MCS PRIME AGING LYME
Aef33-1001	RFK Jr., Dennis Quaid Announce New HHS Push on Lyme, Tick-Borne Disease: Faster Diagnoses, Real Answers
	Quote:	Quaid appeared alongside Kennedy as a patient advocate and recounted the case of his late friend, singer and actor Kris Kristofferson, who spent years carrying an Alzheimers diagnosis. "But Alzheimers wasnt the problem," Quaid said. "He actually had Lyme disease and when the doctors finally diagnosed him correctly in 2016 and started the right treatment, his symptoms did improve." Kennedy urged recovered patients and those with lingering symptoms to submit their treatment histories through Cure ID, the free FDA and NIH app that collects real-world data. He said patients without a trusted provider can use the clinician locator at hhs.gov/lyme to find experienced doctors by zip code.
	Article:	https://www.breitbart.com/health/2026/08/17/rfk-jr-dennis-quaid-hhs-lyme-tick-borne-disease/
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	Search Authors:	"On January 25, 2021, Dr. John Mascola, the then-Director of the Vaccine Research Center at the National Institute of Allergy and Infectious Diseases, texted Dr. Fauci: "I am corrected on pregnancy studies. Initial Studies avoid vaccination in first trimester due to possible fever and higher rates of miscarriage in first trimester,
PRIME AGING
Bge33-002	Physics-Informed Modeling of Biological Aging through DNA Methylation Entropy
	Quote:	The model was evaluated across independent cohorts using the ComputAgeBench epigenetic clock benchmark. Stacy-GB achieved a mean absolute error (MAE) of 3.74 years and a median error (bias) of 2.41 years, significantly outperforming state-of-the-art epigenetic clock baselines. Furthermore, age acceleration estimated by Stacy-GB was associated with several clinical pathologies, including ischemic heart disease, HIV infection, multiple sclerosis, and Werner syndrome, supporting its potential as an accurate and biophysically grounded tool for clinical aging research.
	Article:	https://www.biorxiv.org/content/10.64898/2026.08.15.745036v1
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	Search Authors:	Hosein Nasrolahpour Ales Jandera Tomas Skovranek Vladimir Despotovic Matteo Pellegrini,
AGING COGNITION GENETICS
Mge33-002	Genome-wide analyses reveal shared and distinct genetic architecture linking amyotrophic lateral sclerosis, sporadic frontotemporal dementia and cognitive traits
	Quote:	These findings indicate that the cognitive dimension of ALS has its own locus-resolved genetic architecture, distinct in part from its relationship to sFTD and identify MEF2C, UNC13A and, recurrently, the MAPT/17q21.31 locus as top-ranked pleiotropic candidates for ALS-COG, ALS-sFTD and sFTD-COG respectively.
	Abstract:	https://www.medrxiv.org/content/10.64898/2026.08.17.26360494v1
	Full Text:	https://www.medrxiv.org/content/10.64898/2026.08.17.26360494v1.full-text
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	Search Authors:	Emrah Kacar Tomas DS Gomes Ciara ODonoghue Guste Venslovaite Orla Hardiman Russell Lewis McLaughlin Ross Patrick Byrne,
AGING BRAIN
Sd331-004	A Little-known Protein May Be Fueling Alzheimers " And Scientists Found a Way to Block It
	Quote:	GRK2 plays an important regulatory role in many human cells. It helps cells respond appropriately to signals, stress, and strain. The enzyme is active in organs including the heart and the brain, where it helps support normal nerve cell function. By analyzing the Cairo tissue samples at the molecular level and conducting experiments in mice, Quitterer and her colleagues uncovered evidence that GRK2 plays an important role in dementia. Their findings were recently published in the journal Cell Reports Medicine.
	Article:	https://www.sciencedaily.com//releases/2026/08/260814235856.htm
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AGING EXERCISE PAIN
Sd331-007	The Common Mistake That Could Make Aging Joints Hurt More
	Quote:	Aging gradually wears down the cartilage and fluid that protect our joints, but avoiding movement may actually make matters worse. Exercise helps nourish cartilage, strengthens the muscles that protect joints, and can reduce osteoarthritis pain. Low-impact activities such as swimming, cycling, tai chi, yoga, and walking on varied terrain may also improve balance and mobility. Even a few minutes of the right kind of movement can make a difference.
	Article:	https://www.sciencedaily.com//releases/2026/08/260814235852.htm
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AGING PHYSICAL
Sd331-009	Scientists Reveal Why Walking Gets so Much Harder with Age
	Quote:	The researchers found that older adults are more likely to activate opposing muscles around the ankle at the same time. This pattern is known as co-contraction. It makes the ankle joint stiffer and can improve stability when the foot contacts the ground. However, Dr. Lindsay says this comes at a cost. "Stiffening the joint makes walking safer, but it also means the muscles are working harder without generating as much forward movement," he says.
	Article:	https://www.sciencedaily.com//releases/2026/08/260815065014.htm
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PRIME AGING BRAIN IMMUNE
Sd331-014	Immune Cells Flood Into the Aging Brain, Stanford Scientists Discover
	Quote:	Scientists have discovered that the aging human brain may be far less isolated from the rest of the body than once believed. Stanford researchers found that large numbers of immune cells from the blood begin entering the brain as early as middle age, where they can transform into microglia, the brains specialized immune cells. The finding overturns a long-standing assumption that these cells remain largely separate from the bodys immune system throughout life.
	Article:	https://www.sciencedaily.com//releases/2026/08/260814011033.htm
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PRIME AGING BRAIN
Sd331-016	Women Taking Estrogen Had Fewer Signs of Alzheimers in Their Brains
	Quote:	Women who used estrogen-only hormone therapy later in life were less likely to develop dementia and showed fewer signs of Alzheimers disease in their brains, according to a large study of more than 21,000 participants. Hormone therapy use was linked to 39 lower odds of a dementia diagnosis and 35 lower odds of Alzheimers-related brain changes at autopsy
	Article:	https://www.sciencedaily.com//releases/2026/08/260814011028.htm
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Javilk's Research Links Newsletter for Week 33
Updated 08/22/2026-02:37:36 AM
What interests you? What have you found? Tell me!
Drop me a note to subscribe or submit something.

Aef33-1001

RFK Jr., Dennis Quaid Announce New HHS Push on Lyme, Tick-Borne Disease: Faster Diagnoses, Real Answers

Bge33-002

Physics-Informed Modeling of Biological Aging through DNA Methylation Entropy

Mge33-002

Genome-wide analyses reveal shared and distinct genetic architecture linking amyotrophic lateral sclerosis, sporadic frontotemporal dementia and cognitive traits

Sd331-004

A Little-known Protein May Be Fueling Alzheimers " And Scientists Found a Way to Block It

Sd331-007

The Common Mistake That Could Make Aging Joints Hurt More

Sd331-009

Scientists Reveal Why Walking Gets so Much Harder with Age

Sd331-014

Immune Cells Flood Into the Aging Brain, Stanford Scientists Discover

Sd331-016

Women Taking Estrogen Had Fewer Signs of Alzheimers in Their Brains