PRIME AGING BRAIN COGNITION NUTRITION POLLUTION
Aee29-1024	Boron and Healing
	Quote:	"Administration of boron 5, 10, and 20 mg/kg/d reversed malathion-induced oxidative stress, lipid peroxidation, and suppression of antioxidant enzyme activity. Boron decreased malathion-induced oxidative stress, enhanced antioxidant defense mechanisms, and regenerated damaged liver, kidney, and brain tissues in rats." 1, 2 Curious Note: malathion is a pesticide.... Boron has been shown in animal and human studies to affect: Brain electrical activity and cognitive performance, including manual dexterity, attention, short-term memory, and long-term memory; Bone formation, mineralization, and fracture healing; The methylation cycle, specifically SAM-e (S-adenosylmethionine) production and homocysteine regulation; Steroid hormone metabolism including testosterone, estradiol, and vitamin D activation; Immune function, T-cell populations, immunoglobulin production, and cytokine balance...
	Article:	https://principia-scientific.com/the-borax-conspiracy-solved-its-not-a-conspiracy-its-worse/
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PRIME AGING HEART METABOLISM NUTRITION
Bbc29-007	Caloric Restriction Promotes Ischemia/Reperfusion Cardioprotection Through Increased Mitochondrial Na /Ca2 Exchange
	Quote:	These findings demonstrate that CR protects the heart from I/R injury by enhancing Na -dependent mitochondrial Ca2 efflux, thereby preserving mitochondrial function, limiting oxidative stress, and improving post-ischemic cardiac recovery.
	Comment:	Like chelation, Caloric Restriction helps remove calcium from the mitochondria, enabling them to run more efficiently in producing our energy.
	Article:	https://www.biorxiv.org/content/10.64898/2026.07.20.739602v1
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	Search Authors:	Maiara IC Queiroz Camille C Caldeira da Silva Marcos AE Cruz Julian DC Serna Luiz RG Bechara Julio CB Ferreira Heberty TF Facundo Alicia J Kowaltowski,
PRIME AGING BRAIN GENETICS
Mne29-009	Epigenetic Clock Trajectories and Brain Health in Midlife
	Quote:	Accelerated biological aging can be assessed with DNA methylation (DNAm)-based epigenetic clocks. Research suggests that greater DNAm is associated with faster cognitive decline and risk of Alzheimer disease (AD) and other dementias. ,,, Conclusion Middle-aged adults with faster 15-year epigenetic aging trajectories demonstrated worse cognitive performance, whereas those with slower biological aging trajectories exhibited cognitive resilience and more favorable AD biomarker profiles. By examining long-term trajectories rather than single timepoints, these findings identify individuals at differential risk for brain health outcomes.
	Abstract:	https://www.medrxiv.org/content/10.64898/2026.07.16.26358251v1
	Full Text:	https://www.medrxiv.org/content/10.64898/2026.07.16.26358251v1.full-text
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	Search Authors:	Ana I. Boeriu Shea J. Andrews Tina Hoang Sejong Bae Kristine Yaffe,
PRIME AGING BRAIN SLEEP
Sd291-001	Alzheimers Breakthrough: Scientists Restore Two Hours of Sleep Without Clearing Brain Plaques
	Quote:	"Basically, we showed that it is not the plaques themselves, or solely dysfunctional neurons, that cause sleep loss but actually microglia," said Macauley. "Microglia are immune cells that, when they respond to plaques, kick off this elaborate cascade of inflammation, as if the microglia are partying all night, and keeping the brain awake."
	Article:	https://www.sciencedaily.com//releases/2026/07/260719035931.htm
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AGING BRAIN
Sd291-003	Scientists Discover a Protein That Protects the Brain from Alzheimers Damage
	Quote:	A protein called SORLA may act as a powerful defense against the toxic tau tangles involved in Alzheimers disease. Mice with extra SORLA had less tau accumulation, less brain atrophy
	Article:	https://www.sciencedaily.com//releases/2026/07/260718010140.htm
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AGING STRESS
Sd291-009	Coffee May Help the Body Fight Stress and Aging Through a Hidden Cellular Switch
	Quote:	Studies have connected NR4A1 with inflammation, metabolism and tissue repair. Each of these processes is closely involved in age-related conditions, including cancer, neurodegenerative disease and metabolic disorders. A Possible Mechanism Behind Coffees Benefits Large observational studies have linked coffee consumption with a reduced risk of Alzheimers disease, Parkinsons disease and metabolic disease. However, those studies have generally shown associations rather than explaining exactly how coffee might produce protective effects. Safe and his team proposed that NR4A1 could be one part of that explanation.
	Article:	https://www.sciencedaily.com//releases/2026/07/260719035927.htm
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PRIME AGING BRAIN
Sd291-013	Popular Sugar Substitutes Linked to Faster Brain Aging
	Quote:	Several popular sugar substitutes may not be as harmless as they seem. Adults who consumed the most artificial sweeteners showed substantially faster declines in memory and thinking, especially if they were under 60 or had diabetes. The highest intake was linked to cognitive aging roughly 1.6 years faster than the lowest intake. Researchers stressed that more studies are needed before concluding that sweeteners are the cause.
	Article:	https://www.sciencedaily.com//releases/2026/07/260717033213.htm
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Javilk's Research Links Newsletter for Week 29
Updated 07/25/2026-03:15:16 AM
What interests you? What have you found? Tell me!
Drop me a note to subscribe or submit something.

Aee29-1024

Boron and Healing

Bbc29-007

Caloric Restriction Promotes Ischemia/Reperfusion Cardioprotection Through Increased Mitochondrial Na /Ca2 Exchange

Mne29-009

Epigenetic Clock Trajectories and Brain Health in Midlife

Sd291-001

Alzheimers Breakthrough: Scientists Restore Two Hours of Sleep Without Clearing Brain Plaques

Sd291-003

Scientists Discover a Protein That Protects the Brain from Alzheimers Damage

Sd291-009

Coffee May Help the Body Fight Stress and Aging Through a Hidden Cellular Switch

Sd291-013

Popular Sugar Substitutes Linked to Faster Brain Aging