AGING PHYSICAL
Mgr44-008	Physical Frailty Accelerates Multimorbidity Accumulation Across Distinct Disease Patterns
	Article:	https://www.medrxiv.org/content/10.64898/2026.10.15.26365629v1
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	Search Authors:	Yaqi Huang Zixin Hu Meng Hao Xiangnan Li Yulong Tang Shuai Jiang Xiaofeng Wang Li Han Jiucun Wang Yi Li Hui Zhang,
PRIME AGING METABOLISM NUTRITION PHYSICAL
Mgr44-010	Plasma metabolomic profiling of frailty in older adults at risk of dementia
	Quote:	Conclusions Frailty index was associated with carboxylic acids and derivatives, fatty acyls and organooxygen compounds across multiple clusters, and a large number of lipids were linked to frailty score, potentially implicating dysregulation of energy metabolism in the pathophysiology of frailty and forming a panel of predictive biomarkers of at risk patients.
	Article:	https://www.medrxiv.org/content/10.64898/2026.10.06.26364906v1
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	Search Authors:	Isabelle Alldritt Johannes C. Michaelian Rachael Yu Sarah E. Deemer Richard J. Mills Sharon L. Naismith Andrew Philp,
BODY PHYSICAL
Mor44-002	Effectiveness of dual-mobility cups for preventing dislocation after primary total hip arthroplasty by a posterolateral approach compared to unipolar cups in elderly patients
	Article:	https://www.medrxiv.org/content/10.64898/2026.10.27.26364841v1
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	Search Authors:	Okke Hoonhout Nienke W Willigenburg Rudolf W Poolman Esther Scheijbeler Amy Hofman Nini H Jonkman,
ARTHRITIS BODY GENETICS PHYSICAL
Mor44-005	HLA Genotype is Associated with Patient Reported Outcomes and Adverse Reactions to Metal Debris in Patients with Cobalt-Chrome Knee Arthroplasties
	Quote:	Conclusions A higher CoGR score was associated with worse patient-reported outcome and higher odds of histologically confirmed adverse reaction to metal debris at revision. Adverse immune responses may be a more significant factor in unexplained pain after KA than is generally recognised.
	Article:	https://www.medrxiv.org/content/10.64898/2026.10.12.26365276v1
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	Search Authors:	David J Langton Rohan Bhalekar Yash Borikar Stephen Wells Nick Clement David Deehan Dominie Guest Chris Harrington Simon Jameson Gillian Leitch Rachael McManus Moreica Pabbruwe Jon Phillips Andrew Porteous Steven Rushton Alasdair Santini Samantha Tross Raghavendra Sidaginamale,
PHYSICAL
Mor44-010	Autograft Selection in Anterior Cruciate Ligament Reconstruction: A Meta-Analysis of Patellar Tendon versus Hamstring Tendon Outcomes in Randomized Controlled Trials
	Article:	https://www.medrxiv.org/content/10.64898/2026.09.02.26361916v1
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	Search Authors:	Saad Akram Maarij Nadeem,
ARTHRITIS IMMUNE PHYSICAL
Mrh44-005	Combining A Massively Parallel Reporter Assay and Human Data to Elucidate Genetic Mechanisms Driving Risk for Juvenile Idiopathic Arthritis
	Quote:	Results SNPs identified on MPRA were associated with gene expression levels in a broad range of immune cells in the DICE database, including CD4 and CD8 T lymphocytes, monocytes, NK cells, and B cells. MPRA-identified SNPs showed strong associations with gene expression in GTEx whole blood, spleen, and/or EBV-transformed lymphocytes.
	Article:	https://www.medrxiv.org/content/10.64898/2026.08.24.26361225v2
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	Search Authors:	Kaiyu Jiang Susan Kales Ryan Tewhey James N. Jarvis,
PRIME PAIN PHYSICAL
Msm45-014	Real-World Use, Dosing, and Reported Side Effects of BPC-157 and TB-500 for Musculoskeletal Injury: An Analysis of Online Communities
	Quote:	Objective To describe how people use the unapproved peptides BPC-157 and TB-500 for tendon, ligament and muscle injury and what side effects they report.... The median BPC-157 dose was about 2.7 times the human-equivalent dose of the rat regimen, and 27.2 of users reported a side effect. Anhedonia was about eight times as common as among users of four other peptides in the same communities.
	Article:	https://www.medrxiv.org/content/10.64898/2026.11.04.26367022v1
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	Search Authors:	Joshua Cassinat Claire Callan Catherine Liggett Vonda Wright,

Javilk's Research Links Newsletter for Week 45
Updated 11/14/2026-03:15:39 AM
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Mgr44-008

Physical Frailty Accelerates Multimorbidity Accumulation Across Distinct Disease Patterns

Mgr44-010

Plasma metabolomic profiling of frailty in older adults at risk of dementia

Mor44-002

Effectiveness of dual-mobility cups for preventing dislocation after primary total hip arthroplasty by a posterolateral approach compared to unipolar cups in elderly patients

Mor44-005

HLA Genotype is Associated with Patient Reported Outcomes and Adverse Reactions to Metal Debris in Patients with Cobalt-Chrome Knee Arthroplasties

Mor44-010

Autograft Selection in Anterior Cruciate Ligament Reconstruction: A Meta-Analysis of Patellar Tendon versus Hamstring Tendon Outcomes in Randomized Controlled Trials

Mrh44-005

Combining A Massively Parallel Reporter Assay and Human Data to Elucidate Genetic Mechanisms Driving Risk for Juvenile Idiopathic Arthritis

Msm45-014

Real-World Use, Dosing, and Reported Side Effects of BPC-157 and TB-500 for Musculoskeletal Injury: An Analysis of Online Communities