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    BRAIN    CANCER    IMMUNE   

Bcb43-008

Aquaporin-4 Regulates Edema, Sustains Astrocyte Differentiation, and Constrains Immunosuppressive Remodeling in Glioblastoma

Quote: Treatment with anti-VEGFA antibody, an established anti-edema therapy, increased expression of Aqp4 and reduced vessel leakage, underscoring the role of AQP4 in the therapeutic modulation of brain water balance. Overall, this study highlights the important role of AQP4 in resolving edema and its critical function in maintaining astrocyte identity and shaping the immune landscape of GBM.
Article: https://www.biorxiv.org/content/10.64898/2026.10.23.761345v1
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Search Authors: Tanvi Joshi Kaisha Garvin Matthew J Flick Montserrat Puigdelloses Vallcorba Mehek Dedhia Zhihong Chen Raina Roche Emir Radkevich Susana Isabel Ramos Nadejda M Tsankova Nhan L Tran Leland S Hu Katherine B Peters Alex J Smith Dieter Henrik Heiland Dolores Hambardzumyan, 
    BRAIN    IMMUNE   

Bge43-008

Host brain infection induces RNAi epimutation in Mucor circinelloides and enhances blood-brain barrier invasion

Quote: This model revealed that bepA mutation enhances fungal migration across brain endothelial monolayers without detectable changes in electrical barrier resistance. These findings identify brain-induced RNAi epimutation as a mechanism of organ-specific fungal adaptation and reveal reversible silencing of a MAPK-like kinase as a route to enhanced central nervous system invasion.
Article: https://www.biorxiv.org/content/10.64898/2026.10.23.761329v1
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Search Authors: Mara Isabel Navarro-Mendoza Carlos Prez-Arques Yeseul Choi Emma Cao Zanetta Chang Ziyan Xu Yong-Sun Bahn E. Ashley Moseman Joseph Heitman, 
    BRAIN    GENETICS   

Bge43-020

Glial cells gate small RNA transport from germline to brain during transgenerational epigenetic inheritance of behavior

Quote: ID-1 mediates uptake of germline-derived RNA, followed by transcytosis to a neighboring sensory neuron, where the P11 target gene maco-1 is silenced. This glial "filter", which uses highly conserved molecular components to transcytose RNAs to neurons, reveals a general mechanism for gating small RNA access to the nervous system, paralleling the mammalian blood-brain barrier.
Article: https://www.biorxiv.org/content/10.64898/2026.10.24.761599v1
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Search Authors: Abigail K. Brown Xinbei Li Rachel Kaletsky Renee Seto Katherine E Novak Liyang Sun Coleen T. Murphy, 
    PRIME    AGING    BRAIN   

Sd432-002

Scientists Discover a Surprising Clue to Why Some Brains Resist Alzheimers

Quote: ome people have the brain changes associated with Alzheimers disease but never develop dementia. While others experience worsening memory and thinking problems, these individuals remain mentally sharp despite signs of the disease in their brains. Scientists have long struggled to explain why. Now, researchers at the Netherlands Institute for Neuroscience have uncovered a promising clue. Their findings suggest that a rare group of brain cells, known as immature neurons, may behave differently in people who resist Alzheimers symptoms. Rather than simply replacing damaged cells, these neurons could help protect the brain from the harmful effects of the disease.
Article: https://www.sciencedaily.com//releases/2026/10/261025222538.htm
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    BRAIN    TECH   

Sd432-011

Tiny Magnetic Vortices Could Help Computers Work More Like Your Brain

Article: https://www.sciencedaily.com//releases/2026/10/261025073038.htm
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    BRAIN    HEART   

Sd432-015

Could Lowering High Blood Pressure Be as Simple as Stimulating Your Ear?

Quote: A small device that delivers gentle electrical pulses through the ear could offer a new approach to treating stubborn high blood pressure. In a clinical trial led by researchers at Queen Mary University of London, the technology proved safe, well tolerated, and practical for patients to use at home. Although the treatment did not significantly lower blood pressure compared with a placebo device across all participants, researchers observed encouraging results in patients with more severe hypertension. The findings suggest that stimulating nerves in the ear could eventually help certain people whose blood pressure remains elevated despite taking medication.
Article: https://www.sciencedaily.com//releases/2026/10/261023023732.htm
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    PRIME    BRAIN    HEART   

Sd432-016

Scientists Discover a Hidden Switch That Burns Fat and Blocks New Fat Cells

Quote: A small device that delivers gentle electrical pulses through the ear could offer a new approach to treating stubborn high blood pressure. In a clinical trial led by researchers at Queen Mary University of London, the technology proved safe, well tolerated, and practical for patients to use at home. Although the treatment did not significantly lower blood pressure compared with a placebo device across all participants, researchers observed encouraging results in patients with more severe hypertension. The findings suggest that stimulating nerves in the ear could eventually help certain people whose blood pressure remains elevated despite taking medication.
Article: https://www.sciencedaily.com//releases/2026/10/261023002905.htm
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    PRIME    BRAIN    HEART    NUTRITION   

Sd432-042

Mediterranean Diet May Boost Tiny Proteins That Protect the Heart and Brain

Quote: Scientists have uncovered a surprising new clue to why the Mediterranean diet is so good for the heart, brain, and healthy aging. Researchers at USC found that older adults who closely followed the diet had higher levels of two tiny proteins, humanin and SHMOOSE, produced by the mitochondria, the energy-producing structures inside cells.
Article: https://www.sciencedaily.com//releases/2026/10/261023003337.htm
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  Javilk's Research Links Newsletter for Week 43
Updated 10/31/2026-02:16:20 AM
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