PRIME AGING BRAIN COGNITION NUTRITION POLLUTION
Aee29-1024	Boron and Healing
	Quote:	"Administration of boron 5, 10, and 20 mg/kg/d reversed malathion-induced oxidative stress, lipid peroxidation, and suppression of antioxidant enzyme activity. Boron decreased malathion-induced oxidative stress, enhanced antioxidant defense mechanisms, and regenerated damaged liver, kidney, and brain tissues in rats." 1, 2 Curious Note: malathion is a pesticide.... Boron has been shown in animal and human studies to affect: Brain electrical activity and cognitive performance, including manual dexterity, attention, short-term memory, and long-term memory; Bone formation, mineralization, and fracture healing; The methylation cycle, specifically SAM-e (S-adenosylmethionine) production and homocysteine regulation; Steroid hormone metabolism including testosterone, estradiol, and vitamin D activation; Immune function, T-cell populations, immunoglobulin production, and cytokine balance...
	Article:	https://principia-scientific.com/the-borax-conspiracy-solved-its-not-a-conspiracy-its-worse/
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BRAIN
Bbc29-014	Isolation and Lipidomic Profiling of Neuronal Lipid Droplets: Unveiling the Lipid Landscape of Neurodegenerative Disorders
	Quote:	Neuronal LDs, whose existence has long been debated, have now been identified in several neural structures, raising questions about their contribution to neurodegenerative disorders. Elucidating the specific chemical makeup of these organelles within neurons is critical for understanding their role in neural pathologies. However, the inherent submicron size and low abundance in neurons have posed challenges in their isolation
	Article:	https://www.biorxiv.org/content/10.1101/2023.12.13.571527v2
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	Search Authors:	Mukesh Kumar Rachel Mcallister Souvik Roy Justin Knapp Kallol Gupta Timothy A Ryan,
BRAIN COGNITION PSYCHOLOGY
Bne29-011	miR-10a-5p as a critical molecular regulator of dopaminergic impulsivity in the nucleus accumbens
	Quote:	Among the differentially expressed miRs, miR-10a-5p emerged as the strongest candidate: it was constitutively elevated in high-impulsive rats and upregulated by PPX in low- and mid-impulsive animals in both regions, thereby paralleling the trait-dependent behavioral effect of the drug. In vivo viral-mediated overexpression of miR-10a-5p confirmed its predicted downregulation of the PI3KAKTmTOR and BDNF pathways in the striatum, and, critically, overexpression restricted to the NAcc, but not the dorsal striatum, was sufficient to increase impulsive choice, recapitulating the pro-impulsive effect of PPX. These findings identify miR-10a-5p as a critical molecular regulator of impulsivity through its activity in the NAcc, providing a mechanistic link between dopaminergic perturbation, trait vulnerability, and ICDs, and opening new avenues for the development of miR-directed therapeutic strategies for these disorders.
	Article:	https://www.biorxiv.org/content/10.64898/2026.07.20.739499v1
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	Search Authors:	Yury V M Lages Thibault Dufourd Carole Carcenac Mathilde Roux Magali Bartolomucci Frederique Vossier David Mallet Robin Magnard Colin Deransart sabrina Boulet Pierre-Olivier Fernagut Sebastien Carnicella,
PRIME AGING BRAIN GENETICS
Mne29-009	Epigenetic Clock Trajectories and Brain Health in Midlife
	Quote:	Accelerated biological aging can be assessed with DNA methylation (DNAm)-based epigenetic clocks. Research suggests that greater DNAm is associated with faster cognitive decline and risk of Alzheimer disease (AD) and other dementias. ,,, Conclusion Middle-aged adults with faster 15-year epigenetic aging trajectories demonstrated worse cognitive performance, whereas those with slower biological aging trajectories exhibited cognitive resilience and more favorable AD biomarker profiles. By examining long-term trajectories rather than single timepoints, these findings identify individuals at differential risk for brain health outcomes.
	Abstract:	https://www.medrxiv.org/content/10.64898/2026.07.16.26358251v1
	Full Text:	https://www.medrxiv.org/content/10.64898/2026.07.16.26358251v1.full-text
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	Search Authors:	Ana I. Boeriu Shea J. Andrews Tina Hoang Sejong Bae Kristine Yaffe,
BRAIN COGNITION GENDER REPRODUCTION
Mne29-010	From Menarche to Menopause: Hormonal Influences on Functional Neurological Disorder
	Abstract:	https://www.medrxiv.org/content/10.64898/2026.07.16.26358260v1
	Full Text:	https://www.medrxiv.org/content/10.64898/2026.07.16.26358260v1.full-text
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	Search Authors:	David D. G. Palmer Nicola Warren Adam Morton Alexander Lehn,
BRAIN PSYCHOLOGY STRESS
Mpy29-005	Revisiting the link between childhood adversity and stress-sensitive brain regions in psychosis and bipolar disorder: A systematic review and meta-analysis
	Quote:	Conclusion Childhood Aadversity was not consistently associated with hippocampal or amygdala volume alterations in PD and BD. More consistent evidence emerged for reduced GMV in prefrontal regions, suggesting that neurobiological impact of CA may be more robustly captured at the cortical level.
	Abstract:	https://www.medrxiv.org/content/10.64898/2026.07.17.26358306v1
	Full Text:	https://www.medrxiv.org/content/10.64898/2026.07.17.26358306v1.full-text
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	Search Authors:	Teya Petrova Andreas Tennifjord Daniela Cavero Aisling Holohan Melissa Kizilkaya Ava Ebrahimian-Roodbari Ines Lepreux Marie Reimer Lucia Sideli Romayne Gadelrab Giulia Trotta Victoria Rodriguez Ole Andreassen Paul Klauser Luis Alameda Monica Aas,
PRIME AGING BRAIN SLEEP
Sd291-001	Alzheimers Breakthrough: Scientists Restore Two Hours of Sleep Without Clearing Brain Plaques
	Quote:	"Basically, we showed that it is not the plaques themselves, or solely dysfunctional neurons, that cause sleep loss but actually microglia," said Macauley. "Microglia are immune cells that, when they respond to plaques, kick off this elaborate cascade of inflammation, as if the microglia are partying all night, and keeping the brain awake."
	Article:	https://www.sciencedaily.com//releases/2026/07/260719035931.htm
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AGING BRAIN
Sd291-003	Scientists Discover a Protein That Protects the Brain from Alzheimers Damage
	Quote:	A protein called SORLA may act as a powerful defense against the toxic tau tangles involved in Alzheimers disease. Mice with extra SORLA had less tau accumulation, less brain atrophy
	Article:	https://www.sciencedaily.com//releases/2026/07/260718010140.htm
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PRIME AGING BRAIN
Sd291-013	Popular Sugar Substitutes Linked to Faster Brain Aging
	Quote:	Several popular sugar substitutes may not be as harmless as they seem. Adults who consumed the most artificial sweeteners showed substantially faster declines in memory and thinking, especially if they were under 60 or had diabetes. The highest intake was linked to cognitive aging roughly 1.6 years faster than the lowest intake. Researchers stressed that more studies are needed before concluding that sweeteners are the cause.
	Article:	https://www.sciencedaily.com//releases/2026/07/260717033213.htm
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Javilk's Research Links Newsletter for Week 29
Updated 07/25/2026-03:15:16 AM
What interests you? What have you found? Tell me!
Drop me a note to subscribe or submit something.

Aee29-1024

Boron and Healing

Bbc29-014

Isolation and Lipidomic Profiling of Neuronal Lipid Droplets: Unveiling the Lipid Landscape of Neurodegenerative Disorders

Bne29-011

miR-10a-5p as a critical molecular regulator of dopaminergic impulsivity in the nucleus accumbens

Mne29-009

Epigenetic Clock Trajectories and Brain Health in Midlife

Mne29-010

From Menarche to Menopause: Hormonal Influences on Functional Neurological Disorder

Mpy29-005

Revisiting the link between childhood adversity and stress-sensitive brain regions in psychosis and bipolar disorder: A systematic review and meta-analysis

Sd291-001

Alzheimers Breakthrough: Scientists Restore Two Hours of Sleep Without Clearing Brain Plaques

Sd291-003

Scientists Discover a Protein That Protects the Brain from Alzheimers Damage

Sd291-013

Popular Sugar Substitutes Linked to Faster Brain Aging