Research
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Scanned: 3392
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    PRIME    PRIO    IMMUNE    NUTRITION   

Aee44-1053

Are Multivitamin Supplements a Waste of Money?

Quote: In this 2025 study researchers reported: "Regular MVM (multivitamin–multimineral) supplementation among older Taiwanese adults without prior MVM use could meaningfully reduce dementia burden and generate substantial healthcare and societal cost savings. These findings highlight regular MVM use as a pragmatic strategy to support cognitive health in aging populations...Regular MVM use was projected to prevent 204,250 dementia cases and 23,649 premature deaths.
Comment: Vitamins certainly helped me, kept me looking younger than people my age. The real question is how much do you really need? The Minimum Daily Adult Requirment is an absolute minimum for a healthy person. Illness often ramps up the need for specific vitamins, especially vitamin C.
Article: https://richardgoldberg.substack.com/p/are-multivitamin-supplements-a-waste
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    CANCER    IMMUNE   

Bcb44-002

AMD1-driven MTA production sustains chemoresistance by rewiring PMN-MDSC immunosuppression

Quote: Our findings identify MTA as an important metabolic link between chemoresistant tumor cells and PMN-MDSCs to sustain immunosuppression and therapeutic resistance. Targeting AMD1-dependent MTA production represents a valuable strategy for overcoming chemo-immunotherapy resistance.
Article: https://www.biorxiv.org/content/10.64898/2026.11.02.763561v1
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Search Authors: Yinan Wang Wen Qiao Bin Yu Cegui Hu Hao Li Hanjun Li Rongyu Zhang Luying Li Peng Li Nannan Sha Shijia Bao Shanni Guo Guiying Wei Dongxi Xiang Jun Gui, 
    IMMUNE   

Bim44-002

The IFN--inducible GTPase IIGP1 regulates mitochondrial remodeling and immunometabolic reprogramming during inflammatory macrophage polarization

Article: https://www.biorxiv.org/content/10.64898/2026.11.02.763539v1
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Search Authors: Anup Kumar Singh Samriddhi Sharma Kriti Ahuja Rajender K Motiani Srikanth Repole Manas Kumar Santra Arvind Sahu, 
    PRIME    IMMUNE   

Bim44-011

Decoding antibody-antigen recognition: the BL8 language and its application in calibrating deep learning predictions

Quote: Using 15,396 experimental interface records from the Structural Antibody Database (SAbDab), we built a fixed reference atlas containing 1,498 discrete BL8 signatures. The atlas shows that natural interfaces occupy a diverse, long-tailed structural space in which similar geometric scaffolds can be associated with different chemical and sequence features. Furthermore, we projected 28,501 predicted complexes involving programmed death-ligand 1 (PD-L1), the SARS-CoV-2 receptor-binding domain (RBD), and programmed cell death protein 1 (PD-1), generated using AlphaFold 3 (AF3), Protenix-v2, and OpenDDE, into the reference space.
Article: https://www.biorxiv.org/content/10.64898/2026.10.30.763264v1
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Search Authors: Tingwei Miao Ruohan Zhu Ruiqi Lin Juncheng Qian Yi Feng Shuang Chen Yuxin Wang Daoyou Chen Yanling Wu Tianlei Ying, 
    GENETICS    IMMUNE    METABOLISM   

Bmo44-007

A new tool for quantifying mitochondrial RNA processing intermediates reveals increased levels of immature mRNA species under oxidative stress

Article: https://www.biorxiv.org/content/10.64898/2026.10.30.763231v1
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Search Authors: Ulas Ozkurede Shreya Rajhans Federica Accornero Julia C Liu, 
    IMMUNE   

Sd444-007

Scientists Solve 30-year-old Mystery and Discover a Hidden Defense Against Inflammation

Quote: The Immune Systems Hidden Protective Shield Further experiments revealed how this protection works. When immune cells attack dangerous microorganisms, they release highly reactive substances that can harm nearby healthy cells. The 5-oxoETE pathway helps tissues withstand this chemical stress, reducing the risk that the bodys own defenses will cause unnecessary injury.
Article: https://www.sciencedaily.com//releases/2026/11/261101010554.htm https://www.sciencedaily.com//releases/2026/11/261101010554.htm/releases/2026/11/261101010554.htm
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  Javilk's Research Links Newsletter for Week 44
Updated 11/06/2026-10:26:45 PM
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