AGING GENETICS IMMUNE
Mge45-002	Single-Cell Transcriptome-Wide Mendelian Randomization and Colocalization Analysis Reveals Immune Cell-Specific Mechanisms in Alzheimers Disease
	Article:	https://www.medrxiv.org/content/10.64898/2026.11.03.26367234v1
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	Search Authors:	Youwei Si Youwen Si,
AGING PHYSICAL
Mgr44-008	Physical Frailty Accelerates Multimorbidity Accumulation Across Distinct Disease Patterns
	Article:	https://www.medrxiv.org/content/10.64898/2026.10.15.26365629v1
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	Search Authors:	Yaqi Huang Zixin Hu Meng Hao Xiangnan Li Yulong Tang Shuai Jiang Xiaofeng Wang Li Han Jiucun Wang Yi Li Hui Zhang,
PRIME AGING METABOLISM NUTRITION PHYSICAL
Mgr44-010	Plasma metabolomic profiling of frailty in older adults at risk of dementia
	Quote:	Conclusions Frailty index was associated with carboxylic acids and derivatives, fatty acyls and organooxygen compounds across multiple clusters, and a large number of lipids were linked to frailty score, potentially implicating dysregulation of energy metabolism in the pathophysiology of frailty and forming a panel of predictive biomarkers of at risk patients.
	Article:	https://www.medrxiv.org/content/10.64898/2026.10.06.26364906v1
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	Search Authors:	Isabelle Alldritt Johannes C. Michaelian Rachael Yu Sarah E. Deemer Richard J. Mills Sharon L. Naismith Andrew Philp,
AGING
Mgr45-002	A digital programme to prevent falls and improve wellbeing in people living with dementia in the community: Quantitative results from the KOKU-LITE feasibility study
	Quote:	Background Falls are common and costly among people living with Dementia (PLwD). Keep on Keep up (KOKU) is a UK National Health Service (NHS) approved tablet-based, digital gamified programme with strength and balance exercises and health literacy games, designed with and for older people at risk of falls.
	Article:	https://www.medrxiv.org/content/10.64898/2026.10.27.26366422v1
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	Search Authors:	Jaheeda Gangannagaripalli Saima Ahmed Amelia Parchment Chunhu Shi Schenelle Dayna Dlima Rachel Christie Chris Todd Emma Vardy Emma Stanmore,
PRIME AGING BRAIN BRAINWAVE PSYCHOLOGY
Mor45-003	Reactivating Residual Motor Circuits in Complete Spinal Cord Injury Through Mode- and Site-Specific Transcranial Magnetic Stimulation: A Pilot Randomized Controlled Trial
	Quote:	Transcranial magnetic stimulation (rTMS) and intermittent theta burst stimulation (iTBS) induces LTP-like plasticity, however their comparative efficacy in cSCI remains unclear.... Quality of life improved significantly (p 0.05) in both rTMS and iTBS groups.
	Article:	https://www.medrxiv.org/content/10.64898/2026.10.31.26366692v1
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	Search Authors:	Deeksha Patel Rohit Banerjee Suman Jain Kamran Farooque Asjad Mahmood Hanuman P Sharma Deepak Gupta Nand Kumar,
AGING NUTRITION
Mph44-007	Part 1 of a 2-part, open-label clinical trial evaluating repeated nicotinamide riboside parenteral administration: 3 consecutive days of intramuscular and subcutaneous injections
	Article:	https://www.medrxiv.org/content/10.64898/2026.10.12.26365345v1
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	Search Authors:	Yasmeen Nkrumah-Elie Jun Kwon Anne Russ Sierra Simpson Frehiwet Hailu Tracy Allen Halland Chen Andrew Shao,
AGING BRAIN GENETICS
Sd451-004	Alzheimers May Have Early Warning Signs Outside the Brain
	Quote:	Scientists at the University of Central Florida (UCF) have discovered that genetic mutations associated with Alzheimers can interfere with the nerves that control muscle movement, even without involvement from the brain or spinal cord. The findings could help explain why some people with Alzheimers experience changes in walking, balance, or coordination long before noticeable memory problems emerge. The discovery raises the possibility that movement difficulties could provide earlier warning signs of the disease and that treatments focused exclusively on the brain may overlook important problems elsewhere in the body.
	Article:	https://www.sciencedaily.com//releases/2026/11/261108233103.htm
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	See Also:	https://www.ucf.edu/news/ucf-study-suggests-some-alzheimers-symptoms-may-begin-outside-the-brain/
AGING DRUGS
Sd451-037	Common Osteoporosis Drugs Linked to 24 Lower Dementia Risk in Major Study
	Quote:	A common class of drugs used to treat osteoporosis may have an unexpected benefit: lowering the risk of Alzheimers disease and other forms of dementia. In a study involving more than 120,000 older adults, researchers at the University of Hong Kong (HKUMed) found that patients taking certain medications to strengthen their bones were significantly less likely to develop dementia. The medications, known as nitrogen-containing bisphosphonates (NBPs), are widely prescribed to prevent bone loss and fractures.
	Article:	https://www.sciencedaily.com//releases/2026/11/261108233037.htm
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PRIME AGING DIABETES METABOLISM NUTRITION
Sd451-038	A Little-Known Protein Could Be a Major Culprit in Type 2 Diabetes
	Quote:	The protein, known as Miro1, was found at higher levels in the skeletal muscles of people with Type 2 diabetes. In preclinical experiments, scientists discovered that removing Miro1 restored the muscles response to insulin. They also found that exercise lowered Miro1 levels in people with the disease, offering new insight into how physical activity improves insulin sensitivity.
	Article:	https://www.sciencedaily.com//releases/2026/11/261106174543.htm
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Javilk's Research Links Newsletter for Week 45
Updated 11/14/2026-03:15:39 AM
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Mge45-002

Single-Cell Transcriptome-Wide Mendelian Randomization and Colocalization Analysis Reveals Immune Cell-Specific Mechanisms in Alzheimers Disease

Mgr44-008

Physical Frailty Accelerates Multimorbidity Accumulation Across Distinct Disease Patterns

Mgr44-010

Plasma metabolomic profiling of frailty in older adults at risk of dementia

Mgr45-002

A digital programme to prevent falls and improve wellbeing in people living with dementia in the community: Quantitative results from the KOKU-LITE feasibility study

Mor45-003

Reactivating Residual Motor Circuits in Complete Spinal Cord Injury Through Mode- and Site-Specific Transcranial Magnetic Stimulation: A Pilot Randomized Controlled Trial

Mph44-007

Part 1 of a 2-part, open-label clinical trial evaluating repeated nicotinamide riboside parenteral administration: 3 consecutive days of intramuscular and subcutaneous injections

Sd451-004

Alzheimers May Have Early Warning Signs Outside the Brain

Sd451-037

Common Osteoporosis Drugs Linked to 24 Lower Dementia Risk in Major Study

Sd451-038

A Little-Known Protein Could Be a Major Culprit in Type 2 Diabetes