PRIME AGING
Ad372-004	Scientists Reversed Biological Age in Older Adults in Just 4 Weeks
	Quote:	New research from the University of Sydney found that Australians aged 65 to 75 who reduced either dietary fat or animal-based protein showed signs of a lower biological age after just four weeks. Biological age is an estimate of how old the body appears based on its health and physiological condition, rather than the number of years a person has been alive.
	Comment:	Not that simple...
	Article:	https://www.sciencedaily.com//releases/2026/09/260915100000.htm
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PRIME AGING CANCER
Ad372-040	Most Men Dont Know Dairy Is Linked to Prostate Cancer Risk
	Quote:	Most men may be missing an important dietary clue about prostate cancer. A new survey found that only 20 knew research has linked dairy consumption with increased prostate cancer risk, while 66 said they would consider avoiding dairy after learning about the connection. Studies have also associated plant-based diets with substantially lower risks of prostate cancer
	Article:	https://www.sciencedaily.com//releases/2026/09/260911214259.htm
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AGING
Mge37-022	Lysosomal polygenic risk score in Parkinsons disease across populations.
	Abstract:	https://www.medrxiv.org/content/10.64898/2026.09.14.26362981v1
	Full Text:	https://www.medrxiv.org/content/10.64898/2026.09.14.26362981v1.full-text
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	Search Authors:	Wenhua Sun Kathrin Brockmann Isabel Wurster Roswitha Kemmner Benjamin Roeben Reda Skaiene Stefanie Lerche Claudia Schulte Thomas Gasser Manuela Tan span classnlm-collab data-hwp-idcollab-1the Global Parkinsons Genetic Program (GP2),
AGING
Mgr37-002	Feasibility, Safety, and Preliminary Efficacy of Partnered Rhythmic Rehabilitation in Prodromal Alzheimers Disease: A 12-Month Pilot Randomized Controlled Trial
	Quote:	Conclusion: PRR was feasible and safe in adults with aMCI consistent with pAD but did not meet the prespecified efficacy endpoint on FSST. Our results showed that TUG and standing board jump distance may serve as potential outcomes in future definitive trials.
	Abstract:	https://www.medrxiv.org/content/10.64898/2026.09.11.26362767v1
	Full Text:	https://www.medrxiv.org/content/10.64898/2026.09.11.26362767v1.full-text
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	Search Authors:	Forouzan Rafiei Rezvani Daniel Azimi Amir H. Nekouei Haneul Kim Cathleen.C Sauer Whitney Wharton Deqiang Qiu Felicia Goldstein JL McKay Madeleine E. Hackney,
AGING BRAIN
Mne37-002	GFAP as a Biomarker of Stroke Subtype and Brain Tissue Damage in Acute Stroke: A Systematic Review and Meta-Analysis
	Quote:	Background: Glial fibrillary acidic protein (GFAP) is a promising blood biomarker that can distinguish intracerebral hemorrhage (ICH) from acute ischemic stroke (AIS).... Conclusions: As a blood biomarker in acute stroke, GFAP has strong rule-in value (i.e. high specificity) for ICH, which is preserved in earlier time windows. Nevertheless, sensitivity remains limited, restricting its use as a rule-out test, particularly for smaller ICH volumes. Knowledge gaps remain regarding GFAPs potential in assessing ischemic injury extent in AIS.
	Abstract:	https://www.medrxiv.org/content/10.64898/2026.09.11.26362885v1
	Full Text:	https://www.medrxiv.org/content/10.64898/2026.09.11.26362885v1.full-text
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	Search Authors:	Catherine Brassard Julien F Paul Daniela ZIEGLER Miguel Chagnon Olena Bereznyakova Mark R Keezer Laura C. Gioia,
PRIME AGING COGNITION GENDER
Mne37-007	Sex and Life Stage Differences in the Association Between Cognitive Engagement and Cognitive Change
	Comment:	Interesting read, too much to include here.
	Abstract:	https://www.medrxiv.org/content/10.64898/2026.09.11.26362841v1
	Full Text:	https://www.medrxiv.org/content/10.64898/2026.09.11.26362841v1.full-text
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	Search Authors:	Sarah Goulding Shima Raeesi John A E Anderson Michael D. A E Oliver Lisa L. Barnes Mayra Estrella Mahsa Dadar Cassandra Morrison,
AGING
Mne37-013	Antihypertensive Medication Class and Incident Alzheimers Disease and Related Dementias: External Replication Across Two Independent Healthcare Data Sources-the Vanderbilt EHR Synthetic Derivative and US Medicare Claims
	Quote:	Conclusions and Relevance. Across two structurally independent data sources, the predominant use of antihypertensive medications that stimulate angiotensin II type 2 and type 4 receptor signaling was associated with a modestly lower risk of incident ADRD compared with predominantly inhibiting agents. By replicating in two distinct data environments, these findings extend prior single-source pharmacoepidemiologic evidence and support evaluation of receptor targeted antihypertensive strategies for cognitive outcomes in randomized comparative-effectiveness trials.
	Abstract:	https://www.medrxiv.org/content/10.64898/2026.09.11.26362859v1
	Full Text:	https://www.medrxiv.org/content/10.64898/2026.09.11.26362859v1.full-text
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	Search Authors:	Anshul Tiwari Rui Chen Yuting Tan Yan Yan Zhexing Wen Wei-Qi Wei Xue Zhong Bingshan Li,
PRIME AGING COGNITION
Mne37-015	Accelerometer-Derived Relative Amplitude and Midlife Cognition: A Cross-Sectional Study
	Quote:	Conclusions and Relevance: Among midlife adults recruited from primary care practices, lower relative amplitude was associated with modestly poorer fluid cognitive performance after adjustment for established dementia risk factors and sleep characteristics. Relative amplitude may represent a scalable behavioral correlate of cognitive variability within the normative range. Longitudinal studies beginning in midlife are needed to establish temporality, predictive value, or modifiability.
	Abstract:	https://www.medrxiv.org/content/10.64898/2026.09.15.26361208v1
	Full Text:	https://www.medrxiv.org/content/10.64898/2026.09.15.26361208v1.full-text
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	Search Authors:	Minjee Kim Morgan Bonham Fangyu Yeh Marisol Arredondo Lauren Opsasnick Laura Curtis Stacy C. Bailey Julia Y. Benavente Emily H. Ho Paul Chung Danielle Wallace Mary Kwasny Jeffrey A. Linder Michael S. Wolf Phyllis C. Zee,
AGING GENDER HEART
Mne37-019	Sex-Specific Associations of Carotid Plaque Calcification Subtypes with Stroke, TIA, and Retinal Ischemia
	Quote:	Conclusions Overall, symptomatic plaques showed lower total and sheet calcification than asymptomatic plaques. PI2.1In men, low total and sheet calcification were associated with stroke, whereas higher nodular calcification was associated with retinal infarction. In women, high total calcification was associated with TIA. These findings suggest that although calcification appears to be a stabilization plaque feature, its clinical implications depend on its morphological subtype and vary according to sex and neurological symptom subtype.
	Abstract:	https://www.medrxiv.org/content/10.64898/2026.09.14.26363078v1
	Full Text:	https://www.medrxiv.org/content/10.64898/2026.09.14.26363078v1.full-text
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	Search Authors:	Henna Juulia Komi Petra Hannele Ijs Krista Nuotio Laura Mkitie Mikko I Myrnp Mohammadreza Shoghli Riikka Tulamo Pirkka Juha Vikatmaa Perttu J Lindsberg Lauri Soinne Suvi M Koskinen Juha Sinisalo A. Inkeri Lokki,
AGING HEART
Mne37-022	Identification of Plasma Protein Biomarkers for Early-Onset Stroke through Mendelian Randomization
	Quote:	Conclusions This large-scale proteome-wide MR study identified multiple plasma proteins with likely causal roles in EOS, implicating coagulation, platelet activation, extracellular matrix remodeling, and immune pathways in disease etiology. These findings highlight biologically plausible biomarkers and prioritize druggable targets, particularly Factor XI, for prevention of EOS and demonstrate the value of proteogenomic approaches for uncovering disease mechanisms and informing precision prevention strategies.
	Abstract:	https://www.medrxiv.org/content/10.64898/2026.09.14.26363028v1
	Full Text:	https://www.medrxiv.org/content/10.64898/2026.09.14.26363028v1.full-text
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	Search Authors:	Anna Huynh Brady J Gaynor John W Cole Patrick McArdle Huichun Xu Christina Jern Guillaume Par Steven J Kittner Michael Chong Tara M Stanne Braxton D Mitchell,
AGING EXERCISE MUSIC
Mre37-014	Leader and Follower Roles in Adapted Tango Reveal Complementary Neural Routes to Motor Improvement in Parkinsons Disease
	Quote:	These findings indicate that adapted tango can improve motor outcomes in PD through complementary IG and EG movement-weighted mechanisms, with Leader training potentially supporting neural normalization and Follower training engaging distributed cue-to-action networks.
	Abstract:	https://www.medrxiv.org/content/10.64898/2026.09.14.26362964v1
	Full Text:	https://www.medrxiv.org/content/10.64898/2026.09.14.26362964v1 .full-text
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	Search Authors:	Constantina Theofanopoulou Neha Bajaj Alberto Munoz Sanchez Bruce Crosson Steven L Wolf Venkatagiri Krishnamurthy Keith McGregor Madeleine E. Hackney,
AGING BRAIN
Mre37-016	Intensive Home-Based Motor Imagery Neurofeedback Training Using Mobile EEG to Assess Changes in Brain Activity and Motor Function in Stroke Survivors: A Multiple Baseline Design (MINTS Study Protocol)
	Quote:	Background Motor imagery neurofeedback (MI-NF) engages sensorimotor brain networks and has shown potential for motor recovery after stroke.
	Abstract:	https://www.medrxiv.org/content/10.64898/2026.09.14.26363000v1
	Full Text:	https://www.medrxiv.org/content/10.64898/2026.09.14.26363000v1 .full-text
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	Search Authors:	Jennifer Decker Linda Christin Bergmann Stephanie Rosemann Andreas Hein Cornelia Kranczioch,
AGING BRAIN
Sd372-008	Scientists Discover a Major Brain Shift Between Ages 50 and 75
	Quote:	Scientists have uncovered sweeping changes in how the human brain controls and organizes its genome beginning in midlife, offering new clues to why aging sharply increases the risk of Alzheimers and other neurodegenerative diseases. One of the biggest shifts occurred between about ages 50 and 75, when many of the brains original immune cells declined and were replaced by cells with more inflammatory characteristics. Researchers also found weakening of cells that help maintain the blood-brain barrier, along with widespread deterioration in the genomes three-dimensional organization.
	Article:	https://www.sciencedaily.com//releases/2026/09/260914102441.htm
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PRIME AGING CANCER NUTRITION
Sd372-016	Cancer Is Rising in Younger Adults. Faster Biological Aging May Help Explain Why
	Quote:	Cancer rates are rising in adults under 55, and new research suggests accelerated biological aging may be one piece of the puzzle. Scientists found that people from more recent generations tended to have bodies that appeared biologically older than those of earlier generations at the same chronological age. Greater biological age acceleration was linked to a higher risk of early onset cancers, with specific patterns seen for lung, gastrointestinal, uterine and colorectal cancers.
	Comment:	We eat more processed foods than the older generation did.
	Article:	https://www.sciencedaily.com//releases/2026/09/260913082200.htm
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AGING
Sd372-026	Scientists Find How Zombie Cells Fuel Inflammation as We Age
	Quote:	Scientists discovered that aging cells can use malfunctioning mitochondria to unlock inflammatory genes and keep the immune system stuck in a prolonged state of alert. Blocking one part of this process reduced inflammation and improved healthy aging
	Article:	https://www.sciencedaily.com//releases/2026/09/260911214301.htm
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AGING BRAIN COGNITION
Sd375-001	Scientists Restore a Brain Protein and Reverse Signs of Aging in Mice
	Quote:	Scientists found that declining levels of the brain protein Menin may help drive aging, with lower levels in mice linked to inflammation, cognitive decline, weaker bones, and thinner skin. Restoring Menin reversed several age-related changes, while the amino acid D-serine improved cognition, hinting at a potentially intriguing new target for healthy aging.
	Article:	https://www.sciencedaily.com//releases/2026/09/260918000437.htm
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Javilk's Research Links Newsletter for Week 37
Updated 09/19/2026-02:54:36 AM
What interests you? What have you found? Tell me!
Drop me a note at Javilk.com to subscribe or submit something.

Ad372-004

Scientists Reversed Biological Age in Older Adults in Just 4 Weeks

Ad372-040

Most Men Dont Know Dairy Is Linked to Prostate Cancer Risk

Mge37-022

Lysosomal polygenic risk score in Parkinsons disease across populations.

Mgr37-002

Feasibility, Safety, and Preliminary Efficacy of Partnered Rhythmic Rehabilitation in Prodromal Alzheimers Disease: A 12-Month Pilot Randomized Controlled Trial

Mne37-002

GFAP as a Biomarker of Stroke Subtype and Brain Tissue Damage in Acute Stroke: A Systematic Review and Meta-Analysis

Mne37-007

Sex and Life Stage Differences in the Association Between Cognitive Engagement and Cognitive Change

Mne37-013

Antihypertensive Medication Class and Incident Alzheimers Disease and Related Dementias: External Replication Across Two Independent Healthcare Data Sources-the Vanderbilt EHR Synthetic Derivative and US Medicare Claims

Mne37-015

Accelerometer-Derived Relative Amplitude and Midlife Cognition: A Cross-Sectional Study

Mne37-019

Sex-Specific Associations of Carotid Plaque Calcification Subtypes with Stroke, TIA, and Retinal Ischemia

Mne37-022

Identification of Plasma Protein Biomarkers for Early-Onset Stroke through Mendelian Randomization

Mre37-014

Leader and Follower Roles in Adapted Tango Reveal Complementary Neural Routes to Motor Improvement in Parkinsons Disease

Mre37-016

Intensive Home-Based Motor Imagery Neurofeedback Training Using Mobile EEG to Assess Changes in Brain Activity and Motor Function in Stroke Survivors: A Multiple Baseline Design (MINTS Study Protocol)

Sd372-008

Scientists Discover a Major Brain Shift Between Ages 50 and 75

Sd372-016

Cancer Is Rising in Younger Adults. Faster Biological Aging May Help Explain Why

Sd372-026

Scientists Find How Zombie Cells Fuel Inflammation as We Age

Sd375-001

Scientists Restore a Brain Protein and Reverse Signs of Aging in Mice