Research
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Scanned: 2595
Evaluated: 284
Selected: 69

 
    PRIME    AGING    HEART    METABOLISM    NUTRITION   

Bbc29-007

Caloric Restriction Promotes Ischemia/Reperfusion Cardioprotection Through Increased Mitochondrial Na /Ca2 Exchange

Quote: These findings demonstrate that CR protects the heart from I/R injury by enhancing Na -dependent mitochondrial Ca2 efflux, thereby preserving mitochondrial function, limiting oxidative stress, and improving post-ischemic cardiac recovery.
Comment: Like chelation, Caloric Restriction helps remove calcium from the mitochondria, enabling them to run more efficiently in producing our energy.
Article: https://www.biorxiv.org/content/10.64898/2026.07.20.739602v1
Search Similar: Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho 
Search Authors: Maiara IC Queiroz Camille C Caldeira da Silva Marcos AE Cruz Julian DC Serna Luiz RG Bechara Julio CB Ferreira Heberty TF Facundo Alicia J Kowaltowski, 
    METABOLISM   

Bbc29-008

Proximity Labelling Reveals Spatial Organisation of Mitochondrial Protein Import Complexes

Quote: Mitochondrial protein import and local translation at the mitochondrial outer membrane (MOM) require coordinated interactions between protein translocases and RNA-associated factors, yet the molecular organisation of these interactions remains largely unresolved. Here, we used APEX2-mediated proximity labelling to define the proximal proteomes associated with the cytosolic face of the TOM and SAM complexes by fusing APEX2 to TOMM22 and MTX2, respectively.
Article: https://www.biorxiv.org/content/10.64898/2026.07.20.739561v1
Search Similar: Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho 
Search Authors: Xu Wang Claudia Cavarischia-Rega Boris Macek Ralf-Peter Jansen, 
    DIABETES    METABOLISM    OBESITY   

Bpt29-014

Dronedarone hydrochloride reverses obesity-related metabolic syndrome while preserving skeletal muscle mass

Quote: Mechanistically, dronedarone hydrochloride operates independently of central hypothalamic appetite-regulating neuropeptides and the peripheral leptin pathway. By decoupling fat reduction from sarcopenia, our findings establish dronedarone hydrochloride as a muscle-sparing therapeutic candidate for metabolic syndrome.
Article: https://www.biorxiv.org/content/10.64898/2026.07.20.739085v1
Search Similar: Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho 
Search Authors: Jiaxin Lei Xiaoxun Zhang xinyu cao zhixian zhu fei ye ziqian xu wenrong su xinyue zeng zuzhi xu jingdong zhao siyi jiang nan zhao Huaizheng Liu Yan Lu Chuanzheng Sun Jin Chai, 

  Javilk's Research Links Newsletter for Week 29
Updated 07/25/2026-03:15:16 AM
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