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    PRIME    DENTAL    METABOLISM    MICROBIOME   

Mde44-011

Multi-omic Characterization of the Oral Ecosystem and Assessment of Dental Health and Dental Hygiene Metadata in the Participants from a Large Randomized Double-Blinded Clinical Study

Quote: This comprehensive approach allowed for the identification of specific links between microbial and metabolic signatures and overall wellness, providing a contemporary baseline to enable the development of personalized prevention and treatment strategies to help safeguard oral and systemic public health.
Article: https://www.medrxiv.org/content/10.64898/2026.09.24.26363963v1
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Search Authors: Hannah Moglowsky Sofronia M. Ringold Rodney Jones Natalie Wall Alexander Gudjonsson Thorsten Gravert Janne Marie Moll Anne ODonnell Katie Lee Emily A. Stein, 
    AI-CHAT    PRIME    GUT    MICROBIOME   

Mga44-008

Serum proteins predict incident inflammatory bowel disease 14 years before diagnosis: a machine-learning and Cox modelling in the UK Biobank

Quote: All proteomics models outperformed clinical models. Smoking remained the only significant clinical predictor in the combined proteomics clinical model. 48 unique proteins were identified across the three models, with 16 reaching statistical significance (p 0.05). Machine learning-based feature selection with statistical survival modelling identifies plasma proteins that predict incident IBD and highlight biologically plausible, potentially targetable pathways in the preclinical phase of IBD.
Article: https://www.medrxiv.org/content/10.64898/2026.10.13.26365425v1
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Search Authors: Tobias Erich Niebuhr Joshua Fieggen Bradley Max Segal Anuj Patel David Clifton Lei Clifton, 
    GUT    MICROBIOME   

Mga44-009

Disrupted microbial queuosine biosynthesis contributes to dysbiosis in human inflammatory bowel disease

Quote: Conclusions Our study used multi-omics datasets to define a novel functional dysbiosis characterized by a reduction of microbial Q-biosynthesis in patients with IBD. Vitamin q and its tRNA modification is lesser-recognized in human IBD. Understanding the cellular and organismal mechanisms of this microbiome-dependent micronutrient will advance the prevention of IBD and improve the quality of life of patients with IBD.
Article: https://www.medrxiv.org/content/10.64898/2026.10.12.26365231v1
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Search Authors: Yueqing An Yinglin Xia Jun Sun, 
    PRIME    CANCER    GUT    MICROBIOME    NUTRITION   

Mga44-010

Replacing animal-sourced with plant-sourced proteins alters gut microbiota and biomarkers associated with colorectal cancer risk in healthy adults: A randomized feeding study

Quote: The 70 plant-protein diet also reduced fecal secondary and taurine-conjugated BAs, including the CRC-associated BAs DCA and LCA. Plasma glucuronidated BAs increased, expanding the circulating pool of readily excreted BA conjugates. Higher insoluble fiber intake was associated with greater microbiota restructuring and lower fecal NOCs. Methanogen carriers had higher baseline fecal NOCs and features of slower colonic transit, and showed weaker microbiota and less favorable BA responses to the 70 plant-protein diet. Baseline methanogen carriage thus could be exploited for participant stratification in future dietary interventions. ClinicalTrials.gov: NCT03206827.
Article: https://www.medrxiv.org/content/10.64898/2026.10.13.26365402v1
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Search Authors: Ching Jian Tiina Pellinen Antti Karkman Mikko Neuvonen Mikko Niemi Anne Salonen Anne-Maria Pajari, 

  Javilk's Research Links Newsletter for Week 45
Updated 11/14/2026-03:15:39 AM
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