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    DIABETES    DRUGS    OBESITY   

Mdb42-002

Linafexor, a Pulsatile FXR Agonist, Augments Low-Dose Semaglutide for Weight Loss in Adults with Obesity, MASH, and Type 2 Diabetes

Quote: Thus, in a population with blunted GLP-1 responses, adding linafexor to low-dose semaglutide enhanced weight loss and improved body composition and hepatic measures while preserving tolerability--a dose-sparing, mechanism-complementary strategy (ClinicalTrials.gov number, NCT06492330).
Abstract: https://www.medrxiv.org/content/10.64898/2026.10.18.26365821v1
Full Text: https://www.medrxiv.org/content/10.64898/2026.10.18.26365821v1.full-text
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Search Authors: Yifei Zhang Yufei Chen Shan Huang Lei Jiang Yufan Wang Jing Ma Rong Deng Juan Du Lili Xia Yuhang Ma Peihong Wu Weituo Zhang Cong Liu Guanguan Zhao Gaihong Wang Mengyi Qian Huimin Lin Fuhua Yan Guang Ning H. Eric Xu Weiqing Wang, 
    PRIME    AGING    DIABETES    SLEEP   

Sd421-029

Scientists Discover How Deep Sleep Builds Muscle, Burns Fat, and Boosts the Brain

Quote: The discovery reveals that the relationship works in both directions. Sleep stimulates growth hormone production, but growth hormone also sends signals back to the brain that influence when we wake up. The findings could eventually help scientists develop new approaches to treating sleep disorders associated with metabolic diseases such as diabetes, as well as neurological conditions including Parkinsons and Alzheimers.
Article: https://www.sciencedaily.com//releases/2026/10/261016081140.htm
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    DIABETES   

Sd421-037

Scientists Link a Strange Sugar in Red Meat to a 63 Higher Diabetes Risk

Quote: A sugar naturally present in red meat may help explain why eating these foods has been associated with a higher risk of type 2 diabetes. Preliminary findings from a large observational study suggest that people who consume the most of this sugar face a substantially greater risk of developing the disease, potentially because of its effects on the immune system and chronic inflammation. The sugar, known as N-glycolylneuraminic acid (Neu5Gc), is particularly common in beef and lamb. Researchers found that participants with the highest intake of meat-derived Neu5Gc had a 63 higher risk of developing type 2 diabetes (T2D) compared with those who consumed the least.
Article: https://www.sciencedaily.com//releases/2026/10/261017230031.htm
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  Javilk's Research Links Newsletter for Week 42
Updated 10/24/2026-02:39:34 AM
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