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    PRIME    PRIO    BRAIN    COGNITION    NUTRITION   

Aae39-1014

Citicoline: A Promising Nutrient for Brain Health and Cognition

Quote: Citicoline (also known as CDP-choline) is a substance made in our bodies from a nutrient called choline. Choline is a nutrient in the B complex family found in whole milk, beef liver, eggs, soy foods, peanuts and cruciferous vegetables like broccoli and Brussels sprouts. There is interest in taking citicoline for various conditions that affect the brain, and it has been studied for improving memory and thinking skills. Citicoline is effective in preventing and slowing down dementia Researchers systematically reviewed studies on the effect of citicoline on cognitive performance. They selected seven studies including patients with mild cognitive impairment, Alzheimers disease or post-stroke dementia. All the studies showed a positive effect of citicoline on cognitive functions.
Article: https://richardgoldberg.substack.com/p/citicoline-a-promising-nutrient-for
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    PRIME    PRIO    AGING    HEART   

Aef39-1006

Old hearts age backwards: transplanted organs adjust to hosts biological age

Quote: What happens to organs when they are transplanted? Hearts from young donors age rapidly in the bodies of older recipients, and older hearts are rejuvenated inside young people, according to a study1. The findings, posted on the preprint server bioRxiv and not yet peer reviewed, imply that replacement organs could be sourced from older people than they are at present....

"The remarkable thing is that we found exactly the same effects that we saw in the mice," says Poganik. The transplanted hearts had taken on the biological ages of their new hosts.

Article: https://www.nature.com/articles/d41586-026-03043-w
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See Also:
  • https://pubmed.ncbi.nlm.nih.gov/37500973/
  •     PRIME    PRIO    AGING    HEART   

    Aef39-1007

    Multi-omic rejuvenation and life span extension on exposure to youthful circulation

    Quote: Remarkably, this rejuvenation effect persisted even after 2 months of detachment. Transcriptomic and epigenomic profiles of anastomosed mice showed an intermediate phenotype between old and young, suggesting a global multi-omic rejuvenation effect. In addition, old HPB mice showed gene expression changes opposite to aging but akin to several life span-extending interventions. Altogether, we reveal that long-term HPB results in lasting epigenetic and transcriptome remodeling, culminating in the extension of life span and health span.
    Article: https://pubmed.ncbi.nlm.nih.gov/37500973/
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        PRIME    PRIO   

    Nih392-006

    Scientists identify new role for tau protein in brain diseases

    Quote: They also found that phosphorylated tau entered mitochondria in mouse brains. There, phosphorylated tau interacted with a part of the electron transport chain. This changed interactions among mitochondrial proteins and activated reverse electron transport. Stress alone failed to induce this activation in mice and flies lacking tau. Elevated reverse electron transport also drove hyperphosphorylation, creating a harmful feedback loop. In an attempt to interrupt that loop, researchers used a specific compound to inhibit reverse electron transport.
    Article: https://nih.gov//news-events/nih-research-matters/scientists-identify-new-role-tau-protein-brain-diseases
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        PRIME    PRIO    EYES   

    Sd392-004

    Forget LASIK: Safer, Cheaper Vision Correction Without Lasers or Incisions

    Quote: Scientists are developing a possible alternative to LASIK that reshapes the cornea without cutting it or using a laser. The technique uses a small electric potential and a specially shaped platinum lens to temporarily soften the cornea, allowing it to be molded in about a minute.
    Comment: LASIK weakens the eyes, resulting in loss of sharpness when mountain climbing, and has risks. This, it appears, can be redone multiple times to deal with vision changes as one ages.
    Article: https://www.sciencedaily.com//releases/2026/09/260927034004.htm
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      Javilk's Research Links Newsletter for Week 39
    Updated 10/03/2026-03:08:04 AM
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