Research
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war-confl
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Scanned: 3298
Evaluated: 234
Selected: 59

 
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    BRAIN    EYES   

Bbe42-004

Why phosphenes are not always dots: modeling the shapes elicited 1 by intracortical stimulation of human V1

Quote: The majority of visual cortical prosthetic devices currently implanted in patients or under development rely on small depth electrodes. Reports from patients implanted with these devices suggest that stimulation with tiny electrodes does not reliably produce small punctate spots, with some patients reporting a variety of percepts, including larger spots and irregularly shaped phosphenes.
Article: https://www.biorxiv.org/content/10.64898/2026.10.18.759925v1
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Search Authors: Leili Soo Eirini Schoinas Geoffrey M Boynton Ione Fine Eduardo Fernndez, 
    BRAIN    EYES    IMMUNE   

Bim42-011

Innate Immune Dysregulation Precedes Clinical Onset in Neuromyelitis Optica

Quote: VirScan identified enhanced CMV-specific antibody reactivity following AQP4- IgG seroconversion, and network analyses revealed interactions between NMOSD-associated and CMV-derived proteins. Together, these findings establish a novel multi-hit model of NMOSD, with implications for understanding antibody-mediated autoimmunity more broadly.
Article: https://www.biorxiv.org/content/10.64898/2026.10.16.757427v1
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Search Authors: Leonie Muller-Jensen Debanjana Chakravarty Gianmarco Bellucci Yuan Ding Michelle Hughes Alejandro Mejia Garcia Carson E. Moseley Ravi Dandekar John W. Rose Lisa K. Peterson Ka-Ho Wong Bradley L. Demarest Noel Carlson David E. Horvat Keith Groshans Nathan Tagg Spencer R. Osbourn Sithembile L. Mabila Ruba Bou-Chahine Victor Wang M. Mateo Paz Soldan Sean J Pittock Bruce A. C. Cree Scott S. Zamvil Ari J. Green Adil Harroud Sergio E. Baranzini Michael R. Wilson Stacey L. Clardy Ahmed Abdelhak Tammy L. Smith, 
    BRAIN    COGNITION   

Bne42-003

Learned Audiovisual Predictability Modulates Depth-Resolved Hippocampal-Cortical Functional Coupling

Quote: Predictability-related connectivity changes showed a spatially structured pattern involving DG/CA3-pSTG and CA1-inferior frontal regions, with significant edge-wise effects resolved across cortical depths. These findings provide fine-grained evidence that learned auditory predictability modulates hippocampal-cortical functional interactions across temporo-frontal systems.
Article: https://www.biorxiv.org/content/10.64898/2026.10.17.759806v1
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Search Authors: Santa Sozzi Mahdi Enan Ryszard Auksztulewicz Caspar Schwiedrzik Lucia Melloni Fabrizio Esposito Nicola Vanello Federico De Martino, 
    PRIME    BRAIN    COGNITION    REPRODUCTION   

Bne42-007

Infantile amnesia results from differential memory retrieval in humans

Quote: Instead, a retrieval-specific EEG signature predicted complete, but not partial, memory retrieval, distinguishing which toddlers had retained the full memory before their behavioural response....

Together, these findings show that early memories formed during the infantile amnesia period are not simply erased but persist in an increasingly inaccessible form, a transformation whose trajectory can be shaped by both the neural retrieval mechanism and the prenatal environment.

Article: https://www.biorxiv.org/content/10.64898/2026.10.19.755340v1
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Search Authors: Sarah D Power Annika Werwach Aaron Peikert Marius Fey Thalia Forbes-Mitchell Josefine Hild Claudia Buss Ulman Lindenberger Tomas J Ryan Markus Werkle-Bergner, 
    AGING    BRAIN   

Bne42-009

Astrocytic sEH-EET signaling regulates microglial lysosomal function and suppresses the STING-Type I interferon pathway in Alzheimers disease

Quote: Background: The development of #946;-amyloid (A#946;) pathology in Alzheimers disease (AD) is accompanied by profound changes in astrocytes and microglia and associated neuroinflammation. Soluble epoxide hydrolase (sEH), which degrades anti-inflammatory epoxyeicosatrienoic acids (EETs), is elevated in the AD brain, yet how EETs restrain inflammation remains poorly understood....

Conclusion: We define an astrocyte-microglia axis in which astrocytic sEH limits EET availability and thereby sustains microglial STING signaling. By promoting lysosomal clearance of pSTING, EETs suppress type I IFN signaling and enhance microglial A#946; clearance, highlighting sEH inhibition as a therapeutic strategy targeting both neuroinflammation and lysosomal dysfunction in AD.

Article: https://www.biorxiv.org/content/10.64898/2026.10.16.759679v1
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Search Authors: Baijayanti Ghosh Shuo Wang Chuangye Qi Anamitra Ghosh Michele Comerota Chetan Singh Rajpurohit Darryl C. Zeldin Hui Zheng, 
    PRIME    AGING    BRAIN    SLEEP   

Sd421-012

Mind-blowing Alzheimers Breakthrough: Two Hours of Sleep Restored Without Clearing Brain Plaques

Quote: "Basically, we showed that it is not the plaques themselves, or solely dysfunctional neurons, that cause sleep loss but actually microglia," said Macauley. "Microglia are immune cells that, when they respond to plaques, kick off this elaborate cascade of inflammation, as if the microglia are partying all night, and keeping the brain awake."
Article: https://www.sciencedaily.com//releases/2026/10/261018084421.htm
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    PRIME    BRAIN    NUTRITION   

Sd421-014

Scientists Discover a Natural Compound That Could Protect the Brain from Too Much Salt

Quote: Eating too much salt may do more than raise blood pressure. It could also harm memory and social behavior. In a new study, Japanese researchers discovered that a soy-derived compound called LPC70 helped protect mice from several damaging effects of a high-salt diet. Mice given the supplement had lower blood pressure, better memory, and improved social interactions compared with mice consuming excess salt alone.
Article: https://www.sciencedaily.com//releases/2026/10/261017230032.htm
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    PRIME    AGING    BRAIN    BRAINWAVE    PSYCHOLOGY   

Sd421-025

Scientists Uncover 3 Key Brain Pathways Linked to Lasting Depression Relief

Quote: The researchers found that lasting improvements were consistently associated with electrical stimulation reaching three specific white matter pathways: the cingulum bundle, forceps minor, and medial uncinate fasciculus/ventral amygdalofugal pathways. These findings strengthen the case for using detailed maps of the brains connections to determine exactly where electrodes should be implanted, rather than choosing their positions based primarily on anatomical landmarks.
Article: https://www.sciencedaily.com//releases/2026/10/261017230021.htm
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    PRIME    AGING    BRAIN   

Sd421-027

Scientists Find a Youth Protein That Helps Aging Brain Cells Act Young Again

Quote: In a study published in Nature Communications, researchers found that removing TIMP2 caused brain immune cells, known as microglia, to develop characteristics linked to aging and neurodegenerative disease. When the scientists restored TIMP2 in the bloodstream of older mice, these cells became better at removing cellular debris and showed fewer molecular signs of inflammation and other potentially harmful changes.
Article: https://www.sciencedaily.com//releases/2026/10/261016070646.htm
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See Also:
  • https://www.nature.com/articles/s41467-026-74906-z
  •   Javilk's Research Links Newsletter for Week 42
    Updated 10/24/2026-02:39:34 AM
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