| Research Topics: |
| INDEX |
| AI-chat 3 |
| MCS 1 |
| PRIME 28 |
| PRIO 3 |
| aging 7 |
| brain 9 |
| brainwave 1 |
| cancer 8 |
| climate 3 |
| cognition 4 |
| covid-19 2 |
| crime 5 |
| culture 3 |
| dental 1 |
| diabetes 3 |
| drugs 2 |
| economy 2 |
| energy 3 |
| exercise 1 |
| eyes 5 |
| gender 1 |
| genetics 5 |
| gut 1 |
| heart 2 |
| immune 5 |
| language 1 |
| metabolism 1 |
| microbiome 2 |
| nutrition 5 |
| obesity 1 |
| pain 1 |
| physical 1 |
| politics 8 |
| population 6 |
| practice 1 |
| psychology 1 |
| quantum 1 |
| reproduction 1 |
| rights 1 |
| sleep 2 |
| tech 1 |
| vaccine 2 |
| war-confl |
| war-cyber 1 |
|
Scanned: 3298 Evaluated: 234 Selected: 59 Back Issue Map |
| AGING BRAIN | ||||||||||||||||||||||||||||||||||||||||||||||||||
Bne42-009 | Astrocytic sEH-EET signaling regulates microglial lysosomal function and suppresses the STING-Type I interferon pathway in Alzheimers disease | |||||||||||||||||||||||||||||||||||||||||||||||||
| Quote: |
Background: The development of #946;-amyloid (A#946;) pathology in
Alzheimers disease (AD) is accompanied by profound changes in
astrocytes and microglia and associated neuroinflammation. Soluble
epoxide hydrolase (sEH), which degrades anti-inflammatory
epoxyeicosatrienoic acids (EETs), is elevated in the AD brain, yet how
EETs restrain inflammation remains poorly understood....
Conclusion: We define an astrocyte-microglia axis in which astrocytic sEH limits EET availability and thereby sustains microglial STING signaling. By promoting lysosomal clearance of pSTING, EETs suppress type I IFN signaling and enhance microglial A#946; clearance, highlighting sEH inhibition as a therapeutic strategy targeting both neuroinflammation and lysosomal dysfunction in AD. | |||||||||||||||||||||||||||||||||||||||||||||||||
| Article: | https://www.biorxiv.org/content/10.64898/2026.10.16.759679v1 | |||||||||||||||||||||||||||||||||||||||||||||||||
| Search Similar: | Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho | |||||||||||||||||||||||||||||||||||||||||||||||||
| Search Authors: | Baijayanti Ghosh Shuo Wang Chuangye Qi Anamitra Ghosh Michele Comerota Chetan Singh Rajpurohit Darryl C. Zeldin Hui Zheng, | |||||||||||||||||||||||||||||||||||||||||||||||||
| AGING GENETICS | ||||||||||||||||||||||||||||||||||||||||||||||||||
Mep42-015 | Biological age measured by DNA methylation clocks and mortality: A systematic review and meta-analysis | |||||||||||||||||||||||||||||||||||||||||||||||||
| Quote: | Clocks incorporating additional surrogates and technical refinements showed numerically larger pooled associations than their original counterparts. GrimAge2 (HR per SD: 1.65 95 CI 1.53, 1.77 vs 1.46 1.38, 1.55) and PCGrimAge (1.56 1.36, 1.78 vs 1.51 1.32, 1.74) showed higher pooled HR association with all-cause mortality than GrimAge. Further work is warranted to evaluate the responsiveness of DNAm clocks to interventions and potential clinical utility. | |||||||||||||||||||||||||||||||||||||||||||||||||
| Abstract: | https://www.medrxiv.org/content/10.64898/2026.10.20.26365864v1 | |||||||||||||||||||||||||||||||||||||||||||||||||
| Full Text: | https://www.medrxiv.org/content/10.64898/2026.10.20.26365864v1.full-text | |||||||||||||||||||||||||||||||||||||||||||||||||
| Search Similar: | Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho | |||||||||||||||||||||||||||||||||||||||||||||||||
| Search Authors: | Jian Hua Tay Duarte Barros Jiajun Dong Shubham Choudhury Austeja Bakulaite Weilan Wang Andrea B. Maier, | |||||||||||||||||||||||||||||||||||||||||||||||||
| PRIME AGING EXERCISE | ||||||||||||||||||||||||||||||||||||||||||||||||||
Sd421-008 | Just 3,000 Steps a Day May Help Slow Alzheimers, Scientists Find | |||||||||||||||||||||||||||||||||||||||||||||||||
| Quote: | Walking just 3,000 steps a day could help slow Alzheimers-related brain changes, according to new research. Scientists discovered that physical activity was linked to less buildup of harmful tau proteins and nearly half the cognitive and functional decline, even in people already showing early signs of the disease. The strongest benefits appeared at 5,000 to 7,500 daily steps, suggesting that the popular 10,000-step goal may not be necessary. | |||||||||||||||||||||||||||||||||||||||||||||||||
| Article: | https://www.sciencedaily.com//releases/2026/10/261018205058.htm | |||||||||||||||||||||||||||||||||||||||||||||||||
| Search Similar: | Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho | |||||||||||||||||||||||||||||||||||||||||||||||||
| PRIME AGING BRAIN SLEEP | ||||||||||||||||||||||||||||||||||||||||||||||||||
Sd421-012 | Mind-blowing Alzheimers Breakthrough: Two Hours of Sleep Restored Without Clearing Brain Plaques | |||||||||||||||||||||||||||||||||||||||||||||||||
| Quote: | "Basically, we showed that it is not the plaques themselves, or solely dysfunctional neurons, that cause sleep loss but actually microglia," said Macauley. "Microglia are immune cells that, when they respond to plaques, kick off this elaborate cascade of inflammation, as if the microglia are partying all night, and keeping the brain awake." | |||||||||||||||||||||||||||||||||||||||||||||||||
| Article: | https://www.sciencedaily.com//releases/2026/10/261018084421.htm | |||||||||||||||||||||||||||||||||||||||||||||||||
| Search Similar: | Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho | |||||||||||||||||||||||||||||||||||||||||||||||||
| PRIME AGING BRAIN BRAINWAVE PSYCHOLOGY | ||||||||||||||||||||||||||||||||||||||||||||||||||
Sd421-025 | Scientists Uncover 3 Key Brain Pathways Linked to Lasting Depression Relief | |||||||||||||||||||||||||||||||||||||||||||||||||
| Quote: | The researchers found that lasting improvements were consistently associated with electrical stimulation reaching three specific white matter pathways: the cingulum bundle, forceps minor, and medial uncinate fasciculus/ventral amygdalofugal pathways. These findings strengthen the case for using detailed maps of the brains connections to determine exactly where electrodes should be implanted, rather than choosing their positions based primarily on anatomical landmarks. | |||||||||||||||||||||||||||||||||||||||||||||||||
| Article: | https://www.sciencedaily.com//releases/2026/10/261017230021.htm | |||||||||||||||||||||||||||||||||||||||||||||||||
| Search Similar: | Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho | |||||||||||||||||||||||||||||||||||||||||||||||||
| PRIME AGING BRAIN | ||||||||||||||||||||||||||||||||||||||||||||||||||
Sd421-027 | Scientists Find a Youth Protein That Helps Aging Brain Cells Act Young Again | |||||||||||||||||||||||||||||||||||||||||||||||||
| Quote: | In a study published in Nature Communications, researchers found that removing TIMP2 caused brain immune cells, known as microglia, to develop characteristics linked to aging and neurodegenerative disease. When the scientists restored TIMP2 in the bloodstream of older mice, these cells became better at removing cellular debris and showed fewer molecular signs of inflammation and other potentially harmful changes. | |||||||||||||||||||||||||||||||||||||||||||||||||
| Article: | https://www.sciencedaily.com//releases/2026/10/261016070646.htm | |||||||||||||||||||||||||||||||||||||||||||||||||
| Search Similar: | Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho | |||||||||||||||||||||||||||||||||||||||||||||||||
| See Also: |
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PRIME
AGING
DIABETES
SLEEP
| Sd421-029Scientists Discover How Deep Sleep Builds Muscle, Burns Fat, and Boosts the BrainQuote: |
The discovery reveals that the relationship works in both directions.
Sleep stimulates growth hormone production, but growth hormone also
sends signals back to the brain that influence when we wake up. The
findings could eventually help scientists develop new approaches to
treating sleep disorders associated with metabolic diseases such as
diabetes, as well as neurological conditions including Parkinsons and
Alzheimers.
| Article:
| https://www.sciencedaily.com//releases/2026/10/261016081140.htm | Search Similar: |
Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho | | ||||||||||||||||||||||||||||||||||||||||||
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Javilk's Research Links Newsletter for Week 42 Updated 10/24/2026-02:39:34 AM Back Issue Topic Map What interests you? What have you found? Tell me! Drop me a note at Javilk.com to subscribe or submit something. |