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Bpt42-015

Development of CYP8B1-specific inhibitors for metabolic diseases

Quote: These findings reveal that pharmacologically inhibiting CYP8B1 is able to reshape the BA and gut microbiota profiles and effectively ameliorates metabolic diseases. Overall, CYP8B1-specific inhibitors represent a first-in-class promising, safe and effective therapeutic strategy against metabolic disorders.
Comment: Low Cytochrome P450, a family of detox enzymes, is known as Porphyria, and leavea a person with a very low tolerance to alcohol, many solvents, and other chemicals as well as sun sensitivity in many people. It is a leading cause of MCS, Multiple Chemical Sensitivities, now also called TILT, Toxic Induced Loss of Tolerance. Chemotherapy is known to cause MCS in many survivors. Antibuse and some medications also cause low Cytochrome P450. Caution is advised.
Article: https://www.biorxiv.org/content/10.64898/2026.10.20.760253v1
Search Similar: Brave Mojeek Startpage Dogpile Bing Googl Lycos Utub Yaho 
Search Authors: Zhipeng Fang Alon Roy L. Agua Jennifer Jossart Nisha Sharma Xintian Lyu Zhe Wang Shili Zhang Ji Sun Linsen Shi Juan Ayard Maggie Chang Jiahui Liu Kevin Kou John Shively Adolfo Garcia-Ocana David Horne Holly Yin Lihua Jin J. Jefferson P. Perry Wendong Huang, 

  Javilk's Research Links Newsletter for Week 42
Updated 10/24/2026-02:39:34 AM
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