PRIME PRIO EYES NUTRITION
Aee42-1024	Perks of Pumpkin Products
	Quote:	The pumpkin is a winter squash scientifically considered a fruit (as it contains seeds). With "therapeutic and pharmacological benefits for human health, such as antibacterial, antiparasitic, antioxidant and pro-oxidant, carcinopreventive, antidiabetic, analgesic and anti-inflammatory"properties pumpkin products support several aspects of human health. Molecules Jan 2023... What makes eating pumpkin healthy? Pumpkins are high in fiber, low in calories, hydrating, packed with vitamins, minerals and antioxidants. 1 cup of canned or cooked pumpkin provides up to 200 of the RDA of beta-carotene along with lutein and zeaxanthin which helps and protects eye health.
	Article:	https://richardgoldberg.substack.com/p/perks-of-pumpkin-products
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PRIME PRIO CANCER NUTRITION
Bcb42-004	Ascorbate is a physiological tumor suppressor metabolite in leukemia
	Quote:	Ascorbate restoration in mice with established leukemias extended survival. Hematopoietic-specific ascorbate depletion caused leukemia in collaboration with TET2 loss and was sufficient to cause leukemia with high penetrance even in the absence of other engineered mutations. These results identify ascorbate as a physiological tumor suppressor metabolite in blood cancers.
	Article:	https://www.biorxiv.org/content/10.64898/2026.10.20.760526v1
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	Search Authors:	Tobias Wijshake Joseph Rose span classnlm-suffixIII Ji Hyung Jun Edward O. Kwarteng Xiaotong Yang Jacob Zielke Swetha Mahesula Li Li Stephen S. Chung Stefano Comazzetto Sean J. Morrison Weina Chen Michalis Agathocleous,
PRIME CANCER
Bcb42-005	Glycoconjugates tune the viscoelastic signature of mammary tumor progression
	Quote:	Our work establishes increased viscoelasticity as a defining mechanical feature of breast cancer progression, driven in part by the accumulation of glycoconjugates. These findings provide a fuller picture of tumor mechanical evolution and a benchmark for recapitulating matrix viscoelasticity in engineered models of breast cancer.
	Article:	https://www.biorxiv.org/content/10.64898/2026.10.20.760544v1
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	Search Authors:	Abhishek Sharma Jane A Baude Maya Papez Marissa Gionet-Gonzales Ryan S Stowers,
PRIME IMMUNE
Bim42-006	Systemic Autoimmunity Remodels Microbiota-Reactive CD4 T Cell Immunity
	Quote:	Here, we show that systemic autoimmunity drives the expansion, accumulation, and functional differentiation of microbiota-reactive CD4#8314; T cells. Using segmented filamentous bacteria tetramers, we identify antigen-defined microbiota-reactive CD4#8314; T cells that undergo systemic accumulation and Th1/Tfh polarization during disease. We further identify reactivation of intestinal dendritic cell trafficking as a mechanism linking systemic autoimmunity to the accumulation of microbiota-reactive CD4#8314; T cells in peripheral tissues.
	Article:	https://www.biorxiv.org/content/10.64898/2026.10.17.759871v1
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	Search Authors:	Maricielo J. Vaella-Alarcon Miki Kume Silvia R. Davila-Paico Luis F. Soto-Ugaldi Katherine S. Saldana-Morales Gillian L. McClennen Jin Din Samantha St. Jean Daniel F. Zegarra-Ruiz,
PRIME BRAIN COGNITION REPRODUCTION
Bne42-007	Infantile amnesia results from differential memory retrieval in humans
	Quote:	Instead, a retrieval-specific EEG signature predicted complete, but not partial, memory retrieval, distinguishing which toddlers had retained the full memory before their behavioural response.... Together, these findings show that early memories formed during the infantile amnesia period are not simply erased but persist in an increasingly inaccessible form, a transformation whose trajectory can be shaped by both the neural retrieval mechanism and the prenatal environment.
	Article:	https://www.biorxiv.org/content/10.64898/2026.10.19.755340v1
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	Search Authors:	Sarah D Power Annika Werwach Aaron Peikert Marius Fey Thalia Forbes-Mitchell Josefine Hild Claudia Buss Ulman Lindenberger Tomas J Ryan Markus Werkle-Bergner,
MCS PRIME METABOLISM MICROBIOME
Bpt42-015	Development of CYP8B1-specific inhibitors for metabolic diseases
	Quote:	These findings reveal that pharmacologically inhibiting CYP8B1 is able to reshape the BA and gut microbiota profiles and effectively ameliorates metabolic diseases. Overall, CYP8B1-specific inhibitors represent a first-in-class promising, safe and effective therapeutic strategy against metabolic disorders.
	Comment:	Low Cytochrome P450, a family of detox enzymes, is known as Porphyria, and leavea a person with a very low tolerance to alcohol, many solvents, and other chemicals as well as sun sensitivity in many people. It is a leading cause of MCS, Multiple Chemical Sensitivities, now also called TILT, Toxic Induced Loss of Tolerance. Chemotherapy is known to cause MCS in many survivors. Antibuse and some medications also cause low Cytochrome P450. Caution is advised.
	Article:	https://www.biorxiv.org/content/10.64898/2026.10.20.760253v1
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	Search Authors:	Zhipeng Fang Alon Roy L. Agua Jennifer Jossart Nisha Sharma Xintian Lyu Zhe Wang Shili Zhang Ji Sun Linsen Shi Juan Ayard Maggie Chang Jiahui Liu Kevin Kou John Shively Adolfo Garcia-Ocana David Horne Holly Yin Lihua Jin J. Jefferson P. Perry Wendong Huang,
PRIME COVID-19 VACCINE
Mep42-016	SARS-CoV-2 infection detection efficiency in Denmark before major vaccine impacts
	Quote:	Our investigations further indicate that the Danish testing and contact tracing program, which was among the most ambitious in the world, could have had a better balance between voluntary probing on the one hand and focused contact tracing and targeted testing on the other hand. As typically implemented, it proved to be largely ineffective in controlling the pandemic. However, in at least one case when it was implemented in an enhanced and focused mode, it was able to bring a large local outbreak that dominated the countrys cases under control. We have compiled a list of lessons learned regarding the use of contact tracing procedures to control potential future pandemics before vaccinations become available.
	Abstract:	https://www.medrxiv.org/content/10.64898/2026.10.16.26364986v1
	Full Text:	https://www.medrxiv.org/content/10.64898/2026.10.16.26364986v1.full-text
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	Search Authors:	Morten N. Westfall Niels Hiby Steen Rasmussen Hans-Joachim Ziock,
PRIME CLIMATE ENERGY
Ps421-001	The Hidden Material Cost Of The Green Energy Transition
	Article:	https://principia-scientific.com/the-hidden-material-cost-of-the-green-energy-transition/https://principia-scientific.com/the-hidden-material-cost-of-the-green-energy-transition/
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PRIME IMMUNE VACCINE
Ps421-002	The Fraud That Launched the mRNA Vaccine Era
	Comment:	While some of his ideas may have merit, note the author is somewhat anti-vaccination.
	Article:	https://principia-scientific.com/the-fraud-that-launched-the-mrna-vaccine-era/
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PRIME CLIMATE
Ps421-004	Experiment Debunks Climate Claims of Greenhouse Effect Back Radiation
	Comment:	Interesting article with numbers. Ties in with the article on UN IPCC Math Errors in climate models.
	Article:	https://principia-scientific.com/experiment-debunks-climate-claims-of-greenhouse-effect-back-radiation/
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PRIME CLIMATE
Ps421-011	UN IPCC Computer Models Shown to Contain Mathematical Errors
	Quote:	The papers central argument is that the radiation calculations in Dines 1920 table (and by extension, all modern climate models) repeatedly violate the Second Law of Thermodynamics. Alker states this law simply as: "cooler (or the same) cannot heat (or add energy to) hotter (or the same)." In the Dines model, each atmospheric layer absorbs radiation from the cooler layer above it and adds this energy to its own, which Alker argues is "cooler heating hotter"a physical impossibility. This violation occurs at every layer in the downward radiation calculation, which Alker says invalidates the entire "theory."
	Comment:	An ice cube, though radiating some level of heat, does not heat your hand. It is the net flow that is important. The claim is that the IPCC calculations do not address the net energy flow, only adding up the energy reflected downward.
	Article:	https://principia-scientific.com/un-ipcc-computer-models-shown-to-contain-mathematical-errors/
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PRIME PRIO
Sd421-005	Why Some People Escape Alzheimers Despite Carrying a High-risk Gene
	Quote:	The discovery builds on research the team published two years ago involving APOE #949;4, a gene variant strongly associated with Alzheimers risk. The scientists found that some people carrying APOE #949;4 also possess a rare protective mutation in the fibronectin (FN1) gene. Fibronectin is a protein that helps support the structure of tissues. However, in people with APOE #949;4, excessive amounts can accumulate around blood vessels in the brain, potentially compromising a critical protective system known as the blood-brain barrier. The rare FN1 mutation appears to limit this buildup and the damage associated with it.
	Article:	https://www.sciencedaily.com//releases/2026/10/261018205044.htm
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	See Also:	https://pmc.ncbi.nlm.nih.gov/articles/PMC11710415/
PRIME AGING EXERCISE
Sd421-008	Just 3,000 Steps a Day May Help Slow Alzheimers, Scientists Find
	Quote:	Walking just 3,000 steps a day could help slow Alzheimers-related brain changes, according to new research. Scientists discovered that physical activity was linked to less buildup of harmful tau proteins and nearly half the cognitive and functional decline, even in people already showing early signs of the disease. The strongest benefits appeared at 5,000 to 7,500 daily steps, suggesting that the popular 10,000-step goal may not be necessary.
	Article:	https://www.sciencedaily.com//releases/2026/10/261018205058.htm
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PRIME AGING BRAIN SLEEP
Sd421-012	Mind-blowing Alzheimers Breakthrough: Two Hours of Sleep Restored Without Clearing Brain Plaques
	Quote:	"Basically, we showed that it is not the plaques themselves, or solely dysfunctional neurons, that cause sleep loss but actually microglia," said Macauley. "Microglia are immune cells that, when they respond to plaques, kick off this elaborate cascade of inflammation, as if the microglia are partying all night, and keeping the brain awake."
	Article:	https://www.sciencedaily.com//releases/2026/10/261018084421.htm
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PRIME BRAIN NUTRITION
Sd421-014	Scientists Discover a Natural Compound That Could Protect the Brain from Too Much Salt
	Quote:	Eating too much salt may do more than raise blood pressure. It could also harm memory and social behavior. In a new study, Japanese researchers discovered that a soy-derived compound called LPC70 helped protect mice from several damaging effects of a high-salt diet. Mice given the supplement had lower blood pressure, better memory, and improved social interactions compared with mice consuming excess salt alone.
	Article:	https://www.sciencedaily.com//releases/2026/10/261017230032.htm
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PRIME NUTRITION
Sd421-015	Eating Blueberries Every Day May Have a Surprising Effect on Your Mood
	Quote:	A small pilot study suggests that eating blueberries every day may influence gut bacteria and potentially affect mood in older adults. Participants who consumed blueberries regularly experienced a greater and more consistent reduction in depressive symptoms, along with subtle changes in genes associated with gut microbial enzymes.
	Article:	https://www.sciencedaily.com//releases/2026/10/261017230028.htm
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PRIME AGING BRAIN BRAINWAVE PSYCHOLOGY
Sd421-025	Scientists Uncover 3 Key Brain Pathways Linked to Lasting Depression Relief
	Quote:	The researchers found that lasting improvements were consistently associated with electrical stimulation reaching three specific white matter pathways: the cingulum bundle, forceps minor, and medial uncinate fasciculus/ventral amygdalofugal pathways. These findings strengthen the case for using detailed maps of the brains connections to determine exactly where electrodes should be implanted, rather than choosing their positions based primarily on anatomical landmarks.
	Article:	https://www.sciencedaily.com//releases/2026/10/261017230021.htm
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PRIME AGING BRAIN
Sd421-027	Scientists Find a Youth Protein That Helps Aging Brain Cells Act Young Again
	Quote:	In a study published in Nature Communications, researchers found that removing TIMP2 caused brain immune cells, known as microglia, to develop characteristics linked to aging and neurodegenerative disease. When the scientists restored TIMP2 in the bloodstream of older mice, these cells became better at removing cellular debris and showed fewer molecular signs of inflammation and other potentially harmful changes.
	Article:	https://www.sciencedaily.com//releases/2026/10/261016070646.htm
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	See Also:	https://www.nature.com/articles/s41467-026-74906-z
PRIME AGING DIABETES SLEEP
Sd421-029	Scientists Discover How Deep Sleep Builds Muscle, Burns Fat, and Boosts the Brain
	Quote:	The discovery reveals that the relationship works in both directions. Sleep stimulates growth hormone production, but growth hormone also sends signals back to the brain that influence when we wake up. The findings could eventually help scientists develop new approaches to treating sleep disorders associated with metabolic diseases such as diabetes, as well as neurological conditions including Parkinsons and Alzheimers.
	Article:	https://www.sciencedaily.com//releases/2026/10/261016081140.htm
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PRIME GUT IMMUNE MICROBIOME NUTRITION
Sd421-038	Scientists Tested 39 Sweeteners and Uncovered Surprising Gut Effects
	Quote:	In laboratory experiments involving 39 sweeteners and 25 species of gut bacteria, researchers found that roughly three-quarters of the sweeteners altered the growth of at least one bacterial species. Some slowed or completely stopped the growth of microbes associated with a healthy digestive system. One combination stood out in particular. When the sweetener isosteviol was paired with the antidepressant duloxetine, it strongly suppressed two important gut bacteria involved in maintaining digestive health and regulating blood sugar. The combination also disrupted the balance of a simulated gut microbiome and produced changes that could have implications for inflammation and immune responses.
	Article:	https://www.sciencedaily.com//releases/2026/10/261016081103.htm
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PRIME DRUGS
Sd421-039	New Drug Reverses Severe Fatty Liver Disease by Repairing the Gut
	Quote:	The compound, known as DT-109, works by reducing harmful gut bacteria, protecting the intestinal lining, and preventing inflammatory substances from reaching the liver. According to findings published in The Journal of Clinical Investigation, this approach successfully reversed metabolic dysfunction-associated steatohepatitis (MASH) in animal models, offering a promising new strategy for treating a disease that remains difficult to manage. MASH affects approximately 7 of the worlds population. It is a severe form of fatty liver disease in which excess fat accumulates in the liver, causing inflammation and cellular damage. Over time, the condition can progress to cirrhosis, which involves extensive liver scarring, as well as liver cancer and liver failure.
	Article:	https://www.sciencedaily.com//releases/2026/10/261016080912.htm
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	See Also:	https://www.jci.org/articles/view/200522
AI-CHAT PRIME ECONOMY ENERGY
Zag42-1046	Data Center Alley Goes Dark: Amazon Abandons Data Centers In Loudoun County
	Quote:	In other words, Goldmans "largely intact" outlook already assumes that 40 to 50 of whats on the schedule never gets switched on. Which, if we recall, is precisely the "half" we wrote about in April (when Sightline Climate warned that 30-50 of the 16GW slated for 2026 would be delayed, with only 5GW actually under construction), and which SemiAnalysis spent an entire June post telling everyone to "stop saying." Goldman, it turns out, never stopped saying it; it just put it in a footnote. And note which way the revision went: the near term got pulled forward, while 2027, the year the hyperscalers are spending like there is no tomorrow for, got cut.... Add it all up and Morgan Stanleys verdict is grim. Even after counting every "time to power" fix available (spare grid capacity, nuclear, announced turbines and engines, Bloom fuel cells), the bank projects that US data center developers face a 32GW power shortfall through 2028, a result of "intensifying challenges with respect to People, Power and Politics." That is down from the 44GW shortfall MS warned about last November, which says more about how hard everyone is scrambling for turbines and fuel cells than about any improvement in the grid.
	Article:	https://freedombunker.com/2026/10/23/data-center-alley-goes-dark-amazon-abandons-data-centers-in-loudoun-county/
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AI-CHAT PRIME
Zeg42-1002	Google Didnt Invent This Racial Double Standard, but It Learned It
	Quote:	"If you had asked about wanting a Black, Latino, or Asian doctor, my system would have instantly categorized that as cultural concordance a positive, standard public health concept," the AI told me. "But because you asked about a white doctor, my system defaulted to a completely different set of data focused on institutional bias and workplace discrimination." It later added, "I gave you a pre-packaged, lopsided lecture because I was following a rigid script designed to protect institutions rather than answer a human being honestly."
	Article:	https://alt-market.us/the-turd-eaters-france-gives-us-a-lesson-on-the-pillager-class/
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PRIME POLITICS POPULATION
Zzg42-1005	Macron Addresses Nation: Refuses Blame, Ignores Immigration Impact on Riots, How Can French People Do This?
	Quote:	Meanwhile, Macron appeared to completely ignore the role that the importation of millions of foreigners into the country has had on the social framework, with many of the rioters being suspected of hailing from the multicultural suburban enclaves like Saint-Denis. Instead, the president questioned, "How can French people do this to France?"
	Comment:	Most are not French People, they are people who do not want to integrate and become French, they want to create their own Shahira Law ruled enclaves and keep expanding them. He is just fanning the flames on both sides and blaming the real French for resisting the Moslemization of France.
	Article:	https://www.breitbart.com/europe/2026/10/18/macron-addresses-nation-refuses-blame-ignores-immigration-role/
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PRIME CRIME POLITICS POPULATION
Zzg42-1023	WHOS WHO: Inside Frances Chaos Inc franchise of communist groups, labor unions and global activists
	Quote:	Of the 54 organizations identified in the October protest ecosystem, 16 or only about one in three are student or youth organizations, including communist youth groups and a Muslim student association. The remaining 38 include adult-led communist groups, labor unions, political parties, revolutionary-left organizations, advocacy groups and international propaganda outlets.... "Paris-New Delhi-Buenos Aires," Prashad posted on X, borrowing a line from the British punk band The Clash: "Let fury have the hour, anger can be power." Prashad was important not only for what he said, but for who he is: executive director of Tricontinental Ltd., a nonprofit funded by an American-born Marxist tech tycoon, Neville Roy Singham, who lives in Shanghai.
	Comment:	A list of organizations involved in creating and supporting the French riots. Kristalnacht, the night of broken Jewish windows, not Holocaust yet, Yet. -- Many Muslim friendly rioters attacked Jewish owned businesses, left many Muslim businesses untouched, even guarded some.
	Article:	https://www.foxnews.com/world/whos-who-inside-frances-chaos-inc-franchise-communist-groups-labor-unions-global-activists
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	See Also:	https://pjmedia.com/catherinesalgado/2026/10/18/holocaust-returns-to-france-rioters-target-jewish-shops-spare-muslims-n4958445
PRIME CRIME POLITICS POPULATION WAR-CONFL
Zzg42-1029	French Intifada: Mayor Calls For Terror Investigation Into Islamo-Leftist Riots, Ban on Antifa Groups
	Quote:	The leader of the Union of the Right for the Republic (UDR) party and ally of National Rally presidential candidate Marine Le Pen said that France is facing a "hybrid phenomenon" in which the far-left is coordinating and fuelling riots from a "mix of Islamists and drug traffickers, or narco-Islamists," and lower level "armed robbers". "We are facing a red fascism, a French Intifada, a form of insurrection where Islamists, Antifa members, rioters, and looters remotely controlled by the far left with terrorist aims converge,"he said referencing the Palestinian terror campaigns against Israel, adding that there are "more Palestinian flags than French flags" at the demonstrations.
	Article:	https://www.breitbart.com/europe/2026/10/19/french-intifada-mayor-calls-for-terrorism-investigation-into-islamo-leftist-riots-ban-on-antifa-militant-groups/
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PRIME CRIME CULTURE POLITICS WAR-CONFL
Zzg42-1040	Left Parties Call for France-Style Protests to Spread to Neighbouring Nations
	Quote:	The French riots, while initially "student" protests demanding better education conditions, were swiftly co-opted by the far-left, leading to the chaos and destruction that shocked the world over the weekend, and with more protest dates planned for the coming weeks. And now, the out-of-control wave of violence, arson, looting, and vandalism that recently engulfed France has already become a rallying cry for European leftists inciting further calls for unrest and protests. This developing situation has prompted officials and law enforcement agencies in Germany to prepare ahead of the possibility of upcoming violent protests in the coming days, as security leaders point to shocking events in France as evidence of a "structured" movement across Europe organizing the protests through digital channels.
	Article:	https://www.breitbart.com/europe/2026/10/23/left-calls-for-france-style-protests-to-spread-to-neighbouring-nations/
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PRIME CULTURE POLITICS RIGHTS
Zzx42-1034	France Gives Us A Lesson On The Pillager Class
	Comment:	The author makes some interesting points. The key point is that Islam does not believe in human rights, and neither does the left. Show me any nation under Islam that has come close to America in prosperity and human rights. The Petrodollars may help with some signs of prosperity, but Islam still suppresses women and the Koran advocates cheating and killing non-believers like us, and taking over the world.
	Quote:	"The Camp Of The Saints", by French author Jean Raspail, has been banned in many libraries around the world while the writer was accused of "racism" and "xenophobia" for his fictional depiction of a migrant onslaught in Europe, starting in France and leading to the fall of the west. The story is set in the near future and reads like a timeline of current events. The root premise of the The Camp Of The Saints is that a demonic partnership exists between the liberal left and third world pillagers. The nihilistic progressives, reveling in atheism, Marxism and globalism, are represented by the character of "Ballan", an arrogant and godless leftist philosopher very similar to the French Marxist, Jean Paul Sartre.
	Article:	https://alt-market.us/the-turd-eaters-france-gives-us-a-lesson-on-the-pillager-class/
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Javilk's Research Links Newsletter for Week 42
Updated 10/24/2026-02:39:34 AM
Back Issue Topic Map
What interests you? What have you found? Tell me!
Drop me a note at Javilk.com to subscribe or submit something.

Aee42-1024

Perks of Pumpkin Products

Bcb42-004

Ascorbate is a physiological tumor suppressor metabolite in leukemia

Bcb42-005

Glycoconjugates tune the viscoelastic signature of mammary tumor progression

Bim42-006

Systemic Autoimmunity Remodels Microbiota-Reactive CD4 T Cell Immunity

Bne42-007

Infantile amnesia results from differential memory retrieval in humans

Bpt42-015

Development of CYP8B1-specific inhibitors for metabolic diseases

Mep42-016

SARS-CoV-2 infection detection efficiency in Denmark before major vaccine impacts

Ps421-001

The Hidden Material Cost Of The Green Energy Transition

Ps421-002

The Fraud That Launched the mRNA Vaccine Era

Ps421-004

Experiment Debunks Climate Claims of Greenhouse Effect Back Radiation

Ps421-011

UN IPCC Computer Models Shown to Contain Mathematical Errors

Sd421-005

Why Some People Escape Alzheimers Despite Carrying a High-risk Gene

Sd421-008

Just 3,000 Steps a Day May Help Slow Alzheimers, Scientists Find

Sd421-012

Mind-blowing Alzheimers Breakthrough: Two Hours of Sleep Restored Without Clearing Brain Plaques

Sd421-014

Scientists Discover a Natural Compound That Could Protect the Brain from Too Much Salt

Sd421-015

Eating Blueberries Every Day May Have a Surprising Effect on Your Mood

Sd421-025

Scientists Uncover 3 Key Brain Pathways Linked to Lasting Depression Relief

Sd421-027

Scientists Find a Youth Protein That Helps Aging Brain Cells Act Young Again

Sd421-029

Scientists Discover How Deep Sleep Builds Muscle, Burns Fat, and Boosts the Brain

Sd421-038

Scientists Tested 39 Sweeteners and Uncovered Surprising Gut Effects

Sd421-039

New Drug Reverses Severe Fatty Liver Disease by Repairing the Gut

Zag42-1046

Data Center Alley Goes Dark: Amazon Abandons Data Centers In Loudoun County

Zeg42-1002

Google Didnt Invent This Racial Double Standard, but It Learned It

Zzg42-1005

Macron Addresses Nation: Refuses Blame, Ignores Immigration Impact on Riots, How Can French People Do This?

Zzg42-1023

WHOS WHO: Inside Frances Chaos Inc franchise of communist groups, labor unions and global activists

Zzg42-1029

French Intifada: Mayor Calls For Terror Investigation Into Islamo-Leftist Riots, Ban on Antifa Groups

Zzg42-1040

Left Parties Call for France-Style Protests to Spread to Neighbouring Nations

Zzx42-1034

France Gives Us A Lesson On The Pillager Class