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Sd294-004

Natural Compound May Fight Rheumatoid Arthritis at Its Source

Quote: A natural compound called obakulactone (OL) may offer a new way to treat rheumatoid arthritis (RA), according to a study published in Engineering. OL is a tetracyclic triterpenoid isolated from Phellodendri cortex. Researchers found that it reduced signs of arthritis by promoting the breakdown of acyl coenzyme A thioesterase 1 (ACOT1) through the ubiquitin#8210;proteasome pathway and by restoring the balance of unsaturated fatty acids. The findings help explain how OL acts on rheumatoid arthritis at the molecular level. They also identify ACOT1 as a possible new drug target and suggest that correcting disrupted fatty acid metabolism could become a useful strategy for treating RA.
Article: https://www.sciencedaily.com//releases/2026/07/260721000845.htm
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  Javilk's Research Links Newsletter for Week 29
Updated 07/25/2026-03:15:16 AM
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