PAIN
Mep44-009	Spinal Manipulation and Other Conservative Treatments for Acute and Chronic Low Back Pain Compared with Natural History and Sham: A Bayesian Network Meta-Analysis
	Quote:	Conclusions Whether an LBP treatment looks effective depends on its comparator. Our linked design keeps the prognosis evidence and the treatment evidence apart until the final comparison. In acute LBP, recovery rates were high, and no treatment added a detectable benefit beyond sham or beyond expected natural recovery. In chronic LBP, SMT and exercise showed some benefit beyond natural history and sham. Even so, only about one in three chronic patients was modeled to recover with either treatment.
	Article:	https://www.medrxiv.org/content/10.64898/2026.09.16.26359287v2
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	Search Authors:	James Michael Menke Aurelio Jos Figueredo Mateo Peaherrera-Aguirre,
PRIME PAIN TECH
Mor44-009	Smartwatch-derived digital biomarkers distinguish episodic pain phenotypes in chronic low back pain
	Quote:	However, when we examined how these signals changed and fluctuated over time, we were able to distinguish episodic from non-episodic pain patients with meaningful accuracy. Notably, combining heart rate and activity data performed better than either alone. This work suggests that the smartwatch many people already wear on their wrist could one day help clinicians objectively monitor chronic pain in real time, reducing the burden of self-reporting and potentially enabling earlier detection of pain flare-ups.
	Article:	https://www.medrxiv.org/content/10.64898/2026.09.02.26362006v1
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	Search Authors:	Karim Khattab Aniket Pratapneni Gregorij Kurillo Trisha Hue Patricia Zheng Jeffrey Lotz Abel Torres-Espin Jeannie F Bailey span classnlm-collab data-hwp-idcollab-1The REACH Investigators,
PRIME BRAINWAVE MUSIC PAIN PSYCHOLOGY
Mpa44-005	Daily personalized music listening versus audiobook listening for chronic non-cancer pain in patients on long-term opioid therapy: a randomized controlled trial
	Quote:	A #8805;30 pain-reduction criterion was met by 21.4 of participants in the music group and none in the audiobook group (p0.023). An exploratory between-group difference in pain intensity favoring music was also observed at follow-up. Other analgesic and secondary outcomes showed no significant between-group differences, although exploratory within-group improvements in mood and health-related quality of life were observed with music.
	Article:	https://www.medrxiv.org/content/10.64898/2026.10.13.26365452v1
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	Search Authors:	Jssica Garrido-Pedrosa Mara Fernanda Porto Ancor Serrano-Afonso Roco Valenzuela Lorena Zapata Mara Florencia Vidal Paloma Luna-Daz Emma Segura Xim Cerda-Company Sebasti Videla Antoni Rodrguez-Fornells Jennifer Grau-Snchez Vctor Fernndez-Dueas,
PAIN
Mpa44-007	Impact of self-reported interoceptive abilities on postoperative pain
	Quote:	Perspective This study identified associations between self-reported interoceptive abilities and acute postsurgical pain in two independent cohorts. These findings could contribute to the understanding of individual differences in pain perception, and provide an initial foundation for exploring the effectiveness of interoceptive therapies in preventing severe postoperative pain.
	Article:	https://www.medrxiv.org/content/10.64898/2026.10.08.26365039v1
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	Search Authors:	Barbara P. Weldam Larissa L. Meijer Oscar F.C. van den Bosch Marjelle E.C. van Driel Leon Timmerman Jacqueline F.M. van Dijk Madelijn Strick span classnlm-collab data-hwp-idcollab-1IPOP research group Mienke Rijsdijk,
COVID-19 PAIN
Mpa44-008	Persistent Fibromyalgia-like symptom presentation in Long COVID-associated chronic musculoskeletal pain: a longitudinal cohort study
	Quote:	Conclusions FMS-like symptoms remain highly prevalent several years after acute COVID-19 and persist over a further 12 months, suggesting that LC-CMP frequently represents a persistent long-term condition with substantial overlap with FMS. These findings support closer integration of LC and chronic pain rehabilitation services and add to the wider literature linking post-infectious processes with FMS-like symptoms.
	Article:	https://www.medrxiv.org/content/10.64898/2026.10.07.26364942v1
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	Search Authors:	Brbara Silva-Passadouro Ioannis Delis Alexander J. Casson Christopher Brown Sarah L. Astill Manoj Sivan,
DENTAL PAIN
Mre44-010	Efficacy of physiotherapy in reducing pain in subjects with temporomandibular disorders: a systematic review with network meta-analysis
	Quote:	Results 25 randomised clinical trials for a total of 1,540 people were included. The main comparisons were: manual therapy and/or therapeutic exercise vs no treatment or placebo, occlusal splint, and instrumental physiotherapy. In most studies, manual therapy and therapeutic exercise were more effective than controls in reducing pain. However, the network meta-analysis indicated that multimodal treatments were the most effective. The methodological quality of the included studies ranged from 3 to 9 points.
	Article:	https://www.medrxiv.org/content/10.64898/2026.10.11.26365246v1
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	Search Authors:	Alessandro Alvisi Alberto Casalini Laura Mammana Alessandro Ugolini,
PRIME PAIN PHYSICAL
Msm45-014	Real-World Use, Dosing, and Reported Side Effects of BPC-157 and TB-500 for Musculoskeletal Injury: An Analysis of Online Communities
	Quote:	Objective To describe how people use the unapproved peptides BPC-157 and TB-500 for tendon, ligament and muscle injury and what side effects they report.... The median BPC-157 dose was about 2.7 times the human-equivalent dose of the rat regimen, and 27.2 of users reported a side effect. Anhedonia was about eight times as common as among users of four other peptides in the same communities.
	Article:	https://www.medrxiv.org/content/10.64898/2026.11.04.26367022v1
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	Search Authors:	Joshua Cassinat Claire Callan Catherine Liggett Vonda Wright,

Javilk's Research Links Newsletter for Week 45
Updated 11/14/2026-03:15:39 AM
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Mep44-009

Spinal Manipulation and Other Conservative Treatments for Acute and Chronic Low Back Pain Compared with Natural History and Sham: A Bayesian Network Meta-Analysis

Mor44-009

Smartwatch-derived digital biomarkers distinguish episodic pain phenotypes in chronic low back pain

Mpa44-005

Daily personalized music listening versus audiobook listening for chronic non-cancer pain in patients on long-term opioid therapy: a randomized controlled trial

Mpa44-007

Impact of self-reported interoceptive abilities on postoperative pain

Mpa44-008

Persistent Fibromyalgia-like symptom presentation in Long COVID-associated chronic musculoskeletal pain: a longitudinal cohort study

Mre44-010

Efficacy of physiotherapy in reducing pain in subjects with temporomandibular disorders: a systematic review with network meta-analysis

Msm45-014

Real-World Use, Dosing, and Reported Side Effects of BPC-157 and TB-500 for Musculoskeletal Injury: An Analysis of Online Communities