active site and holds promise as a lead compound for future drug development. | |||||||
| Article: | https://www.biorxiv.org/content/10.64898/2026.07.14.738401v1 | |||||||
| Search Similar: | Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho | |||||||
| Search Authors: | Daniela Covaleda David Vizarraga Tulsi Upadhyay Jiyun Zhu Daniel Abegg Raquel Pequerul Martn Hugo Alexander Adibekian Ignacio Fita Xavier Pars Francesc Xavier Avils Matthew Boggyo Jaume Farrs, | |||||||
| PRIME CANCER POLLUTION | ||||||||
Sd281-004 | Why Are Healthy Young Non-smokers Developing Lung Cancer? | |||||||
| Quote: | According to Nieva, commercially grown (non-organic) fruits, vegetables, and whole grains generally contain higher levels of pesticide residues than dairy products, meat, and many processed foods. He also pointed to previous research showing that agricultural workers with long term pesticide exposure experience higher rates of lung cancer, adding support to the hypothesis. The study also found that women under 50 who have never smoked develop lung cancer more often than men in the same age group. Women in the study also tended to eat more fruits, vegetables, and whole grains than their male counterparts. | |||||||
| Article: | https://www.sciencedaily.com//releases/2026/07/260712011758.htm | |||||||
| Search Similar: | Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho | |||||||
| POLLUTION | ||||||||
Sd285-003 | Tiny Plastics in Drinking Water May Be Making Dangerous Bacteria Stronger | |||||||
| Quote: | The first stage would focus on warming the planet. Researchers envision increasing Marss average temperature by several tens of degrees over a few decades using engineered aerosols or greenhouse gases. Studies suggest Mars contains enough frozen water to eventually produce an ocean covering nearly four million square kilometers with an average depth of about 300 meters. Raising temperatures by roughly 30 degrees Celsius could begin melting those ice reserves, allowing stable liquid water to appear on the surface. | |||||||
| Article: | https://www.sciencedaily.com//releases/2026/07/260714225532.htm | |||||||
| Search Similar: | Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho | |||||||
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Javilk's Research Links for Week 28 Updated 07/17/2026-11:18:40 PM What interests you? What have you found? Tell me! Drop me a note to subscribe or submit something. |