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    GUT    PSYCHOLOGY   

Mga44-002

Understanding Psychological Health in Adults with Irritable Bowel Syndrome: A Cross-Sectional Study Using the All of Us Research Program

Quote: Conclusions Psychological health among adults with irritable bowel syndrome was associated with interconnected individual and social factors within an adapted Stress Process Model. Childhood adversity and adult attention-deficit/hyperactivity disorder-related symptoms showed direct and indirect associations with psychological health, with loneliness emerging as the most consistent social factor. These findings support prospective investigation of individual vulnerabilities and social experiences in psychological health. The cross-sectional design does not establish temporal ordering or causal mediation.
Article: https://www.medrxiv.org/content/10.64898/2026.10.20.26365988v1
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Search Authors: Weizi Wu Aolan Li Jie Chen Eunhea You Peiyuan Liu Leonel Rodriguez Ming-Hui Chen Xiaomei Cong, 
    CANCER    GUT   

Mga44-004

Protracted copy number alteration evolution in Barretts oesophagus leading to oesophageal cancer

Quote: Detection of copy number alterations (CNAs) in Barretts oesophagus (BO) predicts oesophageal adenocarcinoma (OAC) risk.
Article: https://www.medrxiv.org/content/10.64898/2026.10.16.26365037v1
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Search Authors: Calum Gabbutt Angel Fernndez-Sanromn Heather Grant Salvatore Milite William CH Cross Nicholas A Wright Carlo C Maley Andrea Sottoriva Giulio Caravagna Thomas G Paulson Trevor A Graham, 
    GUT   

Mga44-006

Sedatives reduce human gastric slow-wave amplitude, assessed by a multicenter study of endoscopic gastric mapping

Quote: Conclusions Inferences Higher procedural sedative doses are associated with lower-amplitude gastric slow-waves. Procedural sedation dose and opiate administration should be carefully considered when interpreting GI electrophysiology measurements.
Article: https://www.medrxiv.org/content/10.64898/2026.10.15.26365429v1
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Search Authors: Peter Tremain Jarrah M. Dowrick Chih-Hsiang Alexander Chan David Rowbotham Gary Lim Gregory OGrady Leo K. Cheng James Mckeage Timothy R. Angeli-Gordon, 
    AI-CHAT    PRIME    GUT    MICROBIOME   

Mga44-008

Serum proteins predict incident inflammatory bowel disease 14 years before diagnosis: a machine-learning and Cox modelling in the UK Biobank

Quote: All proteomics models outperformed clinical models. Smoking remained the only significant clinical predictor in the combined proteomics clinical model. 48 unique proteins were identified across the three models, with 16 reaching statistical significance (p 0.05). Machine learning-based feature selection with statistical survival modelling identifies plasma proteins that predict incident IBD and highlight biologically plausible, potentially targetable pathways in the preclinical phase of IBD.
Article: https://www.medrxiv.org/content/10.64898/2026.10.13.26365425v1
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Search Authors: Tobias Erich Niebuhr Joshua Fieggen Bradley Max Segal Anuj Patel David Clifton Lei Clifton, 
    GUT    MICROBIOME   

Mga44-009

Disrupted microbial queuosine biosynthesis contributes to dysbiosis in human inflammatory bowel disease

Quote: Conclusions Our study used multi-omics datasets to define a novel functional dysbiosis characterized by a reduction of microbial Q-biosynthesis in patients with IBD. Vitamin q and its tRNA modification is lesser-recognized in human IBD. Understanding the cellular and organismal mechanisms of this microbiome-dependent micronutrient will advance the prevention of IBD and improve the quality of life of patients with IBD.
Article: https://www.medrxiv.org/content/10.64898/2026.10.12.26365231v1
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Search Authors: Yueqing An Yinglin Xia Jun Sun, 
    PRIME    CANCER    GUT    MICROBIOME    NUTRITION   

Mga44-010

Replacing animal-sourced with plant-sourced proteins alters gut microbiota and biomarkers associated with colorectal cancer risk in healthy adults: A randomized feeding study

Quote: The 70 plant-protein diet also reduced fecal secondary and taurine-conjugated BAs, including the CRC-associated BAs DCA and LCA. Plasma glucuronidated BAs increased, expanding the circulating pool of readily excreted BA conjugates. Higher insoluble fiber intake was associated with greater microbiota restructuring and lower fecal NOCs. Methanogen carriers had higher baseline fecal NOCs and features of slower colonic transit, and showed weaker microbiota and less favorable BA responses to the 70 plant-protein diet. Baseline methanogen carriage thus could be exploited for participant stratification in future dietary interventions. ClinicalTrials.gov: NCT03206827.
Article: https://www.medrxiv.org/content/10.64898/2026.10.13.26365402v1
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Search Authors: Ching Jian Tiina Pellinen Antti Karkman Mikko Neuvonen Mikko Niemi Anne Salonen Anne-Maria Pajari, 

  Javilk's Research Links Newsletter for Week 45
Updated 11/14/2026-03:15:39 AM
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