Research
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PRIME 37

aging 12

body 2

brain 17

eyes 1

gut 3

heart 15

tech 2

unk

Scanned: 3012
Evaluated: 322
Selected: 92

PRIME BODY COGNITION NUTRITION PHYSICAL
Aef32-1013	Schioliosis, the Serotonin Connection
	Quote:	Abstract Recent research has suggested a potential association between serotonin and idiopathic scoliosis, a complex spinal deformity of unknown origin. Studies have explored genetic associations, altered serotonin levels, and the effects of serotonin-related medications in the context of idiopathic scoliosis. Genetic studies have identified significant associations between idiopathic scoliosis and serotonin-related genes, indicating a potential genetic predisposition to the condition. Furthermore, altered serotonin levels have been observed in patients with idiopathic scoliosis, with lower serum serotonin levels reported compared to healthy controls. This chapter reviews some of the published genomic variants associated with idiopathic scoliosis. The effects of serotonin-related medications have also been investigated, highlighting potential therapeutic benefits. However, the exact mechanisms underlying the association between serotonin and idiopathic scoliosis remain unclear, warranting further research. While theoretical and animal models have shown connections between serotonin metabolism and idiopathic scoliosis, there are uncertainties when translating this information into clinical practice for primary care and other musculoskeletal specialty providers. This chapter outlines the serotonergic pathways of musculoskeletal function, serotonin clinical laboratory testing methods, as well as clinical management strategies including pharmacological, nutrient, dietary, and lifestyle-based options. Keywords genomicsposturescoliosisserotoninspine Author Information Show 1. Introduction Serotonin, also known as 5-hydroxytryptamine (5-HT), is a neurotransmitter that plays a crucial role in the central nervous system (CNS). It is derived from the amino acid tryptophan and is involved in numerous physiological functions, including mood regulation, sleep, appetite, and cognition. Structurally, serotonin is a monoamine neurotransmitter with a chemical formula of C10H12N2O. It contains an indole ring and an amine group, making it a member of the indoleamine class of neurotransmitters. Serotonin exerts its effects by binding to specific receptors, mainly the 5-HT receptors, which are widely distributed throughout the brain and other tissues. While serotonins involvement in mental health disorders like depression and anxiety is well-established, recent research has also highlighted its potential role in the pathogenesis of idiopathic scoliosis, a complex spinal deformity of unknown origin.
	Article:	https://www.intechopen.com/chapters/1157328
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PRIME NUTRITION PHYSICAL
Aef32-1019	Evaluation of GPR50, hMel-1B, and ROR-Alpha Melatonin-Related Receptors and the Etiology of Adolescent Idiopathic Scoliosis
	Quote:	Despite the observed relationship between melatonin and scoliosis, there is no significant association between mutations found in any known melatonin-related receptors with adolescent idiopathic scoliosis. The strong evidence of a melatonin-related cause for the development of idiopathic scoliosis still encourages research into undiscovered melatonin-related receptors, melatonin-related hormones, and the catalytic enzymes for the serotonin-melatonin pathway.
	Article:	https://pmc.ncbi.nlm.nih.gov/articles/PMC2928583/
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Javilk's Research Links Newsletter for Week 32
Updated 08/15/2026-01:24:35 AM
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