PRIME CANCER
Aee38-1046	The Cancer Protocol Industry Giants Hope You Never Find
	Quote:	A recent observational study followed 197 cancer patients who added two common, off-patent drugs to their care: compounded ivermectin and mebendazole. The outcomes are staggering. Over 84 percent experienced measurable clinical benefit, with nearly half seeing actual tumor reduction or no remaining sign of disease. Side effects were minimal, and these generic compounds cost pennies compared to the brutal regimens being pushed in hospital wards every day.
	Article:	https://principia-scientific.com/the-cancer-protocol-industry-giants-hope-you-never-find/
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CANCER METABOLISM
Bbc38-008	Lysosomal acid lipase regulates cholesterol metabolism during phagosomal maturation
	Quote:	hese findings reveal that LIPA couples cholesterol metabolism to phagocytosis, defining a mechanistic link between lipid catabolism and antimicrobial defence. By positioning CE hydrolysis as a critical determinant of phagosomal dynamics, our work uncovers a metabolic checkpoint in innate immunity and identifies LIPA as a potential therapeutic node in infection and inflammation.
	Article:	https://www.biorxiv.org/content/10.64898/2026.09.18.752819v1
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	Search Authors:	Ojal Saharan Bhawna Bhawna Shakuntala S K Saraswati Abdul Akhir Sidharth Chopra Dhiraj Kumar Roop Mallik Siddhesh Kamat,
CANCER DRUGS
Sd383-012	This New Drug Could Break Cancers Resistance to Treatment
	Quote:	"Of all the biological switches on TopBP1, switch BRCT7/8 interacts with several key regulators of cancer growth, including MIZ1, a suppressor of cancer driver MYC; mutant p53, which can acquire cancer-promoting functions; and PLK1 and CIP2A, proteins that help cancer cells survive and divide," said Lin, a member of Baylors Dan L Duncan Comprehensive Cancer Center. "All together, these diverse roles position TopBP1-BRCT7/8 as a promising target for intervention."
	Article:	https://www.sciencedaily.com//releases/2026/09/260921081112.htm
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CANCER
Sd384-004	Scientists Discover an Impossible Cellular Survival Pathway That Could Help Fight Cancer
	Quote:	Scientists discovered a surprising backup system that lets mammalian cells make the essential amino acid cysteine even when the pathways once considered indispensable are disabled. The same survival mechanism may help cancer cells resist treatment, raising the possibility that shutting it down could make tumors easier to kill.
	Article:	https://www.sciencedaily.com//releases/2026/09/260923035939.htm
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CANCER
Sd384-008	Scientists Thought They Knew How This 70-year-old Leukemia Drug Worked
	Quote:	For more than seven decades, doctors have used the drug 6-thioguanine (6-TG) to treat leukemia. Its effects in patients are well documented, but researchers are still working to understand the molecular details that determine why some cells are killed by the drug while others manage to withstand it.
	Article:	https://www.sciencedaily.com//releases/2026/09/260923035932.htm
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Javilk's Research Links Newsletter for Week 38
Updated 09/26/2026-01:19:25 AM
What interests you? What have you found? Tell me!
Drop me a note at Javilk.com to subscribe or submit something.

Aee38-1046

The Cancer Protocol Industry Giants Hope You Never Find

Bbc38-008

Lysosomal acid lipase regulates cholesterol metabolism during phagosomal maturation

Sd383-012

This New Drug Could Break Cancers Resistance to Treatment

Sd384-004

Scientists Discover an Impossible Cellular Survival Pathway That Could Help Fight Cancer

Sd384-008

Scientists Thought They Knew How This 70-year-old Leukemia Drug Worked