Stochastic Boolean Model of Death Signaling in MCF7:5C Predicts Cell Death Inducers and Inhibitors

Targeting Macrophage Connexin 43 Hemichannels Suppresses Synovial Inflammation and Osteoarthritis

Cysteine reduction rather than methionine restriction promotes immunometabolic fitness to confer survival benefit in aging

Rare extreme polygenic risk scores strongly indicate Alzheimers disease risk

Shared genetic architecture between brain iron deposition and Alzheimers disease

Impulse Control Disorders Are Independent of Parkinson Disease Motor Subtypes

These findings suggest that motor subtype-associated differences in cerebellar involvement do not substantially influence ICD symptoms in early PD.

Childhood trauma, accelerated biological aging and chronic pain across two population cohorts

Findings CT was associated with chronic pain and with accelerated biological aging measured primarily using second- and third-generation clocks. Associations were consistently stronger in women, and smoking-related methylation contributed substantially to the relationship between EAA and chronic pain. Mediation analyses revealed that EAA partially accounts for the link between CT and chronic pain in women.

Popular Brain Supplement Linked to Shorter Lifespan in Men

Alzheimers Screening and Prevention (ASAP) Act.

Thankfully, a solution is on the table to help clear a path for patients to benefit from these advances: the Alzheimers Screening and Prevention (ASAP) Act. The ASAP Act would allow Medicare coverage of FDA-cleared blood tests for routine Alzheimers screening. Experts agree that expanding access to early screening must be the starting point for addressing this crisis.